Study of How Knee Osteoarthritis Affects Walking Pain and Mobility in Adults Aged 45 to 80

What this Trial Is About

Researchers are investigating why some people with knee osteoarthritis experience more severe and disabling walking pain than others, despite similar levels of joint degeneration. The study focuses on identifying the biological, psychological, and social factors that contribute to walking pain and limitations in function, with a special interest in how brain processes may influence these differences. This observational study aims to improve understanding of movement-related pain and functional limitations in knee osteoarthritis to help guide future treatments. Participants aged 45 to 80 years with moderate-to-severe knee osteoarthritis and chronic knee pain will take part in two study visits. During these visits, they will complete surveys, perform physical function tasks such as exercise and mobility assessments, and undergo various non-invasive evaluations including knee X-rays, MRI scans, brain imaging, sensory testing, and biomechanical assessments. The data collected will be analyzed to identify factors affecting walking pain and functional ability. Throughout the study, participants will be assessed on pain intensity during a six-minute walk test as the primary outcome. Additional measures include the distance walked during this test. Researchers will monitor participants physical performance, pain levels, and brain activity. The study will last over two visits and aims to provide insights that may lead to better physical therapy outcomes and improved health for people with knee osteoarthritis.

Individual Differences in Gait and Osteoarthritis Pain