Boussu

Researchers are evaluating treatments for newly diagnosed multiple myeloma in patients who cannot undergo autologous stem cell transplantation. This Phase 3 study compares two drug combinations belantamab mafodotin with lenalidomide and dexamethasone BRd versus daratumumab with lenalidomide and dexamethasone DRd. The goal is to see if BRd extends progression-free survival and improves minimal residual disease negative status compared to DRd. Participants receive either BRd or DRd treatment, continuing until disease progression, death, unacceptable side effects, withdrawal, or study end. Both treatment arms involve the administration of lenalidomide and dexamethasone alongside either belantamab mafodotin or daratumumab. Treatment duration may last up to approximately seven years. During the study, participants will undergo regular assessments including monitoring disease progression, response to treatment, and side effects. Measurements include progression-free survival, overall survival, and the number achieving minimal residual disease negative status. Quality of life questionnaires and blood tests will also be conducted. Safety monitoring includes eye exams and tracking adverse events throughout the study duration.

Researchers are studying the use of bempedoic acid combined with ezetimibe and either rosuvastatin or atorvastatin, known as triple therapy, in adults with primary hypercholesterolemia or mixed dyslipidemia. The study aims to evaluate the effectiveness and safety of this combination in real-world clinical practice, focusing on lowering LDL cholesterol LDL-C levels. This is an observational study, meaning no drugs are administered by the study team instead, existing treatments are monitored. Participants are adults who have started triple therapy within the past four weeks and are followed for up to one year. The study looks at LDL-C changes after 8 weeks and 1 year of treatment, adherence to the therapy, side effects, and cardiovascular events such as heart attacks and strokes. No new treatments are given instead, researchers collect information on the participants ongoing treatments involving bempedoic acid, ezetimibe, and either rosuvastatin or atorvastatin. During the study, participants LDL-C levels, laboratory values, and treatment adherence are regularly reviewed. Researchers will also record any adverse events and track major cardiovascular events over the year. The primary measurement is the change in LDL-C from before treatment to 8 weeks after starting triple therapy. Participants health is followed through routine clinical assessments, and the study lasts for up to one year after beginning triple therapy.

Researchers are evaluating standard neoadjuvant treatment options for patients aged 70 years or older with high-risk stage II and stage III rectal cancer in a multicentre, open-label, randomized clinical trial called SHAPERS. The study compares conventional neoadjuvant therapy with total neoadjuvant therapy TNT to understand their safety and effectiveness for this older patient group. Participants are randomly assigned to one of two groups. The conventional treatment group receives either short course radiotherapy followed by surgery or watch & wait, with optional adjuvant chemotherapy, or long course chemoradiotherapy followed by surgery or watch & wait, also with optional adjuvant chemotherapy. The TNT group receives one of several treatment regimens decided by the investigator before randomization, including combinations of short course radiotherapy, oxaliplatin-based chemotherapy lasting up to 18 weeks, and chemoradiotherapy, followed by surgery or watch & wait. During the study, participants undergo treatments as assigned and are monitored for outcomes including overall survival, progression-free survival, peripheral sensory neuropathy, and severe toxicities over 3 years after randomization. Researchers will gather information about treatment effects, side effects, and patient survival to compare the two approaches. The study includes follow-up assessments to track these outcomes and participant safety throughout the trial duration.

Researchers are evaluating a medicine called elranatamab in people with multiple myeloma MM, a type of cancer. This study compares elranatamab to other commonly used combination therapies for MM that has returned or not responded to previous treatments. Participants must be 18 years or older and have received prior treatments, including an anti-CD38 antibody and lenalidomide. The study is a phase 3, randomized trial sponsored by Pfizer. Participants will be randomly assigned to receive either elranatamab alone or one of several combination therapies chosen by the study doctor. Elranatamab is given as a shot under the skin at the study clinic about once a week, with possible adjustments later. The combination therapies include two to three medicines taken by mouth or given by injection or infusion at the clinic. Treatment continues until the multiple myeloma stops responding. During the study, participants attend regular visits to monitor their response and side effects. Follow-up continues after treatment ends through telephone contacts or visits. Researchers will measure outcomes such as progression-free survival, overall survival, response rates, duration of response, and quality of life over approximately five years. Safety monitoring includes tracking adverse events and laboratory results throughout and after treatment.

This research aims to explore how muscle thickness and subcutaneous tissue changes, measured by ultrasound, relate to fluid compartments assessed through bioelectrical impedance analysis BIA in critically ill patients in the intensive care unit ICU. Patients in the ICU often suffer from muscle loss and tissue swelling caused by inflammation, lack of movement, and fluid treatments. The study seeks to better understand these changes and their impact on muscle strength and recovery at ICU discharge. The study uses daily ultrasound and BIA measurements to monitor muscle thickness and fluid balance in ICU patients. Ultrasound will focus on muscles like the rectus femoris, tibialis anterior, and biceps brachii, while BIA will estimate body water and fluid compartments. Data collection will include clinical parameters, fluid balance, and body weight, all taken with patients positioned in a standardized way. At ICU discharge, muscle strength will be evaluated using the MRC-sum score and handgrip strength with a dynamometer. Participants will undergo daily assessments from ICU admission until discharge or up to 28 days, including ultrasound, BIA, fluid balance tracking, and clinical data monitoring. The study will analyze the relationship between fluid overload, muscle thickness changes, and edema, and how these factors affect muscle strength at discharge. This information aims to guide early rehabilitation and improve care strategies for critically ill patients.

Diffuse large B-cell lymphoma DLBCL is a fast-growing and uncommon cancer affecting certain immune cells, and it is the most common type of non-Hodgkin lymphoma. Follicular lymphoma FL is a slower-growing form of non-Hodgkin lymphoma. This research aims to evaluate how well the investigational drug epcoritamab works in adults with advanced DLBCL and FL in real-world medical settings. Participants will receive epcoritamab as prescribed by their doctors following local country guidelines. The study will include about 700 adults treated across roughly 80 sites in 12 to 20 countries. Treatment is given as subcutaneous injections, and the study observes participants over up to three years to gather effectiveness information. During the study, participants will continue their regular hospital or clinic visits as part of their usual care, without extra procedures or visits added by the trial. Researchers will monitor the percentage of participants who achieve an overall response to the treatment over approximately three years. The study is observational, meaning it follows patients receiving epcoritamab under normal clinical practice without altering their care.

Researchers are evaluating the clinical effectiveness and safety of teclistamab Tecvayli4, an anti-BCMACD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma. The study focuses on those who have received at least three previous treatments and are refractory to key therapies including proteasome inhibitors, immunomodulatory agents, and anti-CD38 monoclonal antibodies. This prospective observational study aims to monitor real-life outcomes in Belgium. Participants will receive teclistamab as part of their routine clinical care. The study follows patients monthly for the first six months of treatment, then every three months until the study ends or until events such as disease progression, withdrawal, death, or loss to follow-up occur. Data collection will continue for up to 24 months, or two years, to observe treatment effects over time. During the study, patients will have regular assessments including response evaluations based on standardized criteria, survival monitoring, adverse event tracking, and minimal residual disease assessments when applicable. Researchers will measure outcomes such as overall response rate, progression-free survival, overall survival, depth and duration of response, and time to next treatment. This ongoing monitoring is designed to understand how teclistamab performs in everyday clinical practice.