Paderno Dugnano

This research aims to create and analyze a national multicenter database of patients in Italy affected by hypoparathyroidism or pseudohypoparathyroidism, two rare endocrine diseases affecting calcium regulation. The studys purpose is to collect detailed medical, genetic, diagnostic, clinical, and treatment data from a large number of patients to better understand these conditions, their prevalence, incidence, and clinical features. This observational study does not involve interventions but focuses on gathering valuable information to improve patient care and knowledge over time. The study will involve 41 specialist clinical centers across Italy, including endocrinology and pediatric departments, collecting data from patients of any age and gender diagnosed with chronic hypoparathyroidism or pseudohypoparathyroidism. Data collection will be both retrospective and prospective, spanning 10 years from the initial recruitment visit and continuing through regular follow-up visits as part of routine clinical care. No new treatments or additional procedures beyond standard care are part of this observational study. Participants will have their health information collected anonymously, including medical history, bone health assessments, genetic testing results, biochemical measures, treatment responses, and quality of life questionnaires. Researchers will analyze these data to assess disease prevalence, clinical characteristics, bone fragility, and therapy outcomes. The study emphasizes long-term follow-up with continuous data updates during routine medical visits, aiming to enhance understanding and management of these rare diseases over a decade.

Researchers are creating and managing a national multicenter database in Italy to study patients with parathyroid carcinoma or atypical parathyroid adenoma, two very rare types of parathyroid gland cancers. The study aims to collect and analyze detailed clinical, genetic, diagnostic, histological, and therapeutic data from a wide number of patients across 33 specialist centers throughout Italy. This observational research seeks to improve understanding of these rare tumors and guide better clinical and therapeutic management. The study involves two patient groups those with parathyroid carcinoma and those with atypical parathyroid adenoma, including both sporadic and genetic forms of the diseases. Data will be collected both retrospectively from medical records and prospectively during routine follow-up visits over a 10-year period. Treatments such as surgery and medications are those conventionally used for these conditions, with no additional interventions or visits required by the study. Participants will have their medical history, diagnostic tests, biochemical and genetic data, treatments, and follow-up outcomes recorded anonymously in the database. Researchers will assess disease prevalence, tumor characteristics, and responses to therapy over short and long terms. The study spans approximately 10 years, during which ongoing clinical data is gathered to refine medical knowledge and improve patient care for these rare parathyroid cancers.

This research aims to understand how diets enriched with polyunsaturated fatty acids PUFAs from animal or plant sources affect chronic inflammation linked to cardiovascular disease risk. The study focuses on adults over 55 years old at moderate to high cardiovascular risk, comparing the impact of these diets on a lipid and inflammation-based risk score. It also explores how these dietary changes might improve blood lipid, sugar, and inflammation markers while promoting public awareness of inflammation as a modifiable risk factor. Participants will be randomly assigned to one of three groups a daily fish oil supplement providing specific amounts of DHA and EPA, a daily vegetable oil supplement Camelina Sativa Oil rich in alpha-linolenic acid plus vitamin E, or a regular diet with vitamin E only. These supplements will be taken as liquid oils for 12 weeks, with vitamin E added to balance antioxidant intake between groups. The vegetable oil dose equals about 1500 mg of n-3 PUFAs daily, while fish oil provides slightly higher amounts. During the study, participants will have clinical visits at the start and after 12 weeks, including blood sample collection for fatty acid and biomarker analysis. Researchers will also measure heart rate, blood pressure, waist circumference, and collect dietary information through questionnaires. The main measure is a lipid and inflammation risk score derived from blood tests, and the study will evaluate how well participants accept the dietary supplements. Data from compliant participants will be analyzed to assess the effects of these dietary strategies on chronic inflammation related to cardiovascular health.