Immunoprofiling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder

What this Trial Is About

Researchers are studying the immune cell makeup in the blood of children with Attention Deficit/Hyperactivity Disorder (ADHD) compared to typically developing children. The study aims to identify differences in immune cell types, protein expression, and signaling pathways, as well as explore how immune function relates to brain activity patterns in children with ADHD. This observational study is supported by the First Affiliated Hospital of Zhejiang University and focuses on understanding the immune system and brain function in ADHD. Participants will provide about 5 ml of peripheral blood to analyze immune cells using advanced mass spectrometry flow cytometry. They will also undergo cognitive assessments including IQ testing, Stroop color-word test, and Trail Making Test, along with clinical interviews. Brain structure and functional MRI scans will be performed to collect detailed imaging data. Both children with ADHD and typically developing controls will participate in these evaluations. During the study, researchers will gather demographic and clinical information, perform clinical diagnosis interviews, and assess ADHD symptoms. They will measure cognitive function and brain imaging results, tracking differences between groups. The main outcomes include immune cell profiles, cognitive test results, and brain MRI data collected during participant recruitment and data collection from November to December 2023. The study will observe children aged 6 to 12 years, with follow-up and data analysis continuing through 2027.

Immunoprofilling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder