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Found 6 Actively Recruiting clinical trials

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Actively Recruiting

Healthy Volunteer

This research evaluates the combined effects of a blow bottle device and postural drainage in patients aged 40 to 60 years with moderate to severe Chronic Obstructive Pulmonary Disease (COPD). The study compares two groups of elderly COPD patients to see how these treatments influence their lung function and symptoms like breathlessness, cough, and sputum production. The trial collects data at the Wazirabad Institute of Cardiology and applies recognized scales and tests to measure improvement. Participants are divided into two groups: Group A receives both the blow bottle technique and postural drainage, while Group B receives postural drainage with percussion. Each session lasts 20 to 25 minutes, occurring twice daily, four days per week, over eight weeks. The blow bottle technique is a device-based intervention, and postural drainage involves positioning to help clear lung secretions. During the study, lung function is evaluated using spirometry, and symptoms are assessed with scales such as the Breathlessness Cough Sputum Scale (BCSS) and the Modified Borg Rating of Perceived Exertion (RPE) scale after four weeks. Participants undergo regular assessments to track their pulmonary function and symptom changes. Data analysis will be performed using SPSS software to understand the treatments' effects.

Age: 40Years - 60YearsAll GendersPhase Not Applicable
1 location
E

Actively Recruiting

Healthy Volunteer

Adhesive capsulitis is a common condition that causes pain and stiffness in the shoulder joint and surrounding muscles, leading to reduced range of motion and strength. This research aims to evaluate how Mulligan mobilization, with or without the Niel Asher technique, affects pain, joint movement, and disability in patients with adhesive capsulitis. The study is a randomized controlled trial conducted at Ibne-siena Hospital Multan and Multicare physiotherapy clinic, involving patients aged 40 to 60 years who have adhesive capsulitis. Participants will be divided randomly into two groups. Both groups will receive a heating pad and TENS therapy. Group A will undergo Mulligan mobilization combined with the Niel Asher technique, with sessions three times a week for four weeks. Group B will receive Mulligan mobilization along with conventional physiotherapy, which includes postural correction exercises, scapular retraction, therapeutic exercises like Codman's, finger ladder, and wand exercises, and end-range gleno-humeral joint stretching. Both groups will attend treatment four times per week over the four-week period. Patients will be assessed at the start and after four weeks using the Numerical Pain Rating Scale (NPRS) to measure shoulder pain, the Universal Goniometer (UG) to measure range of motion, and the Shoulder Pain and Disability Index (SPADI) to assess shoulder disability. Data will be analyzed using SPSS software. The study includes informed consent and follows clear inclusion and exclusion criteria for selecting participants.

Age: 40Years - 60YearsAll GendersPhase Not Applicable
1 location
E

Actively Recruiting

Severe pneumonia is a serious illness common in young children, often requiring hospital admission. This clinical trial evaluates whether adding vitamin C to the standard treatment can help children under five with severe pneumonia recover faster and reduce their hospital stay. It compares vitamin C plus routine care against routine care alone in children admitted with this condition. The study involves 90 children aged 2 to 59 months admitted to the Children's Hospital Multan with severe pneumonia characterized by fast breathing, fever, cough, and danger signs like difficulty feeding or bluish lips. Participants will be randomly assigned to receive either standard treatment, including oxygen and intravenous antibiotics, or the same standard treatment plus a daily dose of 200 mg vitamin C mixed in milk or water. No experimental therapies are used. Researchers will monitor recovery signs such as breathing rate, temperature, and oxygen levels until the child meets recovery criteria set by the treating physician and is discharged. The main outcome measured is the length of hospital stay from treatment start until discharge, with follow-up lasting up to 30 days. This will help determine if vitamin C is a helpful and safe addition to standard care for severe pneumonia in young children.

Age: 2Months - 59MonthsAll GendersPhase 4
1 location
E

Actively Recruiting

Dry socket, also known as Alveolar Osteitis, is a common complication following tooth extraction. This research aims to compare the effectiveness of pure Honey dressing with Alvogyl, the most commonly used dry socket dressing worldwide, to find a natural alternative that may avoid Alvogyl's side effects and high cost. The study uses a quasi-experimental design to evaluate these treatments in patients diagnosed with dry socket. Participants will be divided into two groups of 20 each. The study group will receive a sterile gauze soaked with 2 ml of Honey applied to the extraction socket, while the control group will receive a gauze soaked with Alvogyl. Both groups may continue oral pain medication (Ibuprofen) based on pain severity, with intra-alveolar packing changed regularly until pain subsides. Treatments may be repeated up to four times over two weeks if needed. Participants will be assessed for pain relief at multiple time points: 5 minutes, 30 minutes, and 60 minutes after medication, then on the 2nd, 4th, and 7th days post-medication. They will record daily pain on a 0-10 scale and report any side effects immediately. Researchers will monitor pain levels, analgesic use, number of treatment sessions, and total healing time to categorize success as excellent, good, fair, or poor.

Age: 18Years - 70YearsAll GendersPhase 1
1 location
I

Actively Recruiting

Researchers are evaluating whether a culturally adapted, multicomponent intervention can improve survival and rehabilitation outcomes for adults with accidental burn injuries in Pakistan. This study compares an integrated case management approach to enhanced usual care, aiming to enhance both physical and psychosocial rehabilitation for burn survivors and their families. The trial is conducted across six cities including Karachi, Hyderabad, Lahore, Rawalpindi, Peshawar, and Quetta, using a randomized, parallel group design. Participants in the intervention group receive integrated case management delivered by trained allied health professionals such as nurses, physiotherapists, and psychologists. This includes 8 sessions: six low-intensity sessions lasting 30-60 minutes each, delivered during hospital stay or in the community, and two 30-minute follow-up sessions after discharge to support transition and continued care. The control group receives usual emergency, surgical, and rehabilitation care plus brief written self-help advice. Participants will be assessed at baseline, then at 3, 6, and 12 months after the intervention. Researchers will measure outcomes including all-cause mortality, hospital readmissions, and health-related quality of life using a composite score. The study also monitors treatment adherence and cost-effectiveness over the 12-month follow-up period to understand the impact of the integrated care approach compared to standard care.

Age: 18Years +All GendersPhase Not Applicable
11 locations
O

Actively Recruiting

This research aims to evaluate the effectiveness of two different rehabilitation methods for women who have had surgery for breast cancer. The study focuses on comparing tele rehabilitation, which has become popular during the COVID-19 pandemic, with traditional outpatient rehabilitation. The goal is to address a gap in knowledge about tele rehabilitation for breast cancer patients in Pakistan, where breast cancer rates are high, and to see if tele rehabilitation can reduce treatment costs and travel needs. Participants will be randomly assigned to one of two groups. One group will receive tele rehabilitation, and the other will attend outpatient rehabilitation sessions. Both groups will follow the same exercise plan based on the American Cancer Society guidelines for breast cancer patients. The exercise plan starts on the third day after surgery and includes warm-up, balance exercises, and cool-down. Each session lasts 60 minutes, occurs three times a week, and continues for four weeks, totaling 12 sessions. Patients will receive pictorial guides to help perform exercises correctly. Throughout the study, patient progress will be monitored weekly, with assessments including the Shoulder Pain and Disability Index on the third day after surgery. The study will track shoulder function and independence in daily activities. Participants must have access to a smartphone and the internet to participate. The study includes women aged 30 to 60 who have undergone mastectomy without chemotherapy or radiotherapy. Safety and treatment adherence will be carefully observed during the four-week rehabilitation period.

Age: 30Years - 60YearsFEMALEPhase Not Applicable
1 location
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