Isparta Merkez

This research aims to evaluate the outcomes of surgically treated acute traumatic peripheral nerve injuries in the upper extremity, focusing on their long-term effects on sensory and motor functions, overall functional status, and quality of life. The study observes patients with nerve damage resulting from trauma to the nervous system, particularly injuries involving the median, ulnar, radial nerves, or combinations of these. Participants will undergo standard clinical and functional assessments to monitor the status of their nerve injuries. These assessments include evaluating motor and sensory functions and overall hand functionality without being assigned to a specific treatment. The study observes different nerve injury types such as ulnar nerve, median nerve, or combined injuries. During the study, participants will be evaluated at six months after injury using tools like the Michigan Hand Outcomes Questionnaire to assess hand function, grip strength measured by a dynamometer, Semmes-Weinstein monofilament test for sensation, and static two-point discrimination test. The study period involves regular clinical and functional evaluations to track recovery and impact on quality of life over time.

Researchers are evaluating the effects of a triple therapy inhaler combining budesonide, glycopyrronium, and formoterol fumarate BGF MDI 32014.49.6 g compared to a dual therapy inhaler with glycopyrronium and formoterol fumarate GFF MDI 14.49.6 g on heart and lung outcomes in adults with Chronic Obstructive Pulmonary Disease COPD who have a higher risk for heart and lung events. This Phase III study is randomized, double-blind, and conducted at multiple centers, focusing on participants with COPD and elevated cardiopulmonary risk. Participants will receive either the triple therapy inhaler or the dual therapy inhaler, both administered twice daily. The study compares these two inhalers over a period of up to three years, monitoring for serious cardiac or COPD events. The trial includes careful evaluation of various heart and lung-related health events during this period. During the study, participants will be closely monitored through regular visits, assessments, and tests to measure lung function, heart events, and COPD exacerbations. Researchers will track the time until the first severe cardiac or COPD event and evaluate other cardiovascular and respiratory outcomes over up to three years. Participants will also be assessed for their ability to properly use the inhaler and adherence to the study protocol throughout the trial.

This research aims to evaluate the safety, performance, and usability of several Occlutech accessory medical devices used in heart disease treatment. These devices include the Occlutech Delivery Set ODS, Occlutech Pistol Pusher OPP, Occlutech Occlusions-Pusher OOP, and Occlutech Sizing Balloon OSB. The study is international, multicenter, non-randomized, and non-invasive, focusing on catheter-based implantation procedures for cardiac implants. The study involves physicians experienced in cardiac catheterization using these accessories during implantation procedures. Investigators complete detailed surveys to assess each devices safety, including success of implantation, adverse events during or after the procedure, user harm, and any device deficiencies. The surveys also evaluate the performance, usability, and compatibility of these accessories with other devices. Subjects receive treatment following standard clinical routines and specific instructions for use. Participants who have undergone implantation with an Occlutech accessory and cardiac implant are included. Researchers monitor safety events and assess device performance and usability over a 6-month period. Data is collected via investigator questionnaires, focusing on implantation outcomes and any related complications. The total participation duration varies depending on individual follow-up but includes at least 6 months of monitoring for safety and performance.

This research aims to evaluate the effects of game activity and stress ball use on preoperative anxiety and vital signs in patients undergoing total knee arthroplasty. The study focuses on adults over 18 who are cognitively competent as tested by the Mini-Cog. Anxiety before surgery can negatively impact surgical outcomes and patient satisfaction, so managing it is important in this population. The trial compares these two distraction methods against a control group receiving no intervention. Participants are randomly assigned to one of three groups one group plays a designated game with a researcher and a relative before surgery, another group uses a stress ball for 15 minutes prior to surgery, and the control group receives no intervention. Data collection occurs before and after the interventions or at matched times for the control group. The interventions are simple, low-cost, and designed to be easy for patients to use. During the study, researchers collect data using the State Anxiety Inventory and record vital signs including temperature, blood pressure, heart rate, oxygen saturation, respiratory rate, and pain levels. Measurements are taken at the first encounter and again 15 minutes after the intervention, or one hour after the first measurement for the control group. The study monitors these outcomes to assess how the interventions impact anxiety and physiological responses before surgery.

Researchers are evaluating the effects of different oral care methods on oral mucositis, a common and painful side effect of cancer treatment, in children aged 6 to 18 years who are receiving chemotherapy. The study compares routine oral care using sodium bicarbonate with two experimental treatments saline mouthwash and black mulberry syrup mouthwash, to understand their impact on the severity of oral mucositis during chemotherapy. Participants will be randomly divided into three groups. One group will receive routine oral care with sodium bicarbonate mouthwash, while the other two groups will receive oral care with saline or black mulberry syrup mouthwash, respectively. Oral care will be performed four times a day for 14 days. The study involves a randomized controlled design with quadruple masking. Childrens oral health will be assessed using the International Child Mucositis Evaluation Scale ChIMES and the World Health Organization Mucositis Classification on days 1, 2, 4, 8, and 16. Neutrophil counts will also be measured during this period. Researchers will monitor changes in mucositis severity and blood counts throughout the study to evaluate treatment effects and safety during chemotherapy.

