Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial.
Afnan Abdulkareem Hussain, Ahmed Fadhel Al-Quisi, Ali A Abdulkareem
https://pubmed.ncbi.nlm.nih.gov/38179035/Actively Recruiting
Led by University of Ostrava · Updated on 2026-05-27
80
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are studying how to best preserve the bone in the jaw after tooth extraction, a process that typically causes significant bone loss over time. This randomized clinical study compares four common methods of alveolar ridge preservation to see which maintains bone volume most effectively for future dental prosthetics or implants. The study involves adult patients who need tooth extractions excluding wisdom teeth and measures bone changes using calibrated CBCT imaging before extraction and six months afterward. The study compares four treatment approaches following minimally traumatic tooth extraction 1 natural healing with stitches only control group, 2 filling the wound with a collagen sponge secured by stitches, 3 filling the wound with a tricalcium phosphate xenograft covered by a collagen sponge and stitched, and 4 filling the wound with grounded autogenous dentin covered with a collagen sponge and stitched. Each patients alveolar ridge dimensions will be assessed before extraction and half a year later to evaluate changes in bone width and height at specific depths. Participants will undergo tooth extraction and receive one of the four treatments randomly assigned. Their bone dimensions will be measured using CBCT scans before extraction and six months post-extraction. Additional patient factors like periodontal type and soft tissue characteristics will be recorded for subgroup analysis. The primary outcome is the change in alveolar bone width at six months, helping researchers understand which method best preserves bone after tooth removal.
CONDITIONS
Socket Preservation Using Autogenous Dentin
P
Petr Jalůvka, MDDr.
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University of Ostrava
Lead Sponsor
University Hospital Ostrava
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure with healing monitored over 6 months
Participants undergo tooth extraction followed by one of four treatments: spontaneous healing secured with a stitch, application of a collagen sponge, application of tricalcium phosphate xenograft covered with collagen sponge, or application of autogenous dentin covered with collagen sponge. The wound is secured with a stitch in all cases.
1 treatment visit and follow-up visits over 6 months
Duration - 6 months
Participants have alveolar ridge dimensions measured using CBCT before extraction and again after six months to evaluate bone width and height changes.
2 visits (baseline and 6 months post-treatment)
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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https://pubmed.ncbi.nlm.nih.gov/37455372/University of Ostrava
Lead Sponsor
University Hospital Ostrava
Collaborating Sponsor