Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic.
Terry L Wahls, Catherine A Chenard, Linda G Snetselaar
https://pubmed.ncbi.nlm.nih.gov/30736445Actively Recruiting
Phase Not Applicable
Age: 18Years - 100Years
All Genders
ID05057676
Evaluation of an Online Course to Support Healthier Diet and Self-Care in Multiple Sclerosis and Related Conditions
Led by Terry L. Wahls · Updated on 2026-03-11
400
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research aims to evaluate how effective an online program is at improving diet and self-care for people with multiple sclerosis (MS), clinically isolated syndrome (CIS), fibromyalgia, long-term effects of COVID-19, and cancer survivors with ongoing fatigue. It focuses on delivering dietary education and support to a larger and more diverse group, including those with limited access to specialized dietitians. The study uses a randomized single-blind waitlist control design to compare health outcomes over short-term (3 months) and long-term (6 months) periods. Participants will be randomly assigned to either start the online course immediately or after a delay. The course includes modules on diet plans such as the modified Paleolithic, nutrient-dense vegetarian, and Mediterranean diets, as well as strategies for stress reduction, exercise, and improving resilience. Alongside the course, participants will access seven weekly group support videos. The program is entirely virtual, allowing participants to complete exercises, personal assessments, and course materials online. During the study, participants will complete baseline assessments and follow-up virtual visits at months 0, 3, and 6. They will fill out online questionnaires measuring fatigue and quality of life, and complete dietary assessments using a web-based tool. Researchers will track changes in mental and physical health quality of life scores and fatigue levels using validated scales. The study lasts six months in total and includes ongoing monitoring through online tools and group support.
CONDITIONS
Brief Title
Autoimmune Intervention Mastery Course Study
Who Can Participate
Age: 18Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Self-reported diagnosis of multiple sclerosis or clinically isolated syndrome
- Self-reported post-acute sequelae of COVID-19 (long COVID) with confirmed COVID-19 infection, persisting fatigue, and neuropsychiatric symptoms lasting longer than 6 months
- Self-reported diagnosis of fibromyalgia confirmed by a treating specialist or primary care provider
You will not qualify if you...
AI-Screening
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1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 virtual visit
Outpatient Treatment
Duration - 7 weeks
Participants work through an online course with modules on diet, self-care, exercise, stress reduction, and resilience strategies. They also access weekly group support videos released over 7 weeks.
Access to online course materials throughout; 7 weekly video sessions
Monitoring
Duration - 6 months
Participants complete online questionnaires assessing fatigue, quality of life, and dietary habits at baseline, 3 months, and 6 months to evaluate the impact of the online program.
3 virtual visits at months 0, 3, and 6
Trial Site Locations
Total: 1 location
1
Univeristy of Iowa
Iowa City, Iowa, United States, 52246
Actively Recruiting
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Research Team
S
Study Coordinator
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Published Research Related To This Trial
Dietary approaches to treat MS-related fatigue: comparing the modified Paleolithic (Wahls Elimination) and low saturated fat (Swank) diets on perceived fatigue in persons with relapsing-remitting multiple sclerosis: study protocol for a randomized controlled trial.
Terry Wahls, Maria O Scott, Zaidoon Alshare...
https://pubmed.ncbi.nlm.nih.gov/29866196Nutrient Composition Comparison between a Modified Paleolithic Diet for Multiple Sclerosis and the Recommended Healthy U.S.-Style Eating Pattern.
Catherine A Chenard, Linda M Rubenstein, Linda G Snetselaar...
https://pubmed.ncbi.nlm.nih.gov/30832289Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet.
Tyler J Titcomb, Babita Bisht, David D Moore...
https://pubmed.ncbi.nlm.nih.gov/32575774Impact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: The WAVES randomized parallel-arm clinical trial.
Terry L Wahls, Tyler J Titcomb, Babita Bisht...
https://pubmed.ncbi.nlm.nih.gov/34377527A Modified MCT-Based Ketogenic Diet Increases Plasma β-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study.
Jennifer E Lee, Tyler J Titcomb, Babita Bisht...
https://pubmed.ncbi.nlm.nih.gov/32213121A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue.
Babita Bisht, Warren G Darling, Ruth E Grossmann...
https://pubmed.ncbi.nlm.nih.gov/24476345Effects of a multimodal intervention on gait and balance of subjects with progressive multiple sclerosis: a prospective longitudinal pilot study.
Babita Bisht, Warren G Darling, Emily C White...
https://pubmed.ncbi.nlm.nih.gov/30050380Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study.
Amanda K Irish, Constance M Erickson, Terry L Wahls...
https://pubmed.ncbi.nlm.nih.gov/30050374Evaluation of a web-based program for the adoption of wellness behaviors to self-manage fatigue and improve quality of life among people with multiple sclerosis: A randomized waitlist-control trial.
Tyler J Titcomb, Max Sherwood, Mary Ehlinger...
https://pubmed.ncbi.nlm.nih.gov/37399671