Early inhaled glucocorticoid therapy to prevent bronchopulmonary dysplasia.
C H Cole, T Colton, B L Shah...
https://pubmed.ncbi.nlm.nih.gov/10099142Completed
Phase 3
Age: 0 - 1Year
All Genders
ID00000576
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-02-18
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To test if inhaled glucocorticoids, early in the course of respiratory failure in premature infants, permit normal lung growth and differentiation, thus preventing development of bronchopulmonary dysplasia.
CONDITIONS
Official Title
Inhaled Beclomethasone to Prevent Chronic Lung Disease
Who Can Participate
Age: 0 - 1Year
All Genders
Eligibility Criteria
You may qualify if you...
Premature boy and girl infants with birth weight less than 1,251 grams, gestational age less than 33 weeks, and postnatal age three to fourteen days, who continue to require mechanical ventilation with an emphasis on enrollment at three days.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia.
G K Gupta, C H Cole, S Abbasi...
https://pubmed.ncbi.nlm.nih.gov/11015126Meta-analysis of dexamethasone therapy started in the first 15 days of life for prevention of chronic lung disease in premature infants.
J M Arias-Camison, J Lau, C H Cole...
https://pubmed.ncbi.nlm.nih.gov/10495332Adrenal function in premature infants during inhaled beclomethasone therapy.
C H Cole, B Shah, S Abbasi...
https://pubmed.ncbi.nlm.nih.gov/10393606