Actively Recruiting
Laparoscopic Versus Open Nephrectomy: Clinical Effectiveness and Cost Analysis
Led by Menoufia University · Updated on 2026-03-11
60
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating and comparing the clinical effectiveness and costs of two surgical methods for kidney removal: laparoscopic nephrectomy and open nephrectomy. The study focuses on outcomes such as operative time, blood loss, hospital stay duration, complications, and overall expenses related to these procedures. It involves patients with conditions like nonfunctioning kidney and localized renal tumors suitable for nephrectomy. Participants will be randomly assigned to one of two groups undergoing either laparoscopic or open nephrectomy. Both procedures aim to remove kidney tissue, with laparoscopic surgery being less invasive. The study measures post-operative recovery details including length of hospital stay, rehabilitation progress, and cost differences between the two surgical approaches. During the study, researchers will monitor hospital stay length for 30 days after surgery and assess clinical effectiveness within the same period. Participants will undergo post-operative evaluations to track recovery and any complications. The study includes follow-up visits and collects data on rehabilitation and healthcare costs, ensuring comprehensive monitoring of both surgical options over the month following surgery.
CONDITIONS
Brief Title
Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiology score 1-3
- Indication for simple total nephrectomy or hemi nephrectomy due to benign chronic inflammatory non-functioning kidney
- Indication for partial nephrectomy for localized renal mass 7 cm or smaller suitable for nephron-sparing surgery
- Indication for radical nephrectomy or radical nephroureterectomy with bladder cuff for localized renal tumor without major vascular invasion
- Patient must be fit for general anesthesia and surgery
- Patient must provide written informed consent
You will not qualify if you...
- Emergency surgery cases
- Dialysis-dependent patients
- Planned hybrid surgical procedures
- Patients with incomplete data
- Patients with metastatic disease at presentation
- Prior extensive ipsilateral retroperitoneal surgery or severe adhesions preventing laparoscopy
- Need for major concomitant procedures (e.g., large bowel resection) during surgery
- Locally advanced tumor with major vascular involvement requiring complex vascular reconstruction
- Uncorrected coagulopathy
- Pregnancy or obesity with body mass index over 40
- Inability to provide informed consent or comply with follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Hospital stay plus initial recovery period
Participants undergo either open or laparoscopic nephrectomy followed by immediate post-operative recovery.
1 surgical visit (in-person) and hospital stay
Duration - 30 days post-operative
Participants are monitored for clinical effectiveness and recovery for 30 days after surgery.
Follow-up visits during 30 days post-operative period
Trial Site Locations
Total: 1 location
1
Menoufia Faculty of Medicine
Shibīn al Kawm, Shebin Elkom, Egypt, 32111
Actively Recruiting
Research Team
H
Haitham Badr Elnaggar
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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