Lung Cancer in France.
Jean-Louis Pujol, Pascal-Alexandre Thomas, Philippe Giraud...
https://pubmed.ncbi.nlm.nih.gov/33384058Actively Recruiting
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-09-02
50
Participants Needed
1
Research Sites
4 weeks
Total Duration
Researchers are investigating how different surgical methods used during lobectomies for non-small cell lung cancer affect patients' posture and breathing coordination. The study focuses on comparing traditional thoracotomy with robotic-assisted thoracoscopic surgery (RATS) to understand why minimally invasive techniques might lead to better quality of life and fewer post-operative complications. The trial aims to explore the underlying mechanisms involving the rib cage and diaphragm, which play key roles in both posture stability and breathing function. Participants will undergo either a conventional postero-lateral thoracotomy or a minimally invasive RATS for lung tissue removal. Before and after surgery, patients will receive several assessments including low radiation 2D/3D imaging of the rib cage and spine, movement analysis with an optoelectronic camera, and stabilometric measurements using a strength platform. These procedures will help compare changes in thoracic kyphosis, rib cage structure, and posture-respiratory coupling between the two surgical approaches. Participants will be evaluated one week before surgery and again four weeks after surgery through imaging and movement assessments. Researchers will measure specific outcomes such as spinal alignment angles, rib cage width and volume, and center of pressure displacement to assess postural and respiratory function. The study does not involve masking or randomization, and the total observation period includes pre- and post-operative evaluations to monitor recovery and physiological adaptation related to the surgical technique used.
CONDITIONS
Impact of Surgical Approach on Adaptation of Posture-respiratory Coupling
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery plus hospital stay duration
Participants undergo major lung resection through either conventional postero-lateral thoracotomy or minimally invasive robotic-assisted thoracoscopic surgery (RATS).
1 surgical visit (in-person)
Duration - Approximately 4 weeks after surgery
Participants have assessments of posture-respiratory coupling and rib cage structure using imaging and movement analysis before and after surgery.
2 visits: 1 visit about 1 week before surgery and 1 visit about 4 weeks after surgery
Total: 1 location
1
Department of Thoracic and Vascular Surgery Tenon University Hospital
Paris, France, 75020
Actively Recruiting
H
Harry ETIENNE, M.D., PhD Degree
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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