Actively Recruiting
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
Led by Guy's and St Thomas' NHS Foundation Trust · Updated on 2024-12-03
100
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.
CONDITIONS
Official Title
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged over 18 years
- Female participants can be pre-menopausal, peri-menopausal, or post-menopausal
- Participants willing and able to give informed consent
- Healthy controls with less than 10 pack-year smoking history (without asthma or COPD)
You will not qualify if you...
- Current or suspected pulmonary tuberculosis, HIV, Hepatitis B, or Hepatitis C
- Harmful alcohol or recreational drug abuse as per NHS definition
- History of psychiatric, medical, or surgical disorders
- Pregnant women
- Unable to provide written informed consent
- History of advanced medical conditions with expected prognosis less than 3 years
- History of active cancer
- Patients on long-term oxygen (ambulatory oxygen)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Guys & St Thomas NHS Foundation Trust
London, United Kingdom, SE1 7EH
Actively Recruiting
Research Team
G
Gill Radcliffe Ms, MRes
CONTACT
C
Chris Mwasuku
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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