Researchers are evaluating two teaching methods, Flipped Classroom FC and Flip-Jigsaw, to see how they affect knowledge, motivation, and engagement among third-year physiotherapy undergraduate students in a public health theory course. The study aims to compare whether the hybrid Flip-Jigsaw model, which includes peer teaching, leads to better learning and motivation outcomes than the FC model, which involves pre-class videos followed by instructor-led discussions. This quasi-experimental study addresses a gap in understanding the unique benefits of Flip-Jigsaw in physiotherapy education. Participants are divided into two groups receiving the same video lectures before class. The FC group attends instructor-led interactive discussions and case analyses during class, emphasizing self-paced learning with guided reinforcement. Meanwhile, the Flip-Jigsaw group engages in structured peer teaching using the Jigsaw technique, where students become experts in subtopics before teaching their peers in mixed groups, with the instructor facilitating but not leading content delivery. The study lasts 7 weeks and compares these two active learning models. Throughout the study, students complete pre- and post-knowledge tests, motivation surveys, and participation assessments to measure theoretical knowledge, motivation, and engagement immediately after the intervention. The study uses quantitative tests and qualitative interviews, with assessors blinded to group assignments during practical exams to ensure objectivity. Participants must attend the compulsory course, have internet access, and complete all assessments over the 7-week period to contribute data to the study outcomes.

This research aims to study salivary biomarkers linked to bone changes during the progression from healthy gums to gingivitis and periodontitis. These chronic inflammatory conditions cause destruction of the tissues supporting the teeth, including connective tissue and alveolar bone. The study evaluates how levels of specific salivary markers relate to disease stages and severity, hoping to improve early diagnosis and personalized treatment. Participants include individuals with healthy gums, gingivitis, or periodontitis. Unstimulated saliva samples will be collected and analyzed for markers such as IL-17, IL-23, IL-6, TGF-, RANKL, and OPG using ELISA methods. Participants will be grouped based on their periodontal status, with saliva collection occurring once at baseline to compare biomarker levels. During the study, participants will provide saliva samples and undergo clinical periodontal examinations to classify their disease stage. Researchers will measure the salivary concentrations of inflammatory and bone remodeling biomarkers at baseline. The findings aim to deepen understanding of periodontal disease mechanisms and explore non-invasive tools for early detection. The study runs from July 2025 to August 2026, involving adults aged 18 to 65.

Researchers are investigating the relationship between how patients with knee osteoarthritis perceive bodily sensations, their psychological and functional status, and the pain they experience. The study focuses on patients aged 40 to 84 who have had knee pain due to osteoarthritis for at least six months. This research aims to better understand how these factors connect, as current studies have not fully explored their interrelation or how they might guide evaluation and treatment. Participants will be assessed using various questionnaires to measure somatosensory amplification, fear of movement kinesiophobia, pain levels, depression, and functional status. These tools include the Somatosensory Amplification Scale, Tampa Kinesiophobia Scale, Visual Analog Scale for pain, Beck Depression Inventory, and the Western Ontario and McMaster Universities Arthritis Index. Sociodemographic information such as age, weight, height, and education level will also be collected. During the study, patients will complete these assessments within a two-week period. Researchers will analyze the data using statistical methods to identify correlations between the psychological and physical factors and pain levels. The study will monitor participants responses and characteristics to better understand their condition, with the total participation lasting up to two weeks.

Researchers are evaluating the impact of a Peer Leadership Program on nursing students abilities, including empathic self-confidence, social confidence, and youth leadership traits. The study focuses on nursing students in their second, third, or fourth year at Sleyman Demirel Universitys Faculty of Health Sciences during the 2024-2025 academic year. The aim is to understand how the program influences these personal and leadership qualities. The program involves selecting volunteer peer mentor students who are randomly assigned mentors. Over six weeks, these peer mentors receive training in communication, interview techniques, empathic approaches, social motivation, and leader-member interaction. They also share related podcasts and participate in a group presentation and evaluation meeting themed Nursing and Society with their mentees. Participants will be assessed before and after the program on their perceived empathic self-efficacy, social self-efficacy, and youth leadership traits. Socio-demographic information will also be collected. The study measures changes using specific scales, with evaluations occurring at the start and after six weeks. The study is conducted without masking or blinding.

This research aims to compare the effects of yoga and Whole Body Vibration Training on pelvic floor muscle strength, the severity of urinary symptoms, and quality of life related to urinary incontinence in women. The study focuses on women aged 20 to 60 years with stress urinary incontinence SUI or mixed urinary incontinence with a predominant SUI component who have not had physical therapy treatment in the last 3 months. The trial is sponsored by Suleyman Demirel University and uses a randomized design with single masking. Participants are assigned to one of three groups a yoga group combined with home pelvic floor muscle exercises, a whole body vibration training group combined with home exercises, or a home exercise only group. Yoga sessions are planned three times a week for 45 minutes over six weeks, practicing specific poses such as mountain pose, chair pose, and supported bridge pose. Whole body vibration training lasts 45 to 55 minutes including warm-up, active training, and cooling phases. The home exercise group performs pelvic floor muscle training daily for six weeks, involving slow and fast contractions in various positions. During the six-week intervention, researchers will assess pelvic floor muscle strength, urinary symptom severity, incontinence impact on quality of life, and urogenital distress using several validated tests and questionnaires, including a 1-hour pad test and the International Consultation of Incontinence Society-Short Form. The study will analyze these outcomes statistically to evaluate the effects of the different interventions on stress urinary incontinence in women.