Multan Khurd

This research aims to compare the effects of autogenic drainage and mechanical percussion on lung function, breathlessness, and quality of life in children aged 6 to 12 with cystic fibrosis. Cystic fibrosis is a genetic disorder causing thick mucus buildup in the lungs, leading to breathing difficulties and lung damage. The study seeks to find which airway clearance technique better improves respiratory health and daily living for these children. Participants will be randomly assigned to one of two groups one receiving therapist-guided autogenic drainage, a controlled breathing technique to move mucus from small to large airways, and the other receiving mechanical chest percussion using a device that creates rhythmic vibrations to loosen mucus. Both groups will have supervised treatment sessions lasting about 10 minutes, five times per week, over six weeks. During the study, participants will have lung function measured by spirometry tests FEV1 and FVC, breathlessness assessed using the Modified Borg Dyspnea Scale, and quality of life evaluated with the Cystic Fibrosis Questionnaire-Revised before and after the treatment period. Researchers will analyze these results to see which technique provides greater benefits. The study may help improve airway clearance methods for children with cystic fibrosis and enhance their respiratory health and well-being.

Researchers are evaluating the effects of Mulligan mobilization with or without the Neil Asher technique on pain, shoulder range of motion, and disability in patients with adhesive capsulitis. This condition causes pain and stiffness in the shoulder joint and nearby muscles, reducing range and strength. This randomized controlled trial focuses on adults aged 40 to 60 years diagnosed with stage 2 primary adhesive capsulitis, aiming to understand how these treatments impact symptoms over four weeks. Participants will be divided into two groups randomly. Both groups receive heating pad and TENS therapy. Group A receives Mulligan mobilizations plus the Neil Asher technique, performed three times a week for four weeks, including specific shoulder mobilizations and Neil Asher sessions. Group B receives Mulligan mobilization combined with conventional physiotherapy treatments such as postural correction exercises, therapeutic exercises, and joint stretching. Both groups attend treatment sessions four times per week for four weeks. During the study, pain levels will be measured using the Numeric Pain Rating Scale, shoulder disability assessed by the Shoulder Pain and Disability Index SPADI, and shoulder range of motion measured with a Universal Goniometer at the start and after four weeks. Researchers will analyze these measurements to evaluate changes. Participants will be monitored throughout the study period, which begins in December 2024 and concludes in June 2025.

Severe pneumonia is a serious illness affecting young children and often leads to hospital admission. This clinical trial evaluates whether adding vitamin C to the standard treatment can shorten the hospital stay for children under five years old admitted with severe pneumonia. The study aims to find out if vitamin C helps children recover faster when combined with routine care compared to routine care alone. The study involves 90 children aged 2 to 59 months who have severe pneumonia, defined by symptoms like fast breathing, fever, cough, and danger signs such as difficulty feeding or bluish lips. After consent from parents, children will be randomly assigned to one of two groups. One group will receive standard treatment, including oxygen therapy and intravenous antibiotics, while the other group will receive the same standard treatment plus a daily dose of 200 mg vitamin C mixed in milk or water. Researchers will monitor each childs recovery by tracking breathing rate, temperature, oxygen levels, and overall health until the physician decides they can be discharged. The main outcome measured is the number of days spent in the hospital from treatment start until discharge, up to 30 days. This study aims to determine if vitamin C is a helpful addition to standard care for severe pneumonia in young children, potentially improving treatment and reducing hospital time.