Actively Recruiting
Healthy Futures Research Study: Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
Led by Case Comprehensive Cancer Center · Updated on 2026-03-16
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Case Comprehensive Cancer Center
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting this study to understand the biological impact of chemical exposure on residents near the February 3, 2023 train derailment in East Palestine, Ohio. The study aims to measure DNA damage and observe how biomarker changes relate to proximity to the derailment and participants' health histories and behaviors. It also seeks to explore residents' experiences and long-term health concerns following the event. Participants will complete a brief web-based survey about their experiences related to the derailment, health issues, and background health information. They may also provide biological samples such as blood, saliva, hair, or toenail clippings through mailed collection kits or in-person blood draws. Additionally, a group of 40 participants will be invited to take part in a 90-minute video and audio-recorded interview. During the study, participants will receive updates and information on future research opportunities. Researchers will assess somatic mutation rates over up to 24 months, examining geographic associations and self-reported symptoms. The study involves sample collection, surveys, interviews, and ongoing communication, with participation lasting up to two years.
CONDITIONS
Brief Title
Linking Somatic Mutation Rate With Baseline Exposure in East Palestine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Residence on February 3rd, 2023 in Columbiana County, Ohio, Mahoning County, Ohio, Beaver County, PA, or Lawrence County, PA.
- Current residence in the United States.
- Age 18 years or older.
You will not qualify if you...
- Address provided for February 3rd, 2023 not in Columbiana County, Ohio, Mahoning County, Ohio, Beaver County, PA, or Lawrence County, PA.
- Invalid address provided for February 3rd, 2023 residence.
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for eligibility screening and consent
Duration - One-time activity occurring shortly after enrollment
Participants complete a brief web-based survey about their experiences and health history related to the train derailment, and may provide biological specimens such as blood, saliva, hair, or toenail clippings using mailed kits or in-person collection.
1 survey and up to 2 sample collection interactions (mailed kits or in-person visits)
Duration - One-time 90-minute session occurring after baseline activities
A subset of participants will take part in a 90-minute video or audio-recorded interview to discuss their experiences, stressors, and health concerns following the derailment.
1 interview session (remote or in-person)
Duration - Up to 24 months
Participants will be followed for up to 24 months to assess somatic mutation rates and health outcomes related to chemical exposure from the derailment.
Periodic communications and possible follow-up assessments as part of ongoing study updates
Trial Site Locations
Total: 1 location
1
Case Western Reserve University, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
F
Fredrick R Schumacher, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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