Actively Recruiting
Characterizing Tumor-Draining Lymph Nodes and Immune Sites in Renal Cell Carcinoma
Led by Yale University · Updated on 2026-02-03
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how T cells behave and interact in kidney cancer, specifically Renal Cell Carcinoma (RCC). The study focuses on analyzing T cells from tumor-draining lymph nodes to understand their role in fighting cancer. Data and tissue samples collected will help explore kidney cancer biology, discover new biomarkers, identify potential therapeutic targets, and improve knowledge of genetic and biological factors in kidney cancers. This study collects tissue samples from patients with confirmed or suspected RCC at various treatment points such as before treatment, during response, or when resistance or toxicity occurs. Samples include blood, tumor tissue, non-cancerous kidney tissue, draining lymph nodes, and regional non-draining lymph nodes. These specimens are obtained during routine clinical procedures or other clinical trials for research analysis. Participants will provide consent for tissue and blood collection, which occurs alongside their standard care or clinical trial treatments. Researchers will analyze these samples to study molecular profiles, immune responses, therapy resistance, and toxicity biomarkers over a 24-month period. The study includes ongoing evaluation of tumor and lymph node tissues to better understand kidney cancer and improve future treatments.
CONDITIONS
Brief Title
Investigation of Lymph Node Biology in Kidney Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with known or suspected kidney cancer
- Referred to Yale Genitourinary Oncology or related departments
- Receiving clinical evaluation, treatment, surgery, or procedures at Yale New Haven Hospital or Smilow Cancer Hospital
- Consent provided by study investigators or authorized personnel
You will not qualify if you...
- Under 18 years of age
- Known pregnancy or actively breastfeeding
- Allergy or hypersensitivity to iodine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - At time of routine clinical procedures
Participants provide tissue and blood specimens during routine clinical procedures, including surgery. Samples collected may include tumor tissue, adjacent non-malignant kidney tissue, draining lymph nodes, regional non-draining lymph nodes, and peripheral blood for immune analysis.
1 visit (in-person) during surgery or other clinical procedures
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
Research Team
S
Stephanie Ladd
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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