Al Azbakeya

This research aims to compare patient satisfaction between two types of digitally printed maxillary dentures for people who have lost all their upper teeth. The study focuses on whether dentures made from intra-oral digital scans provide better comfort, fit, appearance, and speech compared to those made from extra-oral digital scans. Eight participants with complete tooth loss and normal facial symmetry will be involved to help determine which scanning method leads to better patient-reported outcomes. Participants will receive both types of dentures: one created from direct intra-oral scans using a 3Shape scanner and the other from extra-oral scans of traditional impressions. Each denture will be worn for a period, separated by a two-week washout period without dentures to avoid carryover effects. The dentures are fabricated using 3D printing technology, ensuring precise and customized fit based on each scanning method. During the study, participants will complete satisfaction surveys after using each denture to report on comfort, fit, and aesthetic appeal. Researchers will analyze these responses to identify significant differences between the two methods. This evaluation occurs six months after wearing each denture, allowing ample time for adaptation. The goal is to guide clinicians on the preferred digital scanning approach to improve care for patients needing maxillary dentures.

Breast cancer is a common and deadly disease in women worldwide, characterized by several subtypes based on hormone receptor status. Researchers are investigating the role of epigenetic regulators, such as non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), and chromatin remodeling proteins in breast cancer development and progression. This study focuses on two specific lncRNAs, UPK1A-AS1 and UNC5B-AS1, which have not yet been studied in breast cancer patients, aiming to understand their diagnostic and prognostic potential as well as their interaction with chromatin modifying proteins and target miRNAs. The study will measure the expression levels of lncRNAs UPK1A-AS1 and UNC5B-AS1 and their target miRNAs in serum (liquid biopsy) and/or tissue samples from breast cancer patients using quantitative real-time PCR (qRT-PCR). Additionally, protein levels related to these ncRNAs will be quantified in serum and/or tissue samples by ELISA. The study will compare these molecular markers with classical tumor protein markers and correlate the findings with clinical and pathological characteristics of breast cancer, such as tumor stage, grade, receptor status, and other prognostic biomarkers. Participants will provide blood and tissue samples for analysis, and clinical data will be collected from medical records. Laboratory tests include RNA extraction, qRT-PCR, and ELISA for protein measurement. Researchers will analyze the relationships between ncRNA and protein expression and clinical features over about 12 months. The study also includes statistical analysis to assess the significance of findings, with the goal of identifying new markers that could improve breast cancer diagnosis and prognosis, and potentially serve as targets for gene therapy.

Researchers are studying early-stage breast cancer patients to evaluate the effects of memantine on preventing and improving paclitaxel-induced peripheral neuropathy (PIPN), a common and serious side effect of chemotherapy. PIPN can cause numbness, tingling, and painful sensations, often starting in the fingers and toes and progressing to the lower legs and wrists, significantly affecting daily activities and quality of life. This phase 2 trial addresses the lack of effective prevention for PIPN, noting memantine's potential neuroprotective and pain-reducing properties seen in other conditions. Participants will receive either memantine hydrochloride at a dose of 20 mg once daily or a matching placebo tablet for 12 weeks during their weekly paclitaxel treatment. The study compares these two treatments to assess memantine’s role in preventing or lessening the severity of PIPN symptoms. No other interventions or therapies are part of this trial. Participants will be monitored weekly for 12 weeks to track the occurrence and severity of paclitaxel-induced peripheral neuropathy. Researchers will assess symptoms such as numbness and pain, using clinical evaluations to measure how memantine affects these side effects. Safety and tolerability will also be observed throughout the study period.

Researchers are evaluating the effect of probiotic supplementation on weight gain caused by atypical antipsychotic medications in adult patients with schizophrenia. The study aims to improve quality of life and increase treatment compliance by reducing weight gain and assessing the impact of probiotics on patients' psychological state. This is a Phase 3 randomized controlled trial conducted at Ain Shams University Hospitals. Participants will receive probiotic supplementation using Lacteol fort 10 billion, containing Lactobacillus LS as the active ingredient. The intervention is designed to determine if probiotics can help decrease weight gained from antipsychotic medications over a 12-week period. The study compares this probiotic treatment with standard care in stable patients on second-generation antipsychotics who have already experienced significant weight gain. During the study, researchers will monitor weight changes and psychological status to assess the probiotic's effectiveness and impact. The primary outcome is the reduction of weight gain over 12 weeks. Participants must attend psychiatric clinics for assessments, and their progress will be tracked throughout the study duration to evaluate safety and treatment adherence.

This research aims to compare two treatments for hip labral tears: arthroscopic labral repair and arthroscopic labral debridement. It focuses on patients aged 18 to 60 years with femoroacetabular impingement or traumatic labral tears. The study evaluates hip function and pain over a one-year period following treatment. During the procedures, patients will undergo hip arthroscopy under general anesthesia while lying on their backs. Surgeons will use specific portals and fluoroscopy to access the hip joint and treat any labral, cartilage, or bone issues. Labral tears will be either repaired with suture anchors or debrided, depending on the assigned treatment group. Participants' hip function and pain levels will be assessed before surgery and at 1, 3, 6 months, and 1 year after surgery. Researchers will use several scoring methods including the Harris Hip Score, Visual Analogue Scale for pain, and the Hip Outcome Score for daily living and sports activities. These measures will help determine changes in hip function and pain over time.

