Actively Recruiting
High-Risk Transcriptome Molecular Prediction Study of MASH-Associated Colorectal Polyps
Led by Shanghai East Hospital · Updated on 2026-03-11
100
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the molecular characteristics of colorectal polyps in patients with metabolic dysfunction-associated steatohepatitis (MASH) compared to individuals without fatty liver, and to identify potential transcriptomic biomarkers for high-risk polyps. The main questions it aims to answer are: What are the key gene expression differences in adenomatous polyps between MASH patients and non-fatty liver individuals? Can specific high-risk transcriptional molecules in plasma and polyp tissue serve as biomarkers for MASH-related colorectal polyps? Participants already scheduled for colonoscopic polypectomy as part of their routine care will provide a small portion of their polyp tissue, residual plasma from standard blood tests, and allow use of their stored pathological slides for research; they will also be followed up every six months.
CONDITIONS
Official Title
High-Risk Transcriptome Molecular Prediction Study of MASH-Associated Colorectal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD) according to 2018 guidelines
- Male or female patients aged 18 to 70 years
- Signed informed consent and understanding of the study protocol
You will not qualify if you...
- Chronic liver diseases from other causes (alcoholic, viral, autoimmune, drug-induced), decompensated cirrhosis, or primary liver cancer
- Serious diseases of other major organs (heart, kidney, lung) or bleeding disorders
- Lack of legal capacity or poor insight
AI-Screening
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Trial Site Locations
Total: 1 location
1
Shanghai East Hospital
Shanghai, Shanghai Municipality, China, 200120
Actively Recruiting
Research Team
T
Ting Mao, Bachelor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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