Study of a Rhythm-Based Exercise Program to Prevent Falls, Improve Bone and Nerve Health, and Reduce Heart Risks in People Aged 65 and Older with Diabetes

What this Trial Is About

This research aims to evaluate the effects of comprehensive screening and multicomponent interventions on preventing falls, improving bone health, nerve function, and cardiovascular outcomes in people with diabetes aged 65 and older. Diabetes increases the risk of falls, fractures, and cardiovascular disease, yet these risks are not well studied together. The trial uses a novel, multidimensional approach to address these challenges through integrated care and long-term follow-up. Participants undergo detailed baseline assessments including fall risk evaluation, bone density scans using DXA, neuropathy tests, and cardiovascular profiling with imaging like MRI and seismocardiography. Based on these results, participants are randomized to different groups, including one that receives the RYMA exercise programa 26-week regimen combining rhythm-based cognitive-motor training, strength, balance, coordination, and daily activity exercises set to music. Pharmacological treatments for osteoporosis and cardiovascular risk management with medications such as SGLT2 inhibitors and GLP-1 receptor agonists are also tailored to participant needs. Throughout the study, participants are assessed at 26 weeks, 52 weeks, 2 years, and 5 years. Evaluations include fall rates, bone mineral density, nerve function, cardiovascular events, gait and balance analysis, cognitive and physical tests, and quality of life measures. Continuous monitoring and follow-up ensure understanding of both short- and long-term effects. The study also tracks participants adherence to interventions and explores mechanisms behind fall reduction and health improvements.

Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes