Actively Recruiting

Phase Not Applicable
Age: 40Years +
All Genders
ID06283004

The Effect of Aerobic Exercise Training in Different Slope Types on Exercise Capacity, Respiratory Functions, Muscle Strength, and Functional Status in COPD Patients

Led by Acibadem University · Updated on 2025-06-13

51

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

A

Acibadem University

Lead Sponsor

B

Bezmialem Vakif University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Chronic obstructive pulmonary disease (COPD) is a common condition with ongoing research due to its persistent nature and large affected population. This study aims to compare the effects of walking training on exercise capacity, lung function, muscle strength, and daily functioning in COPD patients using three different treadmill slopes: level, uphill, and downhill. The study seeks to understand how these different walking types may benefit patients by engaging various muscle groups differently. Participants will be randomly assigned to one of three groups: level walking, uphill walking, or downhill walking. Each group will complete an 8-week treadmill walking program, training twice a week. The treadmill slope will be fixed for each group at 0 degrees for level walking, +10 degrees for uphill walking, and 10 degrees for downhill walking, with a special apparatus used to provide the downhill slope. Training sessions will include warming up, walking at an individualized speed based on a baseline 6-minute walk test, and cooling down. Participants will be assessed at the start and end of the 8-week program. Measurements will include walking distance during a 6-minute walk test, detailed lung function tests, muscle strength tests for skeletal and respiratory muscles, a 30-second sit and stand test, and a functional performance questionnaire. Researchers will also monitor breathlessness, fatigue, and exertion levels during the study. The total participation time is 8 weeks, with evaluations to track changes in physical and respiratory function.

CONDITIONS

Brief Title

Investigation of Walking Training With Different Slope Types in COPD Patients

Who Can Participate

Age: 40Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with COPD in group A, B, or E according to GOLD assessment
  • Able to walk independently
  • No exercise contraindications
  • Mentally appropriate with a mini mental test score of 24 or higher
Not Eligible

You will not qualify if you...

  • COPD at GOLD stage 4 in spirometric evaluation
  • Presence of low oxygen levels (hypoxemia)
  • Participation in another pulmonary rehabilitation program within the last 6 months
  • COPD exacerbation within the last month
  • Additional respiratory diseases such as asthma or bronchiectasis
  • History of lung surgery
  • Orthopedic, neurological, or heart disease affecting exercise
  • Uncontrolled high blood pressure or diabetes
  • Presence of cancer

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 8 weeks

Participants undergo an 8-week treadmill walking training program twice weekly with assigned slopes of downhill, uphill, or level walking.

Two sessions per week for 8 weeks

Trial Site Locations

Total: 1 location

1

Bezmialem Vakif University, Department of Physiotherapy and Rehabilitation

Istanbul, Eyüp Sultan, Turkey (Türkiye)

Actively Recruiting

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Research Team

M

Meryem Bektaş Karakuş, Res Asst.

A

Alis Kostanoğlu, Assoc. Prof.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

3

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Published Research Related To This Trial

Lower limb joint work and joint work contribution during downhill and uphill walking at different inclinations.

Nathalie Alexander, Gerda Strutzenberger, Lisa Maria Ameshofer...

https://pubmed.ncbi.nlm.nih.gov/28734544

Downhill walking influence on physical condition and quality of life in patients with COPD: A randomized controlled trial.

Azar Moezy, Azadeh Erfani, Ali Mazaherinezhad...

https://pubmed.ncbi.nlm.nih.gov/30159300

Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease?

Carlos Augusto Camillo, Chris Burtin, Miek Hornikx...

https://pubmed.ncbi.nlm.nih.gov/25758676

Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial.

Carlos Augusto Camillo, Christian Robert Osadnik, Chris Burtin...

https://pubmed.ncbi.nlm.nih.gov/32444407