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Researchers are studying the effects of digital health integration combined with neuromodulation therapies on sensory and motor function in patients aged 55 to 65 years who have diabetic neuropathy. The trial involves 60 male and female participants with type II diabetes and peripheral neuropathy, all receiving standard medical treatment. Participants are randomly assigned to two groups to evaluate the impact of these therapies on nerve and muscle function. One group of 30 patients will receive active Transcutaneous Electrical Nerve Stimulation (TENS) and Neuromuscular Electrical Stimulation (NMES) for 30 minutes, three times a week, over 10 weeks along with their medical treatment. The other group of 30 patients will receive placebo TENS and NMES sessions of the same duration and frequency, also alongside standard medical care. This setup allows comparison between real and placebo neuromodulation effects on diabetic neuropathy. Throughout the 10-week study, participants will undergo assessments of nerve conduction velocity and electromyography to measure changes in nerve and muscle function. Researchers will monitor patients' sensory and motor abilities to determine the therapies' influence. The study focuses on adherence to treatment schedules, safety, and the effectiveness of integrated digital health and neuromodulation approaches over the study period.

This trial investigates the effect of the Breather device on breathing and blood vessel function in male patients aged 55 to 60 with chronic obstructive pulmonary disease (COPD) and intermittent claudication caused by peripheral arterial disease (PAD). Research shows that COPD patients are at risk of developing PAD, which causes leg pain during walking. The Breather is an inspiratory muscle trainer that may improve breathing muscle strength, reduce breathlessness, and enhance exercise tolerance in these patients. Participants will receive treatment with the Breather device, which provides light to medium resistance to strengthen breathing muscles and potentially decrease breathlessness. They will also continue their usual pharmacological treatments. The study focuses on evaluating how this device affects breathing and vascular function. During the study, participants will undergo tests including spirometry to measure lung function and Doppler ultrasound to assess blood vessel function after four weeks of using the Breather. Researchers will monitor these outcomes to understand the device's impact on breathing and circulation. The study includes 60 male patients who are clinically stable and meet specific criteria related to COPD severity, body weight, and symptoms of intermittent claudication.

Eustachian tube dysfunction is a distressing problem, especially in seniors, and standard drug treatments are often not effective. This research investigates whether Buteyko breathing, a complementary therapy, can help seniors with chronic obstructive Eustachian tube dysfunction. The study involves older adults aged 65 to 75 years with this condition lasting more than three months and affecting one ear. Forty seniors will be randomly divided into two groups of 20 each. Both groups will receive usual care for two weeks, which includes a budesonide nasal spray at 64 micrograms once daily and a tablet taken twice daily containing 20 mg pseudoephedrine hydrochloride and 5 mg loratadine. In addition, one group will practice Buteyko breathing for 30 minutes twice daily for 14 weeks to evaluate its additional effect. Participants will be monitored during the treatment period, and the main outcome measured will be their Eustachian Tube Dysfunction Questionnaire score after two weeks. The study involves regular assessments to track the impact of these therapies on their condition and symptoms, aiming to understand whether adding Buteyko breathing improves their quality of life and ear function.

Obstructive sleep apnea negatively affects blood pressure, sleep quality, and breathing. This research involves 40 patients with mild to moderate obstructive sleep apnea, aiming to evaluate the effects of a specific respiratory exercise program over 12 weeks. Participants are divided equally into two groups to compare the outcomes of the exercise program against a control group. One group will perform shitali pranayama respiratory rehabilitation training involving six cycles of 5-minute breathing exercises, repeated three times daily (morning, afternoon, and evening) for 12 weeks. The other group will not receive this training and will serve as the control for comparison. Participants will be monitored over the 12 weeks, and researchers will assess changes in their apnea hypopnea index after the treatment period. The study focuses on non-obese adults aged 35 to 55 with mild to moderate obstructive sleep apnea. Safety and treatment effects will be observed throughout the study duration.

Researchers are investigating the effects of walking exercise with a dog on chronic subjective tinnitus complaints in patients who also have mild obstructive sleep apnea. This study includes adults aged 30 to 45 years who are obese and have both conditions. The trial aims to explore how physical activity, specifically walking with a dog, may help improve symptoms in this population, given that exercise is often recommended for these conditions and that dog walking may increase adherence to regular physical activity. Participants will be divided into two groups of 20 each, all following a low-calorie diet for 12 weeks. One group will also engage in free walking sessions with a dog for 30 minutes, three times per week, while the control group will follow the diet without the walking exercise. This design allows comparison of the effects of diet alone versus diet combined with walking exercise involving a dog. During the 12-week study period, participants will be monitored and assessed for changes in their tinnitus symptoms using the tinnitus handicap inventory. Researchers will evaluate the impact of the interventions after the 12 weeks to understand how walking exercise with a dog influences tinnitus complaints in people with mild obstructive sleep apnea. Safety and adherence to the protocol will also be observed throughout the study.

