Actively Recruiting
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)
Led by Hui-Sheng Chen · Updated on 2025-08-21
30
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.
CONDITIONS
Official Title
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Major neurologic deficits with NIH Stroke Scale (NIHSS) score between 6 and 20
- Missed recanalization therapy (intravenous thrombolysis or endovascular treatment) or worsening stroke symptoms within 48 hours (increase in NIHSS score by more than 4)
- Premorbid modified Rankin Scale (mRS) score of 0 or 1
- Signed informed consent provided
You will not qualify if you...
- Modified Rankin Scale score greater than 2 due to previous stroke
- Patients who have had intravenous thrombolysis or endovascular treatment
- Coagulation disorders, systemic bleeding tendency, or thrombocytopenia (platelet count below 80,000/mm3)
- Severe liver or kidney dysfunction, including elevated liver enzymes (ALT or AST more than twice the upper limit) or serum creatinine (more than 1.5 times the upper limit), or requiring dialysis
- Severe high blood pressure (systolic over 200 mmHg or diastolic over 110 mmHg)
- Assessed as unsuitable for the study by the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China, 110016
Actively Recruiting
Research Team
H
Hui-Sheng T Chen, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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