Noisy Le Grand

This research focuses on women diagnosed with Complex Post-traumatic Stress Disorder (PTSD) related to childhood sexual abuse. It aims to evaluate the combined effect of trauma-sensitive yoga and Eye Movement Desensitization and Reprocessing (EMDR) therapy. Previous studies have shown yoga alone can reduce PTSD symptoms and improve emotional regulation, self-awareness, and self-efficacy, but it has not been tested alongside conventional trauma treatments like EMDR. Participants are divided into two groups: one group will receive 10 sessions of trauma-sensitive yoga combined with EMDR therapy, while the other group will receive only EMDR treatment. The yoga approach used is specifically adapted to address psycho-trauma and aims to prepare patients for trauma memory work. This setup allows researchers to compare the outcomes of combined therapy versus EMDR alone. During the study, participants’ PTSD symptoms will be assessed using the PCL-5 scale at the first week and again at twenty weeks. Researchers will monitor the effects of the treatments on symptom severity over time. The study also includes informed consent procedures and excludes individuals with certain neurological or severe medical conditions, pregnancy, or inability to consent. The overall participation duration includes initial assessments and follow-up evaluations related to the treatments.

Researchers are evaluating the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in routine clinical practice for patients with schizophrenia who experience resistant auditory hallucinations. This study compares two stimulation methods: the rTMS method and the continuous theta burst stimulation (cTBS) method. The main goal is to assess whether rTMS, alongside antipsychotic treatment, can improve resistant auditory hallucinations using the Auditory Hallucinations Rating Scale (AHRS). Participants will receive treatment with either the rTMS or cTBS method under naturalistic conditions during routine care. Both methods involve brain stimulation techniques aimed at reducing auditory hallucinations. Treatment is delivered as part of the patients' usual clinical management without additional experimental procedures. Throughout the study, participants will be evaluated at baseline, at the end of treatment, and again at 1 month and 3 months post-treatment using the AHRS to measure changes in auditory hallucinations. This allows researchers to monitor the evolution of symptoms over time and assess the sustained effects of the stimulation methods. Participation includes signing informed consent and undergoing regular clinical assessments during the study period.

Schizophrenia is a condition affecting about 0.7% of people and often involves poor insight, which can lead to poor medication adherence, relapse, and rehospitalization, negatively impacting quality of life. Psychoeducation has shown potential to improve treatment compliance and the therapeutic relationship. This trial evaluates an individual early psychoeducation program called PEPITS, designed to support patients during the initial hospitalization phase to improve insight, medication adherence, and reduce relapse. The PEPITS program is delivered by nurses and consists of three main phases: an introduction phase, a pathology and care phase, and a recovery and "stepping stone" phase. Each phase involves several sessions that provide patients with information, key knowledge, and new skills related to their illness and recovery process. Participants in the study will either receive the PEPITS program alongside usual psychiatric care or just the usual care without PEPITS. Participants will be followed for one year after randomization. Researchers will assess changes in patients' insight over this period as the primary outcome. Throughout the study, patient progress, relapse, and medication adherence will be monitored to evaluate the program's impact. The total participation lasts up to one year, allowing detailed observation of the program's long-term effects.

Researchers are exploring the use of sailing as a therapeutic activity within psychosocial rehabilitation for adults living with severe psychological or neurodevelopmental disorders. This approach aligns with France's national Sport Santé strategy (2019-2024), which promotes sport as a recognized non-drug therapy integrated into hospital and ambulatory care. The study aims to evaluate and share the benefits of sailing as part of psychiatric care in the Seine-Saint-Denis territory, following four years of implementing this innovative intervention at the Ville-Evrard hospital's Psychosocial Rehabilitation Reference Unit (UNIRRE 93). Participants in the study include users of the psychosocial rehabilitation unit who engage in either sailing sessions or standard psychosocial rehabilitation without sailing. The sailing group participates in 10 sailing sessions conducted twice a year across two periods: March to June and August to November. The control group receives usual psychosocial rehabilitation care over the same timeframe without the sailing activity. Throughout the study, participants' quality of life, mental well-being, and self-esteem are measured before sailing begins, immediately after the sessions end, and again three months later using validated scales. The research monitors these outcomes to assess the impact of sailing as a therapeutic intervention, contributing to psychosocial rehabilitation care options. The study includes adults over 18 years old living in the 93 area with stabilized clinical conditions, and it excludes pregnant or breastfeeding women and those experiencing psychiatric decompensation.