Researchers are evaluating the impact of electrical neuromuscular stimulation (NMES) on respiratory and leg muscles in patients with Chronic Obstructive Pulmonary Disease (COPD). The study aims to assess the effects of this intervention on pulmonary function and symptoms of leg restless syndrome. Participants include medically stable adults aged 45 to 55 years diagnosed with grade I or grade II COPD who meet specific clinical criteria for restless leg syndrome. The experimental group will receive active NMES using electrode patches placed over the intercostal respiratory muscles and leg muscles near the knees, targeting the quadriceps and intercostal muscles with specific pulse frequencies. This will be combined with a conventional pulmonary rehabilitation program that includes diaphragmatic and pursed lips breathing exercises. The control group will receive placebo NMES applied at the same locations alongside the same rehabilitation program. During the study, participants will be monitored and assessed over a 10-week period with the primary outcome measure being the dynamic gait index. Researchers will evaluate participants' pulmonary and leg muscle function, as well as monitor safety aspects like allergic reactions and other adverse effects. The study excludes individuals with certain medical conditions such as deep venous thrombosis, bleeding disorders, pacemakers, recent infected wounds, allergies to electrodes or tape, participation in other exercise programs, or loss of sensation or numbness.

Psychological problems caused by irritable bowel syndrome (IBS) can lead to sexual difficulties in men, such as weak erections or erectile dysfunction. This research is evaluating how elliptical exercise might improve symptoms of IBS and related sexual dysfunction in men aged 30 to 50. The study focuses on men with both IBS and erectile dysfunction, aiming to understand the impact of physical activity on these conditions. The study divides 40 men with IBS and sexual dysfunction into two groups of 20 each. Group I will engage in elliptical physical activity using an elliptical trainer for 40 minutes, three times per week, over a period of 12 weeks. Group II will not perform any physical activity during this time. The exercise is supervised and consistent to assess its effects. Participants will be monitored for changes in sexual function using the International Index of Erectile Function, assessed after 12 weeks. Researchers will track symptoms related to IBS and sexual health, evaluating the impact of the elliptical exercise compared to no exercise. The study focuses on safety and effectiveness of this behavioral intervention in improving sexual dysfunction related to IBS.

This research investigates whether adding exercise benefits diabetic men who experience erectile dysfunction and have low vitamin D levels. The study focuses on men with type 2 diabetes who report both conditions and aims to evaluate improvements in erectile function over 12 weeks. The trial compares the effects of vitamin D treatment alone versus vitamin D treatment combined with exercise. Participants will be divided into two groups of twenty men each. Both groups will receive pharmacological treatment with Cholecalciferol at a dose of 200,000 I.U. every two weeks for 12 weeks. In addition, one group will perform moderate-intensity treadmill walking for one hour, three times per week during the same 12-week period. Throughout the study, researchers will measure erectile function using the international index of erectile function after 12 weeks. Participants will be monitored for changes in symptoms related to erectile dysfunction and vitamin D levels. The total participation duration is 12 weeks, during which adherence to the medication and exercise regimen will be observed.

This research aims to evaluate the effects of honey intake combined with lifestyle changes on patients with non-alcoholic fatty liver disease who are also obese. The study includes 40 participants divided into two groups to compare the impact of adding honey to lifestyle modifications involving diet and exercise. The goal is to assess changes in cardiovascular risk factors and liver health during the trial. Participants in the first group will receive natural unprocessed honey orally at a total daily dose of 2 grams per kilogram of body weight, divided into three equal doses taken before meals. This group will also follow a low-calorie diet and participate in treadmill walking sessions lasting 40 minutes, three times a week, over 12 weeks. The second group will follow the same low-calorie diet and exercise routine without honey intake, for the same duration. Throughout the 12-week study, researchers will monitor participants' health by measuring high-density lipoprotein (HDL) levels as a primary outcome. Participants will be supported in maintaining their diet and exercise routines while being observed for changes in fatty liver condition and cardiovascular risk. The study focuses on adults aged 30 to 50 years with obesity and non-alcoholic fatty liver, aiming to better understand the additive role of honey in lifestyle interventions.

Researchers are studying obese males aged 35 to 45 who have both subjective tinnitus affecting both ears for at least 24 weeks and erectile dysfunction lasting at least 24 weeks. The study aims to understand how lifestyle changes might impact these conditions, focusing on sexual function and tinnitus symptoms. Participants will be divided into two groups of 20 males each. Both groups will follow a low-calorie diet for 12 weeks. One group will also participate in supervised aerobic treadmill walking sessions lasting 45 minutes, three times a week, during the same 12-week period. These interventions are behavioral and aim to assess the combined effect of diet and exercise compared to diet alone. During the study, researchers will assess sexual function using the international index of erectile function after 12 weeks. Participants will be monitored regularly throughout the intervention period. The study focuses on measuring changes in erectile function as the primary outcome to evaluate the impact of lifestyle modifications on sexual dysfunction and tinnitus in obese males.