Actively Recruiting
LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)
Led by University of California, Davis · Updated on 2023-10-31
100
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.
CONDITIONS
Official Title
LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of non-small cell cancer or small cell cancer confirmed by tissue or biochemical tests
- Signed and dated informed consent form provided
- Willingness to follow all study procedures and be available for study duration
- Age 18 years or older at consent
- Currently receiving systemic therapy and eligible to continue current treatment with no more than a 30-day planned break for local ablative therapy
- At least one prior line of systemic therapy for metastatic disease with at least 3 months of clinical benefit on the most recent therapy before new metastatic lesions developed
- No more than 5 progressing or new metastatic lesions
- All progressing or new metastatic lesions can be safely treated with local ablative therapies as determined by treating specialists
You will not qualify if you...
- Medical conditions that prevent use of local ablative therapies
- History of treatment-related side effects that limit or prevent local ablative therapies
- Presence of progressing brain (intracranial) lesions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, Davis
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
S
Selina Laqui
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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