Actively Recruiting
A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors
Led by Maastricht Radiation Oncology · Updated on 2026-01-27
50
Participants Needed
1
Research Sites
343 weeks
Total Duration
On this page
Sponsors
M
Maastricht Radiation Oncology
Lead Sponsor
M
Maastricht University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
There is a high medical need to improve treatment outcome for high-grade and low-grade glioma since no curative treatment is available. To achieve this goal, a broader understanding is needed of the causes of inter-and intratumoral heterogeneity; glioma dedifferentiation and invasion; the major determinants of malignancy and treatment failure in glioma patients. Patient-derived organoid (PDOs) of high-grade gliomas and low-grade gliomas will be used to identify the mechanisms that underlie this malignant behaviour and treatment resistance. This insight may be used to develop patient avatars to simultaneously test multiple new treatment modalities that are predictive for survival and quality of life of glioma patients.
CONDITIONS
Official Title
A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- MRI diagnosis of low grade glioma (LGG) or high grade glioma (HGG)
- Age 18 years or older
- Patient is eligible for a resection of the tumor
You will not qualify if you...
- Contra-indication for neurosurgical resection of the tumor
- Incapacitated patient, unable to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Maastricht Radiation Oncology
Maastricht, Limburg, Netherlands, 6229ET
Actively Recruiting
Research Team
A
Annika Noordink, Msc
CONTACT
C
Chantal Overhof
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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