Al Azbakeya

Researchers are investigating patient satisfaction with two types of digitally printed maxillary dentures in patients who have no natural teeth completely edentulous. This study compares dentures made from intra-oral digital scans taken directly inside the mouth versus those made from extra-oral digital scans created from traditional impressions taken outside the mouth. The goal is to understand if one scanning method leads to better comfort, fit, aesthetics, and overall satisfaction for patients. Participants will receive both types of dentures fabricated using 3D printing technology. The intra-oral scanning uses a 3Shape scanner to capture digital impressions directly from the mouth, while the extra-oral scanning involves taking traditional impressions that are then scanned externally. Each participant will wear one type of denture for a period, followed by a two-week wash-out period without dentures, before switching to the other type. After wearing each denture, participants will complete satisfaction surveys. During the study, participants will be assessed for comfort, fit, and aesthetics of each denture type using structured questionnaires. Satisfaction will be measured after six months of wearing each denture, with the two-week wash-out period separating interventions. Data from these assessments will be analyzed to identify any significant differences in patient preferences. The study duration includes these treatment and evaluation phases and aims to provide evidence to guide clinical choices for denture fabrication.

Breast cancer is a leading cause of death among women worldwide and is classified into subtypes based on hormone receptor and HER2 status. This research focuses on the role of epigenetic regulators, specifically non-coding RNAs like lncRNAs UPK1A-AS1 and UNC5B-AS1, which may influence gene expression involved in breast cancer development. Studying these molecular markers aims to improve diagnosis and prognosis and enhance understanding of breast cancer biology. The study is observational and involves Egyptian female breast cancer patients newly diagnosed with malignant non-metastatic breast cancer, compared to healthy volunteers. Researchers will measure the expression levels of the candidate lncRNAs and their target microRNAs using quantitative real-time PCR in serum and tissue samples. Protein levels related to these markers will be assessed by ELISA. The study will also analyze the relationship between these markers and clinical features such as tumor stage, grade, and known prognostic biomarkers. Participants will provide blood and tissue samples for molecular analysis, and clinical data will be collected from medical records. Laboratory tests include RNA extraction, qRT-PCR, and ELISA assays. The primary outcomes include evaluating the expression and role of the lncRNAs and their targets, comparing them between patients and healthy controls, and correlating these findings with clinical characteristics. The study will last about 12 months, with careful data analysis to explore potential new markers for breast cancer diagnosis and prognosis.

Cancer is a major cause of illness and death worldwide, and chemotherapy drugs, while effective against cancer cells, often cause side effects. One serious side effect is chemotherapy-induced peripheral neuropathy CIPN, which can be severe and affect daily activities and quality of life. This trial focuses on paclitaxel-induced peripheral neuropathy PIPN, which includes symptoms like numbness and pain that start in fingers and toes and may progress upwards. Memantine, a drug used for Alzheimers disease, has shown potential to reduce chronic pain and neuroinflammation and is being studied here for its effects on PIPN. The study is a phase 2, randomized, triple-blind trial comparing memantine hydrochloride 20 mg once daily with a placebo, alongside weekly paclitaxel chemotherapy 80 mgm2 for 12 weeks in female breast cancer patients. Forty patients will receive memantine plus paclitaxel, and another forty will receive placebo plus paclitaxel. The aim is to evaluate memantines ability to prevent or reduce paclitaxel-induced peripheral neuropathy. Participants will be monitored weekly for 12 weeks to assess the incidence and severity of neuropathy and pain. Quality of life and depressive symptoms will be evaluated at the start, 6 weeks, and 12 weeks. Blood samples will be collected to measure nerve growth factor levels at baseline and study end. Safety monitoring includes observing adverse reactions and patient well-being throughout the study period, which lasts 12 weeks. The trial is sponsored by Ain Shams University and excludes patients with certain medical conditions or medications.

The trial investigates the treatment of postinduction hypotension, a common complication during emergency abdominal surgery caused by factors like sepsis and low blood volume. This condition can lead to serious organ damage, so preventing and managing it quickly is important. The study compares two doses of norepinephrine bolus5 mcg and 10 mcgto find the best approach for treating low blood pressure in this setting. Participants will be randomly assigned to receive either a 5 mcg or 10 mcg norepinephrine bolus if their mean arterial pressure drops below 65 mmHg during surgery. The drug is prepared by diluting norepinephrine to a concentration of 10 mcgmL, then further diluted for dosing. If blood pressure does not improve within 2 minutes, the bolus may be repeated up to three times, followed by an infusion if needed. Fluid status will be assessed using leg raising maneuvers and fluid boluses before surgery, and heart rate and blood pressure will be monitored every 2 minutes for 30 minutes after skin incision. During the study, participants will undergo close blood pressure and heart rate monitoring at specified intervals. Researchers will measure the success of managing hypotension from anesthesia induction until 30 minutes after surgery begins. They will also assess the time and extent of low blood pressure, episodes of slow heart rate, and high blood pressure. The entire participation period covers the time from anesthesia induction to 30 minutes post-incision, focusing on immediate treatment response and safety under surgical conditions.

Researchers are evaluating the effects of probiotic supplementation on weight gain caused by atypical antipsychotic medications in adult patients attending psychiatric clinics. The study aims to improve the quality of life by reducing weight gain and increasing treatment compliance among patients taking these medications. It also examines the impact of probiotics on patients psychological state. Participants will be randomly assigned to receive either a probiotic supplement called Lacteol fort 10 billion, which contains lactobacillus LS and a culture medium, or no additional intervention while continuing their standard antipsychotic treatment. The study will last 12 weeks, focusing on changes in weight and psychological assessments. During the study, patients weight and psychological status will be monitored regularly. Researchers will assess the effectiveness of probiotics in decreasing weight gain associated with antipsychotic use. The main outcome will be measured after 12 weeks of treatment. Participants will be followed to ensure adherence and safety throughout the trial period.

