Actively Recruiting

Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID07608289

Socket Preservation After Tooth Extraction Using Autogenous Dentin Compared With Collagen Sponge and Tricalcium Phosphate Techniques

Led by University of Ostrava · Updated on 2026-05-27

80

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

Sponsors

U

University of Ostrava

Lead Sponsor

U

University Hospital Ostrava

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying how to best preserve the bone in the jaw after tooth extraction, a process that typically causes significant bone loss over time. This randomized clinical study compares four common methods of alveolar ridge preservation to see which maintains bone volume most effectively for future dental prosthetics or implants. The study involves adult patients who need tooth extractions (excluding wisdom teeth) and measures bone changes using calibrated CBCT imaging before extraction and six months afterward. The study compares four treatment approaches following minimally traumatic tooth extraction: 1) natural healing with stitches only (control group), 2) filling the wound with a collagen sponge secured by stitches, 3) filling the wound with a tricalcium phosphate xenograft covered by a collagen sponge and stitched, and 4) filling the wound with grounded autogenous dentin covered with a collagen sponge and stitched. Each patient's alveolar ridge dimensions will be assessed before extraction and half a year later to evaluate changes in bone width and height at specific depths. Participants will undergo tooth extraction and receive one of the four treatments randomly assigned. Their bone dimensions will be measured using CBCT scans before extraction and six months post-extraction. Additional patient factors like periodontal type and soft tissue characteristics will be recorded for subgroup analysis. The primary outcome is the change in alveolar bone width at six months, helping researchers understand which method best preserves bone after tooth removal.

CONDITIONS

Brief Title

Socket Preservation Using Autogenous Dentin

Who Can Participate

Age: 18Years - 70Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 18 and 70 years
  • No active periodontitis (gum disease)
  • Signed informed consent to participate
  • Need for extraction of teeth other than third molars (not wisdom teeth)
  • Patients requesting only standard or reimbursed dental care
Not Eligible

You will not qualify if you...

  • Drug or alcohol abuse
  • Ongoing chemotherapy treatment
  • Ongoing radiotherapy treatment
  • Pregnancy
  • Current treatment for osteoporosis or other biological therapy with risk of medication-related osteonecrosis of the jaw (MRONJ)
  • Low compliance with treatment or study procedures
  • Patients requesting premium dental care

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Single procedure with healing monitored over 6 months

Participants undergo tooth extraction followed by one of four treatments: spontaneous healing secured with a stitch, application of a collagen sponge, application of tricalcium phosphate xenograft covered with collagen sponge, or application of autogenous dentin covered with collagen sponge. The wound is secured with a stitch in all cases.

1 treatment visit and follow-up visits over 6 months

Follow-up

Duration - 6 months

Participants have alveolar ridge dimensions measured using CBCT before extraction and again after six months to evaluate bone width and height changes.

2 visits (baseline and 6 months post-treatment)

Trial Site Locations

Total: 1 location

1

University Hospital Ostrava

Ostrava, Czechia, 70852

Actively Recruiting

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Research Team

P

Petr Jalůvka, MDDr.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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