Hama

Researchers are investigating the use of injectable platelet-rich fibrin (i-PRF) to speed up orthodontic tooth movement during the leveling and alignment stage of treatment. This study focuses on patients aged 18 to 26 who need extraction of the first upper premolar due to severe irregularity of the upper incisors. The aim is to evaluate how i-PRF affects the rate of maxillary incisor leveling compared to traditional orthodontic treatment methods. Participants are divided into two groups. One group receives a 0.9 ml injection of i-PRF after the extraction of the first premolar, which contains higher levels of regenerative cells and growth factors. The other group receives a placebo injection following the same extraction procedure. Both groups undergo comprehensive orthodontic treatment, and their progress is monitored throughout the study. During the study, researchers will measure the leveling and alignment of the maxillary incisors at one, two, and six months. Participants will attend regular follow-up visits to assess tooth movement and oral health. The study tracks the effectiveness of i-PRF in accelerating tooth movement while monitoring safety and treatment outcomes over the entire treatment period.

This research aims to assess the effectiveness of the micro-osteoperforations (MOPs) technique in speeding up orthodontic tooth movement during clear aligner therapy for adults with moderate crowding in the lower front teeth. The study compares two groups: one receiving traditional clear aligners combined with MOPs, and the other receiving only traditional clear aligners. It also evaluates patients' pain levels and satisfaction with the treatment. Participants in the intervention group will undergo the MOPs procedure on the lower front jaw area using a special drill to create small perforations in the bone, intended to accelerate tooth movement. Both groups will receive clear aligners, with aligner changes based on fit rather than a fixed schedule. The MOPs will be performed at multiple sites on the lower jaw with specific spacing and depth to ensure consistent application. During the study, researchers will monitor changes in Little's Index of Irregularity at multiple time points up to five months, noting when the irregularity is less than 1 mm and the final aligner fits without pressure. They will also measure overall treatment time until this point. Patient pain and satisfaction will be tracked. The total participation period includes the orthodontic treatment duration and evaluations over several months.

Researchers are evaluating the effectiveness of clear aligners combined with Class II elastics in treating patients aged 15 to 20 with mild Class II division 1 malocclusion characterized by a slight increase in overjet. This study compares the skeletal, dental, and soft tissue changes from this treatment approach to those achieved with traditional fixed multibracket appliances using Class II elastics. The goal is to assess how well these two methods correct the malocclusion. Two groups of patients will be treated: one will receive clear aligners applied to both upper and lower arches along with Class II elastics attached from the precision-cut hook on the maxillary aligner to the button on the mandibular first molar. The other group will undergo traditional fixed multibracket treatment with specific archwire sizes and MBT prescription. After alignment is complete, elastics will be applied from canine bracket hooks to lower first molar hooks using stainless steel archwires. Treatment duration is expected to be 4 to 6 months for the clear aligner group and up to 12 months for the traditional treatment group. Participants will be monitored through dental measurements taken one day before starting treatment and again once a normal overjet and Class I canine relationships are achieved. These measurements include various angles and lengths related to jaw and teeth positioning. The study focuses on changes in these skeletal and dental parameters along with overjet and overbite correction. Patient oral hygiene and periodontal health will also be assessed throughout the study to ensure safety and treatment effectiveness.

Researchers are studying patients aged 10.5 to 13 years with skeletal class II malocclusion caused by a retracted lower jaw. The study compares the effects of a modified Twin-Block Appliance with clear plates to the traditional Twin-Block Appliance. The goal is to assess the changes in skeletal, dental, and soft tissues resulting from these treatments in patients with this type of malocclusion. Participants will be divided into two groups: one group will receive the modified Twin-Block Appliance with clear plates, and the other will receive the traditional Twin-Block Appliance. Both treatments involve applying appliances to the upper and lower arches for 17 hours daily. The treatment duration is expected to be about 6 to 9 months until a normal overjet and canine class I relationships are achieved. Throughout the study, researchers will measure changes in several dental and skeletal parameters, including the SNA angle, SNB angle, mandibular length, overjet, and vertical position of incisors. Measurements will be taken one day before treatment begins and again when the desired dental relationships are reached. The study monitors these outcomes to evaluate the effectiveness of each appliance type in treating skeletal class II malocclusion.