Secondary Prevention of Dementia in Memory Clinics: Implementation and (Cost-)Effectiveness of an Integrated Lifestyle Intervention

What this Trial Is About

Researchers are studying older adults aged 50 years and above who have subjective cognitive decline (SCD) or mild cognitive impairment (MCI) and are at risk for dementia. This multi-center randomized controlled trial called LIGHT aims to evaluate the impact and cost-effectiveness of a one-year lifestyle intervention on lifestyle changes and dementia risk reduction compared with general health advice. The study focuses on improving factors related to brain health and identifying how to best implement sustainable lifestyle changes in memory clinic patients. Participants are randomly assigned to one of two groups for 12 months. Group A receives a personalized lifestyle intervention that includes three individual coaching sessions with a trained lifestyle coach, a voucher program to promote brain-healthy activities, and access to an online self-management tool for dementia risk reduction. Group B receives general health advice and regular healthcare, including an informational folder about lifestyle and dementia risk reduction. Throughout the study, participants undergo various assessments including cognitive tests, measurements of body mass index, blood pressure, cholesterol, and blood sugar levels. Questionnaires cover lifestyle habits, health status, quality of life, physical activity, stress, sleep quality, social support, and knowledge of dementia risk factors. Researchers also collect data on healthcare use and costs. The primary outcome is the change in dementia risk profile measured by the Lifestyle for Brain Health (LIBRA) score after one year. Additional evaluations include interviews and questionnaires about the intervention's implementation and participant experiences.

Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial