Actively Recruiting
The American Lung Association (ALA) Lung Health Cohort
Led by Johns Hopkins University · Updated on 2026-02-04
4000
Participants Needed
37
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting the American Lung Association (ALA) Lung Health Cohort, a multi-center, long-term observational study focusing on young adults aged 25 to 35 without severe lung disease. The study aims to understand lung health by examining various factors such as environmental exposures, physical activity, biomarkers, and respiratory cell activity to identify early markers and targets to prevent chronic lung diseases. Participants will undergo an initial baseline assessment to measure lung function, including pre-bronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). After this, regular remote contacts through text, email, mail, or phone will be used to follow up with participants for up to 4.5 years. Pending additional funding, the study may be extended beyond 5 years to explore long-term changes in lung health. During the study, participants will provide contact information and undergo lung function tests. Follow-up data will be collected remotely to monitor lung health over time. Researchers will track lung function measures and gather information on environmental and lifestyle factors. Safety and participant status will be monitored regularly, with the total study duration potentially extending beyond 5 years depending on funding.
CONDITIONS
Brief Title
American Lung Association (ALA) Lung Health Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 25-35 years at the time of the baseline examination
- Able to read and understand English or Spanish
- Has a social security number
- Resident (citizen or non-citizen) of the United States for at least 12 months prior to examination
- Willing to provide contact information for at least 2 proxies who can verify your whereabouts and status
You will not qualify if you...
- Severe asthma requiring high-dose ICS/LABA or add-on LAMA therapy
- Three or more unscheduled healthcare visits for asthma in the past 12 months
- One asthma hospitalization in the past 12 months
- History of chronic lung diseases other than asthma, including COPD, cystic fibrosis, pulmonary fibrosis, or pulmonary hypertension
- Current pregnancy
- History of cancer other than non-melanoma skin cancer
- Diagnosed cardiovascular diseases like congenital heart disease or coronary heart disease
- Inability or unwillingness to provide informed consent or perform study measurements
- Inability to be contacted by phone or email
- Any condition that puts the participant at risk as judged by a physician
- Institutionalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including measurements of lung function and collection of health-related data.
1 baseline visit (in-person)
Duration - Up to 4.5 years, with possible extension beyond 5 years
Participants are contacted remotely at regular intervals to collect follow-up information on lung health and other factors over several years.
Regular remote contacts via text message, email, mail, or phone
Trial Site Locations
Total: 37 locations
1
University Of Alabama
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
University of Arizona-Tuscon
Tucson, Arizona, United States, 85724
Actively Recruiting
3
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
4
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
5
University of Colorado
Aurora, Colorado, United States, 80045
Active, Not Recruiting
6
National Jewish Health
Denver, Colorado, United States, 80206
Actively Recruiting
7
Nemours Children's Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
8
University of Florida, Jacksonville
Jacksonville, Florida, United States, 32209
Actively Recruiting
9
University of Illinois at Chicago
Chicago, Illinois, United States, 60608
Actively Recruiting
10
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
11
Rush Universtiy
Chicago, Illinois, United States, 60612
Actively Recruiting
12
University of Chicago
Chicago, Illinois, United States, 60637
Withdrawn
13
St. Vincent's Health System
Indianapolis, Indiana, United States, 46260
Withdrawn
14
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
15
University of Kansas
Kansas City, Kansas, United States, 66103
Actively Recruiting
16
Johns Hopkins University
Baltimore, Maryland, United States, 21218
Actively Recruiting
17
Brigham and Women's
Boston, Massachusetts, United States, 02115
Withdrawn
18
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
19
Presbyterian Brooklyn Methodist Hospital
Brooklyn, New York, United States, 11215
Not Yet Recruiting
20
New York Medical College
Hawthorne, New York, United States, 10532
Actively Recruiting
21
New York University
New York, New York, United States, 10016
Withdrawn
22
Mt. Sinai, NYC
New York, New York, United States, 10029
Actively Recruiting
23
Columbia University
New York, New York, United States, 10032
Not Yet Recruiting
24
Cornell University
New York, New York, United States, 10032
Actively Recruiting
25
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
26
University of North Carolina Hospital
Chapel Hill, North Carolina, United States, 27517
Active, Not Recruiting
27
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
28
Wake Forest School of Medicine
Winston-Salem, North Carolina, United States, 27104
Actively Recruiting
29
Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
30
Temple University
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
31
University of Pittsburg-Emphysema/COPD Research Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
32
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
33
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37235
Actively Recruiting
34
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
35
University of Vermont
Colchester, Vermont, United States, 05446
Actively Recruiting
36
University of Washington
Seattle, Washington, United States, 98108
Not Yet Recruiting
37
University of Wisconsin Madison
Madison, Wisconsin, United States, 53792
Withdrawn
Research Team
E
Elizabeth Sugar, PhD
C
Curt Reynolds, MAS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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