Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive, in People With Knee Pain, and in People With Fibromyalgia Syndrome (Pain-Neural Drive)

What this Trial Is About

Researchers are investigating the role of central pain hypersensitivity and its impact on nerve signaling to skeletal muscles in adults aged 40 years or older. The focus is on people with chronic knee pain, fibromyalgia, and healthy volunteers without chronic pain. The study aims to understand whether changes in nerve signaling relate to physical function and disability in these groups. The study involves two visits to a medical research facility. During the first visit, participants undergo screening, provide consent, and complete questionnaires along with familiarization exercises. The second visit includes detailed sensory testing, muscle electrical activity measurements using electrodes during static muscle contractions, and physical performance tests. A temporary pain stimulus will also be applied during muscle testing to assess its influence on neuromuscular function. Participants will complete questionnaires on pain severity, disability, fatigue, and physical activity. Physical tests include walking, rising from a chair, and balancing. Researchers will measure pain thresholds, muscle motor unit firing characteristics, and physical performance at baseline. The total involvement includes two visits with assessments of pain sensitivity, neuromuscular control, and physical function to explore how chronic pain affects muscle nerve signaling and mobility.

Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive