A meta-analysis of the efficacy of laser phototherapy on pain relief.
Andras M Fulop, Seema Dhimmer, James R Deluca...
https://pubmed.ncbi.nlm.nih.gov/20842007/Actively Recruiting
Led by Medical University of South Carolina · Updated on 2025-11-12
39
Participants Needed
1
Research Sites
21 weeks
Total Duration
Researchers are evaluating whether multiple sessions of photobiostimulation using an Nd-YAG laser can improve healing after tooth extraction and alveolar ridge preservation. This study aims to measure the effects of laser treatment on wound healing by examining saliva markers, tracking changes in gingival wound size, and assessing post-operative pain and patient satisfaction. The research focuses on enhancing recovery and comfort following dental surgery. Participants will be divided into two groups one receiving standard tooth extraction and alveolar ridge preservation with sham laser control group, and the other receiving the same procedure combined with Nd-YAG laser photobiostimulation on days 1, 3, and 7 after surgery. The laser will be applied using a LightWalker device with specific settings, and both participants and operators will wear protective glasses during treatments. During the study, participants will have their saliva tested for inflammation markers from the day of surgery through day 7. Wound size changes will be monitored up to day 42, and pain levels will be recorded from day 3 to day 14 after surgery. Researchers will also survey patients about pain relief and satisfaction. The total participation period may last up to 42 days, including follow-up assessments to observe healing progress and safety.
CONDITIONS
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
P
Pinar Emecen-Huja
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Medical University of South Carolina
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Nd:YAG Laser Photobiostimulation | Standard Care (No Laser) |
|---|---|---|
| What it is | Low-level Nd:YAG laser (1064 nm, MSP, 0.5 W, 10 Hz) applied to the gingiva using a LightWalker® device immediately after tooth extraction and alveolar ridge preservation. Treated areas receive laser on day 1, day 3, and day 7, with operators also using protective eyewear. | Standard care after tooth extraction and alveolar ridge preservation, without any laser photobiostimulation. |
| Role in the trial | Investigational intervention arm, receiving Nd:YAG laser in addition to standard post-extraction care. | Comparator arm for measuring outcomes against standard post-extraction care without laser treatment. |
| Primary use | To promote wound healing, reduce inflammation, and manage post-surgical pain after tooth extraction by using targeted laser energy on the gum tissue. | To support natural gum healing and prevent complications after tooth extraction with routine care measures, but without the use of laser photobiostimulation. |
| How it is given or performed | Laser delivered to the extraction site using a Genova handpiece, 1 cm from the tissue, for 1 minute per 1 cm² on three separate days by trained staff. Participants and staff wear protective glasses. | Participants follow recommended home and clinic instructions for routine healing after extraction, with no use of laser devices. |
| Evidence status | Growing published evidence suggests that low-level laser therapies, including Nd:YAG, can reduce post-operative pain and support oral wound healing. Meta-analyses and RCTs indicate pain relief and biological effects, but data on alveolar ridge preservation post-extraction remain limited. | Routine post-extraction care is supported by longstanding clinical experience and guideline-based protocols, but does not include laser therapy for wound healing or pain reduction in standard practice. |
| Important limitations | Clinical benefit for Nd:YAG laser photobiostimulation in tooth extraction healing is not yet established. Evidence is mainly from small RCTs or non-extraction models; outcomes may vary based on device settings, operator skill, and wound characteristics. | Standard healing after extraction can be slow or accompanied by pain and inflammation, and does not actively accelerate tissue recovery. Lacks specific intervention for optimizing wound healing or reducing acute pain beyond routine practice. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 7 days
Participants undergo tooth extraction and alveolar ridge preservation. Low-level laser therapy or a sham laser is applied on the day of extraction, and then on day 3 and day 7 to support healing at the treatment site.
3 visits (in-person) on day 1, day 3, and day 7
Duration - Up to 42 days
Participants are monitored for wound healing and post-operative pain after the treatment period.
Visits to assess wound healing and pain typically occur from day 3 through day 42
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/27045437/Medical University of South Carolina
Lead Sponsor