El Omraniya

Researchers are evaluating the potential benefits of adding dapagliflozin, a sodium glucose cotransporter type 2 inhibitor originally used for diabetes, to the standard care regimen for adults with liver cirrhosis and ascites. The study aims to see if dapagliflozin can reduce the need for large volume paracentesis, decrease ICU admissions, improve quality of life, save healthcare costs, and lower mortality rates in these patients. Participants will be randomly assigned to one of two groups. Group A will receive standard care, which includes dietary sodium restriction, treatment with diuretics a combination of loop diuretics such as furosemide or torsemide and a distal-acting diuretic spironolactone, and large volume paracentesis as needed. Group B will receive dapagliflozin in addition to the standard care, with dosing based on their Child Pugh score 10 mgday for scores A and B, and 5 mgday for score C. Patients will be advised to stay hydrated and avoid alcohol throughout the treatment. During the study, participants will be monitored for adherence, body weight, symptoms of urinary tract infection, and sodium levels at 1 and 2 weeks after starting therapy and at the end of follow-up. Quality of life will be assessed at baseline and at the end using a questionnaire specific for chronic liver disease. The main outcome measured is the number of times paracentesis is needed over three months, along with monitoring the incidence of cirrhosis complications. The study runs from July 2026 to September 2027.

This research aims to evaluate knee joint position sense, pain, and dynamic balance in females with primary dysmenorrhea, a common menstrual condition affecting many adolescent girls and women of reproductive age. The study is observational and focuses on young adult females aged 18 to 25 years. It addresses a gap in understanding how primary dysmenorrhea impacts physical therapy-relevant factors such as knee joint function and balance. Participants will be grouped based on their dysmenorrhea severity those with no or mild symptoms and those with moderate to severe symptoms. There is no intervention applied during the study instead, measurements are taken to compare these groups. The study observes participants during their menstrual cycle at specific times to assess balance and knee joint sense. During the study, researchers will measure overall stability indexes including antero-posterior and medio-lateral stability, as well as knee joint position sense and pain on the first and fourth days of menstruation. These assessments will help understand the effects of primary dysmenorrhea on physical balance and knee function. The total study duration includes these menstrual cycle assessments, with no additional intervention or treatment.

Researchers are evaluating how high frequency repetitive transcranial magnetic stimulation rTMS may improve postural instability, a disabling symptom in Parkinsons disease PD that leads to frequent falls and loss of independence. This study focuses on patients aged 55 to 70 years with mild to moderate PD, aiming to assess the long-term effects of this treatment on balance and stability. Participants will be randomly assigned to one of two groups one receiving a designed physical therapy program including aerobic exercise, stretching, proprioceptive neuromuscular facilitation techniques, active exercises, gait training, and weight shifting exercises three times a week for four weeks the other receiving the same physical therapy plus 12 sessions of high frequency rTMS over the primary motor cortex also three times a week for four weeks. The rTMS sessions last 20 to 30 minutes and are delivered using a specialized device. During the study, researchers will measure balance using the Biodex balance system before treatment, immediately after, and at one-month follow-up. They will assess stability indices including overall, anteroposterior, and mediolateral balance, as well as directional control and time to complete balance tests. The study lasts for six months, with ongoing monitoring to evaluate the lasting effects of the interventions on postural stability.

Researchers are evaluating the safety and effectiveness of ACE Reno, an oral transmucosal solution containing standardized bioactive peptides and amino acids, in patients with nephropathy caused by various conditions like diabetes, hypertension, autoimmune diseases, and chronic kidney disease CKD stages 1 to 5. The trial aims to determine if 12 weeks of ACE Reno treatment can reduce albuminuria or proteinuria and stabilize kidney function in these patients. Nephropathy is a significant global health issue affecting millions and leading to high socioeconomic costs worldwide. Participants will receive ACE Reno as a sublingual solution at a dose of 1 mL four times daily for 12 weeks. The solution contains peptide components designed to target pathways involved in kidney damage, including antifibrotic and vasodilatory mechanisms. This is an open-label, single-arm study with assessments at screening, baseline, weeks 4, 8, and 12, followed by a safety follow-up call at week 16. During the study, participants will undergo clinical evaluations including blood pressure, vital signs, weight, and laboratory tests such as creatinine, estimated glomerular filtration rate eGFR, electrolytes, liver panel, complete blood count, and urine albumin-to-creatinine ratio ACR. Patient-reported outcomes on fatigue and quality of life will also be collected. The primary outcome is the change in urinary ACR after 12 weeks. Safety and tolerability will be monitored throughout treatment and during the 4-week post-treatment follow-up period.

Researchers are investigating whether adding aerobic exercise to Cognitive Behavioural Treatment can improve outcomes for men who experience heavy drinking, impotence, and metabolic syndrome. This study aims to evaluate the benefits of combining these approaches, as the effect of adding aerobic training to this treatment has not been tested before. The trial involves adult men between 35 and 45 years old who have these conditions. The study divides participants into two groups of twenty men each. Both groups receive Cognitive Behavioural Treatment three times a week for 12 weeks, with each session lasting 30 minutes. The first group also takes part in supervised aerobic training by walking on an electrical treadmill for 50 minutes per session, three times a week during the same 12-week period. This comparison will help assess the added value of aerobic exercise alongside behavioural therapy. During the study, researchers will measure erectile function using the International Index of Erectile Function after 12 weeks. They will also evaluate body measurements like body mass index and waist circumference, blood pressure, blood markers including triglycerides and glucose, as well as psychological factors such as alcohol abstinence self-efficacy, mood, cravings, and stress levels. These assessments will monitor progress and treatment effects, with participation lasting the full 12 weeks of therapy.

