Qasr El Nil

The trial investigates the use of zygomatic implants to treat patients with severely atrophic upper jaws who cannot receive standard implants due to insufficient bone. The study compares two methods of soft tissue augmentationbuccal fat pad graft and palatal rotation scarf graftto find which better improves tissue volume, stability, and prevents soft tissue complications around these implants. This research aims to enhance long-term outcomes and reduce complications in challenging oral rehabilitation cases. Participants will receive zygomatic implants placed using the Exteriorized ZAGA approach, either alone or combined with axial implants when bone allows. They will be randomly assigned to receive one of two soft tissue grafts after implant placement the buccal fat pad graft, known for its stem cell properties and tissue engineering potential, or the palatal rotation scarf graft, which uses well-vascularized palatal tissue to protect mucosal tissues and provide lasting stability and esthetics. During the six-month follow-up, participants will undergo assessments of soft tissue condition and quality around the implants, focusing on peri-implant soft-tissue recessions. Implant survival rates will also be monitored. The study includes regular clinical evaluations to track healing, tissue volume, and implant success, with the total participation lasting at least six months after treatment.

Researchers are comparing two types of platelet-rich fibrin materialsAlbumin Platelet Rich-Fibrin Alb-PRF and Platelet-rich fibrin PRFto a gelatin sponge to see how they affect recovery after free gingival graft harvesting from the palate. This randomized controlled trial involves adult patients undergoing this dental procedure to assess postoperative pain and healing outcomes. Participants will be randomly assigned to one of three groups Alb-PRF, PRF, or a control group using a gelatin sponge. Each participant will have 10 ml of blood drawn to prepare the Alb-PRF or PRF membranes, which will be applied to the donor site and secured with sutures. The control group will receive a gelatin sponge at the donor site. All surgeries are done under sterile conditions with local anesthesia, followed by a standardized postoperative care including ibuprofen, mouthwash, dietary advice, and oral hygiene instructions. Participants will be followed for 28 days with visits on days 3, 7, 14, 21, and 28 after surgery. Pain levels will be recorded using a Visual Analog Scale VAS at specified intervals. Researchers will also monitor wound healing, tissue color match, re-epithelialization, and clinical wound area. Sutures will be removed after 7 days and patients will be advised on pain management and oral care while reporting any unusual symptoms for early intervention.

Researchers are conducting a study to translate, culturally adapt, validate, and test the reliability of the Neuro Qol questionnaire in Arabic for diabetic patients with peripheral neuropathy and diabetic foot ulcers. This cross-cultural validation aims to produce a version suitable for use in Arabic-speaking countries, as no Arabic version currently exists. The study focuses on assessing quality of life related to neuropathy and foot ulcers among Arabic-speaking diabetic patients. The study involves translating the Neuro Qol questionnaire through a careful process including forward and backward translation, expert panel review, and harmonization. Participants include 290 diabetic patients aged 18 to 70 years who can read and write Arabic. They will complete the Arabic Neuro Qol as well as the Michigan Diabetic Neuropathy Scale MDNS in Arabic. The study includes two clinic visits spaced 7 to 14 days apart, with clinical examinations and data collection performed by trained staff. Participants will be initially screened and consented during the first visit, where demographic and clinical data will be collected. At the second visit, patients will complete additional questionnaires and report symptoms. Researchers will measure the cross-cultural validity, reliability, and adaptation of the Arabic Neuro Qol over an average of six months. The study will also monitor for diabetic neuropathy symptoms and related complications to ensure comprehensive assessment.

This research aims to evaluate how low-volume versus high-volume high-intensity interval training affects functional capacity and quality of life in patients with chronic heart failure. The study focuses on patients with reduced ejection fraction and seeks to compare the impact of different exercise volumes combined with standard medical treatment. Participants will be randomly assigned to one of three groups for an 8-week period one group will receive low-volume high-intensity interval training on a treadmill twice weekly along with usual care another group will perform high-volume high-intensity interval training twice weekly with usual care the third group will continue with standard medical treatment only. Both exercise programs vary in session duration and interval length. Throughout the study, participants will undergo assessments including a 6-minute walk test and 2D echocardiography at the beginning and end of the 8 weeks. Quality of life will be measured using the Minnesota Living with Heart Failure Questionnaire. The study monitors these outcomes to understand how exercise volume influences heart function and patient well-being during treatment.

Researchers are evaluating the accuracy of Ashley Howes analysis to predict whether orthodontic patients with permanent teeth will need tooth extraction as part of their treatment. This study focuses on patients with dental crowding and aims to understand if this cast analysis method can help in treatment planning decisions. The study uses Ashley Howes Analysis, which compares the width of the basal bone with the total tooth material using digital models. It is an observational study that involves analyzing maxillary dental models of patients with malocclusion to assess the correlation between tooth size and bone size. Participants will have their digital dental models assessed using the analysis method to measure the basal bone width versus the total tooth material. The primary outcome is the value obtained from Ashley Howes analysis at baseline. The study is sponsored by Cairo University and will last from February 2026 to February 2027.