Leptospirosis Care Bundle Study: A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating a treatment approach called the Leptospirosis Care Bundle for patients with Leptospirosis, a condition that can lead to complications like acute kidney injury. The study acknowledges the importance of finding effective management strategies for this illness. The Care Bundle has shown promise in reducing the risk of acute renal failure in affected patients. The treatment involves a step-by-step process including identifying suspected Leptospirosis cases, conducting investigations, administering antibiotics within one hour after blood cultures are taken, providing intravenous fluids, and managing acute kidney injury based on disease stage using KDIGO guidelines. Participants are randomly assigned to either receive this Care Bundle or no intervention as a control group. During the study, participants will be closely monitored for kidney function, with the primary outcome being the number of patients who experience reduced acute kidney injury within 72 hours. Hospitalized patients will be assessed through clinical signs and laboratory tests. The study is sponsored by Chulalongkorn University and participation involves regular evaluations during the hospital stay until the primary outcome is measured.

Leptospirosis Care Bundle Study