Researchers are evaluating a group-based program called "À deux, c'est mieux" designed to improve romantic and social relationship skills in adults living with severe mental illnesses such as schizophrenia, bipolar disorder, or major depressive disorder. Many adults with these conditions experience loneliness, social isolation, and difficulties forming romantic relationships despite a strong desire for intimacy. This study aims to see if the program can improve romantic and social functioning, quality of life, and overall well-being for these adults. The intervention consists of 12 weekly group sessions led by trained mental health professionals, with groups of 4 to 6 participants. The sessions follow a structured progression starting from topics like attraction, communication, and relationship initiation, then moving to more sensitive areas such as emotional intimacy, attachment-related anxiety, and sexuality. The program uses group discussions, experiential exercises, and practical strategies and is inclusive of sexual and gender diversity. Participants will be assessed at three points: before starting the program, after completing the 12 sessions, and three months after the intervention ends. Researchers will measure changes in romantic relationship functioning as the primary outcome, along with quality of life, loneliness, self-esteem, internalized stigma, and recovery. The study employs a design where each participant serves as their own control, tracking improvements over time without a separate inactive group.

Researchers are evaluating the effectiveness of group psychoeducation programs designed for people with severe psychiatric disorders and their caregivers. The study aims to help these individuals gain greater autonomy in their home environments by focusing on improving daily living skills and cognitive functions through structured group sessions. Participants will take part in a 10-week psychoeducation program consisting of group sessions that address various aspects of independent living. These sessions are intended to support users and carers in managing psychiatric conditions and enhancing self-sufficiency at home. Throughout the study, the autonomy of participants will be assessed using the Life Habits Assessment Tool at three points: before starting the program, immediately after the 10-week program, and again three months later. This allows researchers to monitor changes over time and evaluate the lasting impact of the psychoeducation intervention.

Researchers are studying how cannabis use affects patients with psychotic symptoms during hospitalization and their short- and medium-term outcomes. The study compares patients who use cannabis with those who do not, focusing on hospital stay length, response to treatments, therapeutic relationships, relapse rates, symptom severity, and behaviors such as impulsivity and aggression. The goal is to better understand the impact of cannabis on the course and prognosis of psychotic disorders. This observational study involves patients hospitalized in psychiatric settings with various psychotic disorders, including schizophrenia, schizoaffective disorder, and substance-induced psychotic disorder. Participants may have protective measures like guardianship. The study does not involve experimental treatments but observes patients' conditions and histories related to cannabis use during their hospital stay and afterward. Participants will be assessed using multiple scales such as the Positive and Negative Syndrome Scale (PANSS), Marijuana Craving Questionnaire, Clinical Global Impression, Montgomery Åsberg Depression Rating Scale, and others. These assessments occur at the start of the study, on discharge day (about 2 to 3 weeks later), and at one and three months after discharge. Researchers will monitor symptom changes, relapse, and quality of remission over this period to evaluate cannabis's influence on psychotic illness progression and hospitalization outcomes.

Researchers are evaluating the effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) on the negative symptoms of schizophrenia in real-world conditions. This study aims to provide a regulatory framework for rTMS treatments and offers four different rTMS protocols tailored to patient needs and tolerances. The study includes a treatment period lasting between 2 and 4 weeks, followed by a 3-month follow-up to monitor any relapses. The treatment involves the patient sitting in a chair with hearing protection, while a caregiver is present throughout the rTMS sessions. The stimulation coil is positioned according to a specific targeting method, and patients are clinically reassessed after each session for any adverse effects. If any adverse reactions occur, a doctor is immediately available on site. Treatments are designed to adapt to each patient's condition and tolerance. Participants will have their negative symptoms assessed using the Scale for the Assessment of Negative Symptoms (SANS) from the start of treatment to the end (2 to 4 weeks). The study monitors the evolution of symptoms and safety during treatment and through the 3-month post-treatment follow-up. This allows researchers to observe any changes in symptoms and the potential for relapses over time.