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Researchers are investigating the added benefits of a physical activity program for older women who have subclinical hypothyroidism, glaucoma, and non-alcoholic fatty liver disease. This study aims to understand how exercise combined with usual thyroid hormone treatment may affect these conditions, particularly focusing on eye pressure and other health measures. The research involves elder females aged 65 to 75 years and is sponsored by Cairo University. Participants will be randomly assigned to one of two groups one group will receive their regular levothyroxine treatment along with a treadmill exercise program three times a week for six months. The second group will receive only the levothyroxine treatment without the exercise program. This comparison will help determine the effects of adding physical activity to the usual care. During the six-month study, participants will have various health assessments, including eye pressure measurement, body weight, waist size, blood pressure, blood tests for liver enzymes and lipids, thyroid hormone levels, and quality of life surveys related to glaucoma and physical and mental health. These evaluations will help researchers monitor changes and safety throughout the study period.

This research investigates the effects of adding hyperbaric oxygen therapy to a programmed physical activity regimen on musculoskeletal pain in elderly female breast cancer survivors who are taking aromatase inhibitors. These inhibitors, commonly prescribed for breast cancer survivors, often cause muscle and joint pain. The study aims to explore whether hyperbaric oxygen therapy can improve these symptoms alongside physical exercise. Participants are divided into two groups. Both groups follow a physical activity program consisting of aerobic treadmill training and strengthening exercises three times a week for two months. One group also receives additional hyperbaric oxygen therapy sessions lasting one hour, five times a week for two months. This comparison helps evaluate the added effect of hyperbaric therapy on pain relief. During the study, participants undergo assessments after two months using various measures of pain severity, interference, stiffness, function, and fatigue. Tools include the visual analogue scale, Western Ontario and McMaster Universities Osteoarthritis Index, Disabilities of the Arm, Shoulder and Hand questionnaire, fatigue severity scale, and Short Physical Performance Battery. The study monitors these outcomes to assess changes in pain and physical function over the treatment period.

Researchers are investigating the effects of a low-calorie diet on adults aged 40 to 55 who have Behcet Disease, obesity, and bilateral subjective tinnitus. The study aims to evaluate whether dietary restriction can help manage tinnitus symptoms associated with these conditions. This interventional trial is sponsored by Cairo University and uses a randomized, single-blind parallel design. Participants will be divided into two groups one group of 20 will follow a 12-week low-calorie diet regimen, while the other 20 participants will be on a waitlist without intervention. The study compares these two groups to assess the impact of diet restriction on tinnitus severity and related health factors over the 12-week period. During the study, participants will be assessed using several measures including the Tinnitus Handicap Inventory, visual analog scales for tinnitus severity and discomfort, and the Tinnitus Reaction Scale after 12 weeks. Additional evaluations include waist circumference, body mass index, anxiety and depression scales, life satisfaction, Behcet disease quality of life, and insomnia severity. These assessments help researchers understand the broader effects of the diet on participants health and quality of life.

Researchers are evaluating the effects of digital health combined with neuromodulation therapies on sensory and motor functions in patients with diabetic neuropathy. The study involves 60 male and female patients aged 55 to 65 years with type II diabetes and peripheral neuropathy. Participants are randomly assigned to two groups to assess the impact of these therapies alongside their medical treatment. One group of 30 patients will receive active transcutaneous electrical nerve stimulation TENS and neuromuscular electrical stimulation NMES for 30 minutes, three times a week, over 10 weeks, together with their standard medical care. The control group will receive placebo versions of these therapies following the same schedule and duration, also alongside medical treatment. During the study, participants will undergo several assessments including nerve conduction velocity and electromyography at 10 weeks. Additional monitoring involves digital tools such as the Google Fit app, Manage My Pain app, and the PEDIS Score Diabetes App to track symptoms and activity levels. The research team will monitor outcomes related to nerve function and patient-reported measures throughout the 10-week treatment period.

Researchers are evaluating the effect of the Breather device on breathing and blood vessel function in men aged 55 to 60 years with chronic obstructive pulmonary disease COPD and intermittent claudication, a symptom of peripheral arterial disease PAD causing leg pain during walking. The study focuses on how using this inspiratory muscle trainer might improve muscle strength, reduce breathlessness, and increase exercise tolerance in these patients. Participants are randomly assigned to one of two groups for 4 weeks, with sessions held three times per week. One group receives aerobic exercise on a treadmill for 20 minutes, Breather device training with light to medium resistance for 3 to 5 sets per session, and pursed lip breathing. The other group receives usual pharmacological treatment along with pursed lip breathing and treadmill exercise for 20 minutes. This design allows comparison between the Breather device plus exercise and standard care with exercise. Throughout the study, participants undergo assessments that include spirometry tests to measure lung function and Doppler ultrasound to evaluate blood vessel function, both after 4 weeks. Functional capacity is tested using a sit-to-stand test and treadmill exercise testing. Researchers will monitor participants respiratory and vascular responses to treatment. The total participation lasts for the 4-week treatment period, with detailed evaluation of breathing and vascular outcomes.

