Noisy Le Grand

This research investigates the effects of the Terre de Joie educational kit on childrens well-being and empathy in school. The study is a multicenter, randomized trial involving 58 classes of children aged 7 to 11 years. It compares classes using the Earth of Joy program with those continuing regular lessons, aiming to assess improvements in well-being, empathy, bullying behaviors, and classroom climate. In the study, 26 classes will implement the Earth of Joy program for 10 weeks, featuring classroom activities centered on joy, empathy, and well-being. Another 26 classes will continue their usual lessons without the program. Assessments are conducted before and after the intervention using self-questionnaires to measure changes in the childrens well-being and empathy. Participants will complete questionnaires at two time points, in September and December 2025, to evaluate changes in school well-being, empathy, bullying, teacher well-being, and classroom cohesion. The study will monitor these outcomes to understand the programs impact on childrens social and emotional health over the 10-week period.

Researchers are exploring how combining yoga therapy with Eye Movement Desensitization and Reprocessing EMDR might help women suffering from complex post-traumatic stress disorder PTSD related to childhood sexual abuse. This study compares the effects of yoga plus EMDR with EMDR alone, aiming to see if the combination improves treatment success. The yoga technique used is trauma-sensitive yoga, designed to help regulate emotional and cognitive functions. Participants will be randomly assigned to one of two groups one group will receive 10 sessions of yogatherapy combined with EMDR treatment, while the other group will receive EMDR treatment without yogatherapy. This approach is intended to prepare patients for trauma work by improving self-awareness, emotional regulation, and a sense of self-efficacy. Throughout the study, participants will be assessed at various points, including the first week, tenth week, and twentieth week, using standardized scales for PTSD symptoms such as the PCL-5 and CAPS-5. These evaluations will help measure the changes in PTSD symptoms over time. The study monitors participants progress closely to understand how these therapies affect their condition.

This research aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation rTMS on patients with schizophrenia who experience resistant auditory hallucinations. The study compares two stimulation methods, rTMS and continuous theta-burst stimulation cTBS, used alongside antipsychotic medications. The main goal is to observe changes in hallucinations using the Auditory Hallucinations Rating Scale AHRS from the start of treatment to its completion. Participants receive one of two treatments at the left temporo-parietal junction. The rTMS method involves 20 sessions over 2 weeks, with two 20-minute sessions per day separated by a one-hour break. The cTBS method lasts 15 days with 45 sessions, each lasting 40 seconds and including specific pulse patterns, given three times daily with 15-minute breaks between sessions. Both treatments are provided under naturalistic, routine practice conditions. During the study, participants will be assessed using the AHRS at baseline, end of treatment, and follow-ups at 1 and 3 months. Additional evaluations include response rates based on AHRS score changes, symptom severity scales, cognitive tests, mood assessments, addictive behavior questionnaires, quality of life measures, and global clinical impressions. This comprehensive monitoring helps track treatment effects and overall participant well-being throughout and after the treatment periods.

Schizophrenia, affecting about 0.7% of the population, often leads to poor insight and medication compliance, resulting in relapses and a reduced quality of life. Researchers are evaluating an individual early psychoeducation program called PEPITS for inpatients with schizophrenia or related disorders. The study aims to see if PEPITS can reduce relapses, improve medication adherence and insight, and enhance quality of life. The PEPITS program is delivered by nurses during the initial hospitalization phase and consists of three parts an introduction session, sessions focused on understanding the illness and care, and sessions on recovery and building coping skills. Participants are randomly assigned to either the PEPITS program or to usual psychiatric care without PEPITS. Participants will be monitored from the start of the study until one year after randomization to assess changes in insight, quality of life, and medication compliance. Additional evaluations include quality of life and psychological well-being at work, job satisfaction, self-efficacy, and work commitment over six months. The study involves regular assessments to track these outcomes and better understand the programs impact.

Researchers are exploring the use of sailing as a therapeutic activity integrated into psychosocial rehabilitation for adults living with severe psychological or neurodevelopmental disorders. This study aims to evaluate the impact of sailing on psychosocial rehabilitation outcomes and aligns with the national Sport Sant plan, which promotes sport as a therapeutic approach. The project is a partnership between the Ville-Evrard hospital and a local sailing committee to enhance care options for people with psychiatric disorders in Seine-Saint-Denis. Participants are divided into two groups one group takes part in sailing activities consisting of 10 sessions over two periods each year March to June and August to November, while the control group receives standard psychosocial rehabilitation care without sailing. The study is non-randomized and behavioral in nature, comparing outcomes between those who engage in sailing and those who do not. Throughout the study, researchers will assess quality of life, mental well-being, and self-esteem using standardized scales at three time points before the sailing program starts, immediately after completion, and three months later. The study will monitor participants over these periods to understand the lasting effects of sailing on psychosocial health. Participation includes regular sailing sessions or rehabilitation care, with evaluations conducted at specified intervals to measure impact and safety.

Researchers are evaluating a group-based intervention called deux, cest mieux Better Together designed to improve romantic and social relationship skills in adults living with severe mental illnesses such as schizophrenia, bipolar disorder, or major depressive disorder. Many adults with these conditions experience loneliness, social isolation, and difficulty forming romantic relationships despite a strong desire for intimacy. The study aims to determine if this intervention improves romantic and social functioning, quality of life, and overall well-being. The intervention consists of a structured program with 12 weekly group sessions led by trained mental health professionals. These small groups of 4 to 6 participants explore topics like attraction, communication, emotional intimacy, attachment-related anxiety, and sexuality. The program uses discussions, exercises, and practical strategies to enhance communication, emotional regulation, social understanding, and healthy romantic relationship behaviors, welcoming all sexual and gender identities. Participants will complete assessments before the program starts, immediately after the 12 sessions, and again three months later. Researchers will measure changes in romantic relationship functioning, quality of life, loneliness, self-esteem, internalized stigma, and recovery. The study uses a design where each participant serves as their own control to track progress over time. This study lasts from the initial assessment through the three-month follow-up after the intervention.

Researchers are evaluating the effectiveness of a group psychoeducation program designed to help individuals with severe psychiatric disorders, such as mood or psychotic disorders, improve their autonomy at home. This observational study focuses on participants supported by the RPS platform in Seine-Saint-Denis and aims to assess their daily living skills before and after the program. Participants take part in a 10-week psychoeducation program called AUTONHOME, consisting of 10 thematic sessions covering cognitive functions, daily living skills, hygiene, housing management, and social participation. The study involves groups of six patients each, and evaluations are done before starting the program and three months after its completion. During the study, researchers assess participants using various tools, including the Life Habits Assessment Tool at baseline, at the end of the program, and three months later. Additional assessments include depression scales, burden interviews, family expectations, symptom severity, clinical impressions, and cognitive function tests. The study aims to monitor changes in autonomy and mental health over time, with participation lasting throughout the program and follow-up periods.

Researchers are evaluating how cannabis use affects the hospitalization and short- and medium-term outcomes of patients with psychotic symptoms. This observational study aims to compare patients with psychotic symptoms who use cannabis to those who do not, focusing on hospitalization duration, risk of resistance to usual therapies, therapeutic alliance, relapse frequency, symptom severity, and behaviors such as impulsivity and aggression. The study is sponsored by the Centre hospitalier de Ville-Evrard, France. Participants hospitalized for psychiatric reasons and presenting psychotic symptoms, with or without protective measures, are observed for how cannabis consumption may influence their hospital stay and short-term prognosis. The study does not involve any experimental treatments but collects clinical data and assessments during hospitalization and after discharge to understand these impacts. During the study, participants undergo evaluations using various scales including the Positive and Negative Syndrome Scale PANSS, Marijuana Craving Questionnaire-Short Form MCQ-SF, Clinical Global Impression CGI, Montgomery sberg Depression Rating Scale MADRS, Psychotic Depression Scale PDS, Young Mania Rating Scale YMRS, Self-Consciousness Revised Scale CDS, Childhood Trauma Questionnaire CTQ, and Big Five Inventory BFI. These assessments are performed at the beginning of the study, at discharge, and one and three months after discharge to monitor symptoms, craving, mood, and behavior over time. The study spans several months to track participant progress and hospital outcomes.

Researchers are evaluating the effectiveness of repetitive Transcranial Magnetic Stimulation rTMS on the negative symptoms of schizophrenia in real-world conditions. This study aims to provide a regulatory framework for rTMS treatments by comparing four different rTMS protocols adapted to patients tolerances. The treatment duration ranges from 2 to 4 weeks, followed by a 3-month follow-up period to observe relapses. The main measurement used to assess changes in negative symptoms is the Scale for the Assessment of Negative Symptoms SANS. Participants receive one of four different rTMS protocols. These include daily sessions for 20 working days or twice daily sessions for 10 or 20 working days, with varying frequencies and stimulation intensities. Each session lasts between 20 and 50 minutes, involving specific patterns of magnetic pulses and intervals. Patients sit in a chair with hearing protection during treatment, and a caregiver is present throughout each session. After treatment, patients are clinically reassessed for potential side effects. During the study, participants undergo clinical assessments using several scales including SANS, PANSS, CGI, MOCA, STROOP, MCQ, CAST, CDSS, and S-QoL-18 to evaluate symptom changes, cognitive function, mood, addictive behaviors, quality of life, and adverse reactions. These evaluations occur at baseline, end of treatment, and multiple follow-up points up to 24 weeks post-treatment. Safety is monitored closely, with a doctor available if adverse reactions occur. Total participation spans the treatment period plus up to 24 weeks of follow-up.