Evaluating Intravesical Aminophylline to Help Urgent Ureteral Stent Placement in Adults with Acute Kidney Blockage from Ureteral Stones

What this Trial Is About

Researchers are studying acute calculous anuria, a serious urological emergency caused by blockage of urine flow due to ureteral stones in a solitary functioning kidney or both ureters. This trial evaluates whether using intravesical aminophylline can help make urgent retrograde ureteral stenting easier and more successful in adult patients with this condition. The study is a prospective, randomized, double-blind controlled trial aiming to improve urine drainage and prevent kidney damage. Participants will be randomly assigned to receive either intravesical aminophylline diluted in normal saline or a placebo saline solution before undergoing retrograde ureteral stenting. Under anesthesia, the assigned solution is instilled into the bladder and retained for 5 minutes before attempting to place a Double-J ureteral stent through the ureter to bypass the obstructing stone. The procedure is done under fluoroscopic guidance, and success is defined as placing the stent without needing a more invasive drainage method. During the trial, researchers will monitor technical success, time taken to place the stent, any complications during the procedure, changes in kidney function over 72 hours, pain levels, pain medication use, and whether alternative drainage is needed. The study involves clinical evaluations, imaging confirmation, laboratory tests for kidney function, and pain assessments to understand how well the treatment works and its effects after stenting.

Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria