Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06276530

Impact of Surgical Approach on Adaptation of Posture-respiratory Coupling in Resectable Lung Non-Small Cell Carcinoma

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-09-02

50

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating how different surgical methods used during lobectomies for non-small cell lung cancer affect patients' posture and breathing coordination. The study focuses on comparing traditional thoracotomy with robotic-assisted thoracoscopic surgery (RATS) to understand why minimally invasive techniques might lead to better quality of life and fewer post-operative complications. The trial aims to explore the underlying mechanisms involving the rib cage and diaphragm, which play key roles in both posture stability and breathing function. Participants will undergo either a conventional postero-lateral thoracotomy or a minimally invasive RATS for lung tissue removal. Before and after surgery, patients will receive several assessments including low radiation 2D/3D imaging of the rib cage and spine, movement analysis with an optoelectronic camera, and stabilometric measurements using a strength platform. These procedures will help compare changes in thoracic kyphosis, rib cage structure, and posture-respiratory coupling between the two surgical approaches. Participants will be evaluated one week before surgery and again four weeks after surgery through imaging and movement assessments. Researchers will measure specific outcomes such as spinal alignment angles, rib cage width and volume, and center of pressure displacement to assess postural and respiratory function. The study does not involve masking or randomization, and the total observation period includes pre- and post-operative evaluations to monitor recovery and physiological adaptation related to the surgical technique used.

CONDITIONS

Brief Title

Impact of Surgical Approach on Adaptation of Posture-respiratory Coupling

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients admitted for major lung resection
  • Surgical approach by conventional postero-lateral thoracotomy
  • Surgical approach by minimally invasive robotic-assisted thoracoscopic surgery (RATS)
Not Eligible

You will not qualify if you...

  • Extended lung resection

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Day of surgery plus hospital stay duration

Participants undergo major lung resection through either conventional postero-lateral thoracotomy or minimally invasive robotic-assisted thoracoscopic surgery (RATS).

1 surgical visit (in-person)

Post-operative Follow-up

Duration - Approximately 4 weeks after surgery

Participants have assessments of posture-respiratory coupling and rib cage structure using imaging and movement analysis before and after surgery.

2 visits: 1 visit about 1 week before surgery and 1 visit about 4 weeks after surgery

Trial Site Locations

Total: 1 location

1

Department of Thoracic and Vascular Surgery Tenon University Hospital

Paris, France, 75020

Actively Recruiting

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Research Team

H

Harry ETIENNE, M.D., PhD Degree

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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Published Research Related To This Trial

Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

P E Postmus, K M Kerr, M Oudkerk...

https://pubmed.ncbi.nlm.nih.gov/28881918