Researchers are evaluating the use of honey as a topical skin antiseptic compared to alcohol in children aged 2 to 12 years with healthy skin. The study aims to explore honeys potential benefits as a natural product with antimicrobial, antioxidant, immune-modulator, wound healing, and synbiotic effects, especially given concerns about alcohols impact on skin microbiota and antibiotic resistance. Participants will be randomly assigned to one of two groups one receiving 70% isopropyl alcohol and the other receiving honey applied to a 3 cm by 3 cm area on the dorsum of the hand. Skin swabs will be collected from the area before and 20 seconds after the application to assess the disinfectant effect. The study uses a double-blind design to compare the effectiveness and safety of honey versus alcohol. During the study, children will undergo skin swabbing for microbiological analysis. Researchers will assess the efficacy of honey as a disinfectant in comparison to alcohol over a 3-month period. Safety and tolerability will be monitored, and participants skin condition will be observed. The total participation time aligns with the primary outcome measurement period of three months.

This research aims to evaluate and compare the ability of two blood test ratios, the NeutrophilLymphocyte ratio NLR and the LactateAlbumin ratio LA ratio, to predict outcomes in patients with sepsis and septic shock caused by lower respiratory tract infections. Sepsis is a serious condition where the bodys response to infection causes organ dysfunction and can be life-threatening, especially in intensive care settings. The study focuses on understanding which ratio better predicts patient prognosis and mortality. Participants admitted to the intensive care unit with sepsis related to lower respiratory infections will undergo clinical assessments and laboratory tests. Data collected include demographics, vital signs, medication use, mental status, and organ function scores. Blood tests will measure neutrophils, lymphocytes, serum albumin, lactate, and other markers. Various body fluid cultures will be taken to identify infection sources. All tests are performed at a central lab. During the study, researchers will track patient outcomes such as mortality, length of ICU stay, use of vasoactive medications, and support therapies like mechanical ventilation or renal replacement. The main outcomes are mortality and the prognostic value of the two blood test ratios measured from ICU admission until discharge or death. The study will last 12 to 18 months, with careful monitoring to understand how these ratios relate to patient survival and recovery.

Researchers are comparing the use of a Flexible and Navigable Suction Ureteral Access Sheath FANS with a traditional ureteral access sheath during retrograde intrarenal surgery RIRS for kidney and ureter stones. This randomized controlled trial aims to evaluate which method better aids in stone clearance while minimizing complications related to intrarenal pressure and residual stone fragments. The study addresses ongoing challenges in RIRS, such as managing intrarenal pressure and improving stone-free rates through technological advancements in access sheath design. The study involves two groups one using FANS and the other using a traditional ureteral access sheath UAS. After anesthesia, patients are positioned for surgery and their ureters are dilated. In the FANS group, a flexible suction sheath is navigated into the kidney to aspirate stone fragments during laser lithotripsy, while the traditional UAS group uses a fixed sheath positioned below the ureteropelvic junction. Both groups undergo laser treatment with irrigation pumps, and JJ stents are placed after the procedure. Participants will be monitored for stone clearance using imaging 12 weeks after surgery to measure the stone-free rate. The trial includes assessments of surgical effectiveness and potential complications related to ureteral access and stone removal. Patient health, urine infection status, and renal function are evaluated for eligibility, and the total duration of participation involves preoperative preparation, surgery, and follow-up assessments over several weeks.

Researchers are evaluating the safety and effectiveness of two sedation combinations, ketamine-propofol and dexmedetomidine-propofol, in children aged 2 to 12 undergoing cardiac catheterization to close simple left-to-right heart shunts. This phase 1 clinical trial focuses on pediatric patients having elective transcatheter device closure procedures for defects such as atrial septal defect, ventricular septal defect, or patent ductus arteriosus. Participants will be randomly assigned to receive one of two sedation regimens during their procedure. One group will receive an initial IV bolus of ketamine followed by a propofol infusion, while the other group will receive a dexmedetomidine loading dose and propofol infusion. Both treatments allow additional propofol doses if sedation is inadequate. The study monitors sedation during the procedure guided by echocardiography. Throughout the trial, children will be closely monitored for respiratory complications, heart rate, blood pressure, sedation quality, and recovery time within two hours after sedation. Safety and sedation levels will be assessed continuously to compare the two sedation methods. Participation involves the procedure and related assessments, with follow-up monitoring conducted during and shortly after the intervention.

Researchers are evaluating whether Chitosan mouthwash can reduce the recurrence of black stains on teeth in children aged 6 to 12 years. The study aims to find out if using Chitosan mouthwash daily lowers the need for professional cleaning sessions and improves the appearance of teeth by decreasing black stain recurrence. This clinical trial is sponsored by Al-Azhar University and focuses on pediatric patients with black stains on their teeth. Participants will first undergo scaling and polishing dental cleaning, followed by a 3-month observation period. After this, scaling and polishing will be repeated, and the children will use Chitosan mouthwash daily for an additional 3 months. The study uses a crossover design where each participant serves as their own control before and after using the mouthwash. During the study, participants will visit the clinic every 6 weeks for checkups and data collection over a total of 36 weeks. Researchers will measure the recurrence of black stains as the primary outcome. The study will monitor participant adherence to the mouthwash and assess teeth appearance and stain recurrence during these visits to evaluate the mouthwashs effects.