Stroke is a significant health issue in the Egyptian population, with a noticeable rise in prevalence across all regions. Many stroke survivors experience disabilities that limit their physical activity, and their cardio-respiratory fitness is often negatively affected, increasing the risk of other heart-related diseases. This study aims to assess how aerobic training impacts cardiovascular endurance in stroke survivors to help speed up recovery and reduce risks of cardiac dysfunction and recurrent strokes. The study involves eighty post-stroke patients aged 55 to 65 who have hemiplegia or hemiparesis and functional ambulatory category above three. Participants will be randomly assigned to two groups one group will receive an aerobic training program combined with traditional physical therapy, while the other group will receive only the traditional physical therapy program. The aerobic training involves interval moderate exercise sessions three times a week for 16 weeks, lasting 30 to 40 minutes with warm-up and cool-down periods, at 50-80% of maximal heart rate adjusted monthly. The physical therapy includes neurorehabilitation exercises focusing on weight shifting, shoulder movements, knee extension, sensory reeducation, and body awareness. During the 16-week study, participants will undergo assessments including the 6-Minutes Walk Test and the Stroke Impact Scale at the start and end of the trial. These will evaluate cardiorespiratory fitness, walking endurance, and health-related quality of life. The study uses a quadruple-masked randomized design to ensure unbiased results. Participants adherence and safety will be monitored throughout, with follow-up evaluations after completing the intervention period.

Researchers are studying whether a gluten-free, low-histamine anti-inflammatory diet, with or without added physical therapy, can help children aged 6 to 17 with mild to moderate plaque psoriasis. The study aims to see if these interventions improve skin condition and reduce inflammation. It is a controlled trial with three groups to compare usual care, diet alone, and diet plus exercise over 12 weeks. Participants are randomly assigned to one of three groups continuing standard skin care, following the special diet, or following the diet plus attending supervised physical therapy sessions three times a week. The diet eliminates gluten and high-histamine foods and encourages fruits, vegetables, and healthy fish. The physical therapy includes light aerobic exercise, stretching, and relaxation activities led by a pediatric therapist. Children will have clinic visits at the start, mid-point 6 weeks, and end 12 weeks of the treatment period to assess progress. Researchers will measure psoriasis severity, inflammation markers, quality of life, exercise capacity, body mass index, dietary adherence, and physical therapy attendance. The total participation time is 14 weeks including screening. Safety and treatment effects will be carefully monitored throughout.

Researchers are studying children with acyanotic congenital heart disease undergoing elective repair of a congenital heart defect to evaluate the use of an antihistamine for preventing hypotensive transfusion reactions after blood-primed cardiopulmonary bypass CPB. This randomized, double-blinded, placebo-controlled Phase 4 study aims to compare the effects of combined chlorpheniramine versus a placebo in this pediatric population. Participants will be randomly assigned to one of two groups one group will receive a single intravenous dose of chlorpheniramine at 0.25 mgkg in 2 ml, and the other group will receive an equal volume of normal saline as a placebo. This dose is administered immediately after separation from CPB and before protamine administration. The study includes 40 children aged 1 to 7 years. During the study, researchers will monitor for episodes of hypotension within 15 minutes after weaning from cardiopulmonary bypass. Children will be closely observed during the procedure, and their response to the treatment will be assessed. The study will continue until December 2026, with safety and outcome measures collected during and after the procedure to evaluate the incidence of hypotensive transfusion reactions.

Researchers are evaluating the accuracy of an Artificial Intelligence AI-based automatic design system for fixed dental prostheses FDP compared to conventional computer-aided design CAD software. This in vitro study focuses on digital scans of adults with damaged teeth needing FDP, aiming to determine if AI-generated designs match the accuracy of human-designed restorations. The study will assess design precision and margin detection performance using advanced 3D analysis methods. The study includes two groups one where experienced dental professionals manually design prostheses using conventional CAD software based on patient-specific scans and occlusal anatomy, and another where an AI system automatically generates prosthesis designs. The AI workflow involves training, validation, and testing phases using real scan datasets and historical designs. Both types of designs will be compared for accuracy using 3D superimposition and Intersection over Union IoU percentage analysis. Participants digital intraoral scans will be collected and analyzed immediately after prosthesis design generation. Researchers will measure the design accuracy and margin detection using metrics such as F1 score, precision, and recall. Statistical analysis will evaluate differences between AI and human designs. The study period starts in June 2025 and will continue until June 2026, involving a total sample size of 438 scans for comprehensive assessment.

Researchers are investigating how different grades of chondromalacia, a common knee condition causing cartilage damage around the kneecap, affect both static and dynamic balance. This study aims to understand how worsening cartilage damage influences postural control, which is crucial for everyday activities like walking and maintaining stability. The study will include 100 participants, including those with varying severity of chondromalacia and healthy individuals as controls. Participants will be divided into five groups one control group of healthy individuals and four experimental groups with grades I through IV chondromalacia, each group containing 20 participants. The severity ranges from softening and swelling of cartilage to full erosion reaching the bone. Balance will be assessed using the Biodex Balance System to evaluate how each grade impacts the ability to maintain static and dynamic balance. During the study, participants will undergo balance measurements over a period of up to four weeks. Researchers will assess their static and dynamic balance through specialized tests, recording the bodys ability to maintain stability during various activities. The study will monitor participants with confirmed diagnoses by MRI and assess related factors such as knee pain and chronicity. This observational study seeks to provide detailed insights into balance impairments linked to chondromalacia severity.