Actively Recruiting
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Led by Novo Nordisk A/S · Updated on 2026-05-14
400
Participants Needed
82
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
CONDITIONS
Official Title
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female (sex at birth).
- Age 18 years or above at the time of signing the informed consent.
- Clinical diagnosis of knee osteoarthritis with radiographic changes (Kellgren Lawrence grades 2 to 3) in the target knee.
- Symptomatic knee osteoarthritis with pain starting more than 90 days before screening and pain in the target knee for more than 15 days in the last 30 days.
- Willing to complete a 72-hour washout period of analgesics before visits involving the pain questionnaire (acetaminophen up to 4 grams/day allowed as rescue medication until 24 hours before those visits).
You will not qualify if you...
- Glycated haemoglobin of 6.5% or higher at screening.
- History of type 1 or type 2 diabetes mellitus.
- Treatment with GLP-1 receptor agonists, dual GLP-1/GIP receptor agonists, or amylin analogues before screening.
- Any joint prosthesis or joint replacement in the target knee.
- Arthroscopy or injections into the target knee within 90 days before screening.
- Any other joint disease in the target knee including gout and pseudogout.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 82 locations
1
Arizona Research Center, Inc.
Phoenix, Arizona, United States, 85053
Actively Recruiting
2
Diablo Clinical Research, Inc.
Walnut Creek, California, United States, 94598
Actively Recruiting
3
Chase Medical Research LLC
Hamden, Connecticut, United States, 06517
Actively Recruiting
4
Chase Medical Research LLC
Waterbury, Connecticut, United States, 06708
Actively Recruiting
5
Zenith clinical research
Hollywood, Florida, United States, 33021
Actively Recruiting
6
CNS Healthcare
Jacksonville, Florida, United States, 32256
Actively Recruiting
7
Angels Clinical Research Institute
Miami Lakes, Florida, United States, 33016
Actively Recruiting
8
Hope Clin Res & Wellness
Conyers, Georgia, United States, 30094
Actively Recruiting
9
CenExel iResearch, LLC
Decatur, Georgia, United States, 30030
Actively Recruiting
10
Elite Clinical Trials
Blackfoot, Idaho, United States, 83221
Actively Recruiting
11
MedVadis Research Watertown
Waltham, Massachusetts, United States, 02451
Actively Recruiting
12
Jubilee Clinical Research, Inc.
Las Vegas, Nevada, United States, 89106
Actively Recruiting
13
Great Lakes Medical Research
Westfield, New York, United States, 14787
Actively Recruiting
14
Accellacare and KDCILM, LLC
Wilmington, North Carolina, United States, 28401
Actively Recruiting
15
Coastal Carolina Res Ctr
North Charleston, South Carolina, United States, 29405
Actively Recruiting
16
VIP Trials_San Antonio
San Antonio, Texas, United States, 78230
Actively Recruiting
17
Charlottesville Med Research
Charlottesville, Virginia, United States, 22911
Actively Recruiting
18
Health Res of Hampton Roads
Newport News, Virginia, United States, 23606
Actively Recruiting
19
Northwest Clinical Research Center
Bellevue, Washington, United States, 98007
Actively Recruiting
20
Emeritus Research Sydney
Botany, New South Wales, Australia, 2019
Actively Recruiting
21
Momentum Clinical Research Darlinghurst
Darlinghurst, New South Wales, Australia, 2010
Actively Recruiting
22
Kolling Institute
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
23
Heart of Australia
Chelmer, Queensland, Australia, 4068
Actively Recruiting
24
Coastal Digestive Health
Maroochydore, Queensland, Australia, 4558
Actively Recruiting
25
UMHAT Sveti Georgi EAD, Plovdiv
Plovdiv, Bulgaria, 4002
Actively Recruiting
26
MC Dr. Atanasov EOOD
Sofia, Bulgaria, 1231
Actively Recruiting
27
MC Excelsior OOD
Sofia, Bulgaria, 1407
Actively Recruiting
28
UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology
Sofia, Bulgaria, 1527
Actively Recruiting
29
MMA MHAT - Sofia, Rheumatology clinic
Sofia, Bulgaria, 1606
Actively Recruiting
30
UMHAT Sveti Ivan Rilski EAD, Rheumatology
Sofia, Bulgaria, 1612
Actively Recruiting
31
Laser Rejuvenation Clinics Inc.
