Study of Very Low-Calorie Ketogenic Diet Versus Very Low-Calorie Diet Before Bariatric Surgery to Preserve Muscle and Support Weight Loss

What this Trial Is About

Obesity rates have increased significantly worldwide, leading to serious health risks like type 2 diabetes, heart disease, and certain cancers. Bariatric surgery is considered the most effective treatment for severe obesity, improving long-term weight loss and related health issues. However, surgery can be technically challenging due to fat around the abdomen and liver size, so losing weight before surgery is often recommended to improve outcomes. This trial evaluates a very low-calorie ketogenic diet VLCKD compared to a very low-calorie diet VLCD before bariatric surgery to study their effects on body composition and metabolic rate. The study compares two dietary plans given for 14 days before surgery. One group follows a VLCD with meal sachets totaling under 800 kcal daily, including 50-60 grams of carbohydrates and 42-51 grams of protein, along with raw vegetables and clear soups. The other group follows a VLCKD consisting of six meal sachets daily with under 800 kcal, about 50 grams of carbohydrates, and 100 grams of protein, plus low-glycemic vegetables. Both diets aim to reduce fat mass while preserving lean body mass and resting metabolic rate. Participants will be monitored before surgery, on surgery day, and three months after surgery. Assessments include body composition changes, weight, physical activity, patient satisfaction, side effects, diet compliance, muscle strength, surgical outcomes, and extensive biochemical testing. Researchers will track changes in fat free mass relative to total body weight loss as the main outcome, along with other clinical and safety measures throughout the study period.

Ketogenic Diet Prior to Bariatric Surgery