Researchers are evaluating the use of honey as a natural topical skin disinfectant compared to the standard alcohol-based disinfectants. The study focuses on children aged 2 to 12 years with healthy skin, examining effectiveness and safety. It addresses concerns that alcohol and chlorhexidine may disrupt skin microbiota and contribute to antibiotic resistance, while honey has known therapeutic benefits such as antimicrobial and wound healing properties. The study involves two intervention groups: one where skin is sterilized using alcohol, and another using honey. Both treatments are applied topically to assess their disinfectant properties. The research aims to compare their ability to prevent infections during procedures that break the skin barrier. Participants will be monitored over three months to measure the effectiveness of honey as a disinfectant compared to alcohol. Researchers will assess safety, skin reactions, and the impact on skin microbiota. The study will also include regular evaluations to observe any adverse effects and document overall tolerability of the treatments.

Researchers are investigating the ability of two blood test ratios, the Neutrophil/Lymphocyte ratio (NLR) and the Lactate/Albumin ratio (L/A ratio), to predict outcomes in adults with sepsis and septic shock caused by lower respiratory tract infections (LRTI). LRTI includes conditions like pneumonia and bronchitis and often leads to ICU admission. Sepsis is a serious condition triggered by an overwhelming immune response to infection, potentially causing organ failure and death. Early detection and prognosis remain challenging despite current diagnostic criteria. This study focuses on patients admitted to the intensive care unit with confirmed sepsis according to established definitions. It compares the sensitivity and specificity of NLR and L/A ratio as markers for predicting mortality and disease progression in these patients. The study follows participants from randomization until death or discharge from the ICU over a period of 12 to 18 months, monitoring these ratios to assess their prognostic value. Participants will be closely observed during their ICU stay with regular blood tests measuring neutrophils, lymphocytes, lactate, and albumin levels. Researchers will track mortality rates and correlate these with the NLR and L/A ratio values. The study aims to identify which ratio best predicts patient outcomes, potentially aiding earlier and more accurate clinical decisions. Total participation may last up to 18 months, encompassing hospital stay and follow-up until death or discharge.

Researchers are comparing the use of a flexible and navigable suction ureteral access sheath (FANS) with a traditional access sheath during retrograde intrarenal surgery (RIRS) to treat kidney and ureter stones. The study focuses on improving stone removal, reducing complications like infection, and enhancing overall surgical outcomes. RIRS technology has advanced with tools like single-use flexible ureteroscopes and high-power lasers, but challenges remain in clearing residual stone fragments and managing pressure inside the kidney. The study compares two procedures: RIRS using the traditional ureteral access sheath and RIRS using the flexible and navigable suction ureteral access sheath (FANS). FANS can be guided into different parts of the kidney to better remove stone fragments by suction, potentially improving stone clearance and reducing infection risk. The traditional sheath helps reduce pressure and improve drainage but has limitations in reaching all kidney areas, which FANS aims to overcome. Participants will be monitored for stone clearance 12 weeks after surgery, with the main outcome being the stone-free rate. The study involves assessments of kidney stone size and location, urine tests, and monitoring for infections or complications. Safety, effectiveness of stone removal, and patient recovery will be evaluated throughout the study, which includes follow-up visits to measure outcomes and any adverse events.

The goal of this clinical trial is to learn if Chitosan mouthwash works to affect the recurrence of black stains in pediatric patients. The main questions it aims to answer are: Does Chitosan mouthwash lower the number of times participants need to do a scaling and polishing cleaning sessions more than normal? Does Chitosan mouthwash will decrease the recurrence of black stains in children and improve esthetics ? Participants will: Take chitosan every day for 4 months Visit the clinic once every 6 weeks for checkups and data collection

Researchers are evaluating a new multi-component score called the Readiness for EXtubation score (REXs) to predict when ICU patients on invasive mechanical ventilation are ready for extubation. Extubation readiness is determined through clinical criteria including improvement in underlying conditions, hemodynamic stability, and adequate respiratory effort. The study addresses the challenge of safely removing patients from mechanical ventilation by improving prediction of extubation success, defined as not needing invasive support within 48 hours after tube removal. The study involves screening ICU patients on invasive mechanical ventilation daily to collect various clinical data including ventilation parameters, blood gases, respiratory muscle strength, cough ability, sedation levels, heart rate, hemoglobin, and nutrition status. These data will be anonymously recorded in an electronic case report form. The REXs score will be developed and analyzed based on these parameters to predict extubation readiness. The target enrollment is about 470 patients to account for a 10% dropout rate. Participants will be monitored throughout the weaning process with assessments such as spontaneous breathing trials, arterial blood gas measurements, ventilator settings, and sedation scores. The primary outcome is extubation failure within 48 hours after extubation. Statistical analyses will evaluate associations between clinical variables and extubation outcomes, and the REXs score's predictive ability will be examined. Data collection, monitoring, and safety evaluations will occur during patients' ICU stay until hospital discharge or death.