Actively Recruiting
Immunotherapy-related CRP Kinetics in Metastatic Gynecological Malignancies
Led by University Hospital Tuebingen · Updated on 2026-02-10
120
Participants Needed
1
Research Sites
602 weeks
Total Duration
On this page
Sponsors
U
University Hospital Tuebingen
Lead Sponsor
U
University Hospital Ulm
Collaborating Sponsor
AI-Summary
What this Trial Is About
ICK-Gyn is a prospective, multicentric, non-interventional investigator-initiated trial (IIT) that aims to investigate the prognostic value of CRP kinetics in advanced or metastatic gynecological malignancies under immune checkpoint inhibitor (ICI) therapy on the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS).
CONDITIONS
Official Title
Immunotherapy-related CRP Kinetics in Metastatic Gynecological Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women 18 years of age or older
- Histologically confirmed metastatic gynecological malignancies regardless of therapy line
- Eligibility for immune checkpoint inhibitor (ICI) therapy in the experimental group
- Planned ICI therapy combined with palliative chemotherapy in the experimental group
- Receiving chemotherapy without ICIs as first therapy line in the control group
- Provided written informed consent to participate in ICK-Gyn
You will not qualify if you...
- No indication for ICI therapy in the experimental group
- Prior ICI therapy before enrollment
- Advanced or metastatic endometrial or cervical cancer in second or later therapy line without ICI indication
- Pregnant or lactating women
- Poor general health condition not suitable for chemotherapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Women's Health
Tübingen, Germany, 72076
Actively Recruiting
Research Team
D
Dominik Dannehl, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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