Calgary, Alberta, Canada, T2W 4X9
Not Yet Recruiting
32
Dawson Clinical Research
Guelph, Ontario, Canada, N1H 1B1
Actively Recruiting
33
Hamilton Medical Rsrch Grp
Hamilton, Ontario, Canada, L8L 5G4
Not Yet Recruiting
34
Centre de Recherche Musculo
Trois-Rivières, Quebec, Canada, G8Z 1Y2
Actively Recruiting
35
Alpha Recherche Clinique - Lebourgneuf
Québec, Canada, G2J OC4
Actively Recruiting
36
Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme
Aarhus N, Denmark, 8200
Actively Recruiting
37
Frederiksberg Hospital - Parker Institutet (Artrose)
Frederiksberg, Denmark, 2000
Actively Recruiting
38
Sanos Clinic - Herlev
Herlev, Denmark, 2730
Actively Recruiting
39
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine
Chaïdári, Attica, Greece, 12461
Not Yet Recruiting
40
Laiko General Hospital Of Athens - 1st department of Internal Medicine
Athens, Greece, 115 27
Actively Recruiting
41
Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases
Athens, Greece, 11525
Actively Recruiting
42
General Hospital Of Athens Alexandra - Clinical Therapeutics
Athens, Greece, 11528
Actively Recruiting
43
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
Marousi, Greece, 15125
Actively Recruiting
44
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
Thessaloniki, Greece, 54635
Actively Recruiting
45
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
Thessaloniki, Greece, 57001
Actively Recruiting
46
AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Medicina Interna e Nutrizione Clinica
Naples, Campania, Italy, 80131
Not Yet Recruiting
47
Ospedale Civile di Baggiovara - UOC Endocrinologia
Modena, Emilia-Romagna, Italy, 41126
Not Yet Recruiting
48
Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo
Udine, Friuli Venezia Giulia, Italy, 33100
Not Yet Recruiting
49
Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia
Rome, Lazio, Italy, 00128
Not Yet Recruiting
50
Auxologico San Luca - Endocrinologia e Malattie del Metabolismo
Milan, Lombardy, Italy, 20149
Not Yet Recruiting
51
Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica
San Donato Milanese, Lombardy, Italy, 20097
Not Yet Recruiting
52
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia
Verona, Veneto, Italy, 37126
Not Yet Recruiting
53
"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
Bialystok, Podlaskie Voivodeship, Poland, 15-351
Actively Recruiting
54
"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
Bialystok, Podlaskie Voivodeship, Poland, 15-351
Not Yet Recruiting
55
ClinicMed Daniluk, Nowak Spółka Komandytowa
Bialystok, Poland, 15-879
Actively Recruiting
56
ClinicMed Daniluk, Nowak Spółka Komandytowa
Bialystok, Poland, 15-879
Not Yet Recruiting
57
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, Poland, 85-605
Actively Recruiting
58
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, Poland, 85-605
Not Yet Recruiting
59
CenterMed Kraków Sp. z o.o.
Krakow, Poland, 31-530
Actively Recruiting
60
CenterMed Kraków Sp. z o.o.
Krakow, Poland, 31-530
Not Yet Recruiting
61
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
Krakow, Poland, 31-826
Actively Recruiting
62
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
Krakow, Poland, 31-826
Not Yet Recruiting
63
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
Warsaw, Poland, 02-637
Actively Recruiting
64
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
Warsaw, Poland, 02-637
Not Yet Recruiting
65
Instituto Medico Quirurgico San Rafael
A Coruña, Spain, 15006
Actively Recruiting
66
Hospital Germans Trias i Pujol
Badalona, Spain, 08916
Not Yet Recruiting
67
Hospital Naval Ferrol
Ferrol, Spain, 15405
Actively Recruiting
68
Centro Especialidades Hermanos Sangro
Madrid, Spain, 28038
Not Yet Recruiting
69
Hospital Quirónsalud Málaga
Málaga, Spain, 29004
Actively Recruiting
70
Hospital Infanta Sofía
San Sebastián de Los Reyes (Madrid), Spain, 28702
Actively Recruiting
71
Hospital Universitario Marqués de Valdecilla
Santander, Spain, 39008
Actively Recruiting
72
Hospital HM La Esperanza
Santiago de Compostela, Spain, 15705
Actively Recruiting
73
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
Seville, Spain, 41003
Actively Recruiting
74
H. Infanta Luisa_Endocrino y Obesidad
Seville, Spain, 41010
Actively Recruiting
75
Hospital General de Valencia
Valencia, Spain, 46014
Actively Recruiting
76
Ankara Üniversitesi Sağlık Uygulama ve Araştırma Hastaneleri- Fiziksel Tıp ve Rehabilitasyon
Altındağ/Ankara, Turkey (Türkiye), 06230
Actively Recruiting
77
İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
Bahçelievler/İstanbul, Turkey (Türkiye), 34186
Actively Recruiting
78
Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon
Çankaya/Ankara, Turkey (Türkiye), 06800
Actively Recruiting
79
Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi-Fiziksel Tıp ve Rehabilitasyon
Kepez/Çanakkale Merkez/Çanakkale, Turkey (Türkiye), 17110
Not Yet Recruiting
80
İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi-Fiziksel Tıp ve Rehabilitasyon
Merkez/Battalgazi/Malatya, Turkey (Türkiye), 44280
Not Yet Recruiting
81
Karadeniz Teknik Üniversitesi Farabi Hastanesi- Fiziksel Tıp ve Rehabilitasyon
Trabzon Merkez/Ortahisar/Trabzon, Turkey (Türkiye), 61080
Actively Recruiting
82
Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon
Yuregir/Adana, Turkey (Türkiye), 01060
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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