Jouy En Josas

Researchers are investigating how probiotics that increase butyrate production can improve gut health and balance the microbiota. Butyrate is a key short-chain fatty acid that supports intestinal cells, strengthens the gut barrier, and reduces inflammation. The study focuses on adults aged 20 to 80 years and explores the link between butyrate production and beneficial effects on digestion, immunity, and overall wellness. The study involves isolating and identifying probiotic bacterial strains from stool samples that are known to produce or stimulate butyrate production. This observational research will monitor these strains over up to three years to understand how they interact with the microbiota and the host. No specific treatments or interventions are administered, as this is a study of natural bacterial populations. Participants will provide stool samples for bacterial analysis using gene sequencing methods. Researchers will measure the number of butyrate-producing strains present and evaluate their potential benefits. The study also tracks participants health, diet, and lifestyle factors such as exercise and body mass index. The goal is to develop probiotic products based on these findings to support gut health.

Researchers are exploring how the community of microorganisms in the gut, including bacteria and viruses called phages, affect health by defending against pathogens, regulating the immune system, and aiding digestion. This study focuses on how phages found in dairy foods might help restore gut balance and diversity, especially after disturbances caused by antibiotics or extreme diets that disrupt the microbiota. The study involves collecting stool samples from healthy adult volunteers aged 18 to 60 who follow a varied and balanced omnivorous diet. It aims to model how dairy-derived phages influence the gut microbiomes recovery following antibiotic-related changes. The research will evaluate the role of these phages in promoting the restoration of intestinal homeostasis and overall microbial diversity. Participants will provide stool samples for analysis, and researchers will monitor gut microbiome shifts over up to three years to assess the impact of phages from dairy products. The study measures primary and secondary outcomes related to microbiome changes during this period. No treatments or interventions are administered, as this is an observational study involving healthy volunteers without specific diseases.

This research aims to develop a special infant formula to support healthy gut colonization and improve the lipid makeup for babies born by caesarean section. These babies, representing about 20% of births in France, often face short- and long-term health challenges due to altered microbiota from cesarean delivery. The study focuses on creating a nutritional option tailored to their unique needs, addressing a gap where no specific care currently exists for this group. The project involves isolating beneficial probiotics from breast milk and stool samples of vaginally born babies and breastfeeding mothers, then formulating an enhanced milk enriched with these probiotics and natural bioactive lipids like DHA and alkylglycerols. The formula will be evaluated preclinically for its potential benefits in a cesarean birth model, aiming to mimic the protective effects of breast milk that cesarean-born infants may miss. Participants include breastfeeding mothers aged 18 and older who have breastfed for less than six months and their exclusively breastfed babies under six months born vaginally at term. Researchers will collect breast milk and stool samples to study the viability of supplemented probiotics and levels of bioactive lipids in the developed formula over up to three years. The study will monitor the safety and potential impact of this optimized nutrition on infant health and development.