Study of Leucine Supplement Timing to Improve Muscle Growth in Older Men Aged 65 to 75

What this Trial Is About

Sarcopenia is the gradual loss of muscle mass and strength that occurs with aging, leading to increased frailty and health problems. This trial investigates how leucine, an essential amino acid known to boost muscle protein synthesis, can help older men improve muscle mass when taken at different times around meals. Researchers aim to find the best timing for leucine intake after exercise to maximize muscle growth in men aged 65 to 75 years. Participants will be randomly assigned to take leucine supplements either between mealsbetween breakfast and lunch, lunch and dinner, and dinner and supperor with meals, specifically with breakfast, lunch, and dinner. The study compares these two supplementation schedules over a 7-day period to assess muscle protein synthesis and related muscle signaling pathways. During the study, participants muscle protein synthesis will be measured to evaluate the response to leucine feeding. Researchers will also examine muscle anabolic and catabolic signaling. The study involves regular monitoring over 7 days, and participants must meet specific health criteria to join. The research is led by the University of Nottingham and includes men who are not engaged in regular resistance exercise and meet strict health and lifestyle requirements.

Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age