Actively Recruiting
A Study of Adebrelimab in Combination with Chemo with or Without Bevacizumab Neoadjuvant Therapy for Resectable NSCLC
Led by The First Affiliated Hospital of Guangzhou Medical University · Updated on 2025-01-15
60
Participants Needed
1
Research Sites
274 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, multicenter, randomized, uncontrolled Phase II study to assess the efficacy and safety of adebrelimab in combination with chemotherapy with or without bevacizumab for the treatment of resectable Stage II-IIIB (T3N2) NSQ-NSCLC and to explore biomarkers associated with efficacy.
CONDITIONS
Official Title
A Study of Adebrelimab in Combination with Chemo with or Without Bevacizumab Neoadjuvant Therapy for Resectable NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Resectable non-squamous non-small cell lung cancer
- Age between 18 and 65 years
- Male or female
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- No prior surgery, chemotherapy, radiotherapy, or biological treatment for non-squamous non-small cell lung cancer
- Adequate lung function for planned lung surgery
You will not qualify if you...
- Small cell lung cancer or squamous non-small cell lung cancer
- Previous treatment with anti-PD1, anti-PDL1, anti-CTLA4 antibodies, or similar drugs
- Prior use of anti-angiogenic drugs
- Allergy to any component of the study drugs or chemotherapy
- Presence of any severe or uncontrolled medical condition
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
Actively Recruiting
Research Team
J
Jianxing He
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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