Researchers are studying seniors with chronic obstructive Eustachian tube dysfunction, a condition causing distress and often not well managed by drugs. This trial evaluates whether adding Buteyko breathing exercises to usual care can improve symptoms. The study is randomized, comparing the effects of usual care alone versus usual care plus Buteyko breathing therapy in older adults. Participants are divided into two groups of twenty seniors each. Both groups receive usual care, which includes a budesonide nasal spray 64 micrograms once daily and tablets containing 20 mg pseudoephedrine hydrochloride and 5 mg loratadine twice daily for 2 weeks. The experimental group also performs 30-minute Buteyko breathing exercises twice daily for 14 weeks. During the study, researchers assess participants using the Eustachian Tube Dysfunction Questionnaire after 2 weeks. Additional measurements include blood pressure, respiratory rate, pulse, and various health and mood questionnaires, as well as tympanometry results. These assessments help monitor health status and treatment effects throughout the trial period ending in October 2025.

Researchers are evaluating the effect of the Shitali Respiratory Rehabilitation Program in patients with obstructive sleep apnea, a condition that negatively affects blood pressure, sleep quality, and breathing. This study involves 40 patients with mild to moderate obstructive sleep apnea, divided equally into two groups to compare the impact of the rehabilitation program. One group will perform six cycles of 5-minute Shitali respiratory pranayama exercises three times daily morning, afternoon, and evening for 12 weeks. The other group will serve as a control and will not receive any intervention during this period. Participants will be assessed before and after the 12-week period for several outcomes including the apnea hypopnea index, blood pressure systolic and diastolic, sleep quality using the Pittsburgh Sleep Quality Index, respiratory rate, daytime sleepiness with the Epworth Sleepiness Scale, and sleep difficulty reported by a partner using a visual analogue scale. These measures will help determine the programs impact on their sleep apnea and related symptoms.

Researchers are studying the effect of walking exercise with a dog on people who have both chronic subjective tinnitus and mild obstructive sleep apnea. This trial aims to see how combining walking exercise with diet restriction compares to diet restriction alone for managing these conditions. The study involves adult participants who are obese and have mild sleep apnea, focusing on improving their tinnitus symptoms and sleep quality. Participants will be divided into two groups of 20 each. Both groups will follow a low-calorie diet for 12 weeks. One group will also take part in free walking sessions with a dog for 30 minutes, three times a week. The other group will follow the diet only without the walking exercise with a dog. During the 12-week study, researchers will assess tinnitus severity using the tinnitus handicap inventory and measure discomfort and loudness with visual analog scales. They will also evaluate sleep apnea severity, daytime sleepiness, sleep quality, mood, body mass index, and waist circumference. These assessments will help understand the impact of the exercise and diet interventions on participants health and symptoms.

This research aims to evaluate the effects of electrical neuromuscular stimulation NMES applied to respiratory and leg muscles on patients with Chronic Obstructive Pulmonary Disease COPD. The study includes patients diagnosed with grade I and grade II COPD who also meet clinical criteria for restless leg syndrome, assessing how this treatment combined with conventional pulmonary rehabilitation may impact pulmonary function and leg symptoms. Participants are divided into two groups one receives active NMES with specific electrical pulses applied to the quadriceps and intercostal muscles along with a pulmonary rehabilitation program that includes breathing exercises the other group receives placebo NMES at the same locations along with the same rehabilitation program. The stimulation is delivered by electrode patches placed on targeted muscle areas, and the treatment is given over a 10-week period. Throughout the study, participants undergo evaluations including the dynamic gait index, pulmonary function tests, dyspnea assessment, restless leg syndrome questionnaires, sleep quality measurement, and chronic respiratory disease questionnaires. These assessments occur at the start and end of the 10 weeks to monitor changes. The study also ensures monitoring for safety and adherence, with participation expected to last around 10 weeks.

This research aims to explore how elliptical physical activity affects sexual dysfunction, specifically weak erection or erectile dysfunction, in men with irritable bowel syndrome IBS. Psychological issues related to IBS may contribute to sexual problems, and different forms of exercise might help improve these symptoms. The study focuses on men aged 30 to 50 years who experience both IBS and sexual dysfunction. Forty men with IBS and sexual dysfunction will be randomly assigned to one of two groups. Group I will participate in elliptical physical activity for 40 minutes, three times a week, over 12 weeks. Group II will not perform any physical activity and will serve as a wait-list control group. This single-blind trial evaluates the impact of exercise compared to no intervention. Participants will be assessed after 12 weeks using several measures, including the International Index of Erectile Function to evaluate sexual function. Additional assessments include the Irritable Bowel Syndrome Severity Scoring System, Quality of Life Questionnaire, State Anxiety Inventory, and Beck Depression Inventory. These evaluations will help researchers understand the effects of elliptical exercise on sexual dysfunction and related psychological symptoms in men with IBS.