Study of Sodium Bicarbonate, Saline, and Black Mulberry Syrup for Oral Mucositis in Children Aged 6 to 18 Receiving Chemotherapy

What this Trial Is About

Researchers are evaluating the effects of different oral care methods on oral mucositis, a common and painful side effect of cancer treatment, in children aged 6 to 18 years who are receiving chemotherapy. The study compares routine oral care using sodium bicarbonate with two experimental treatments saline mouthwash and black mulberry syrup mouthwash, to understand their impact on the severity of oral mucositis during chemotherapy. Participants will be randomly divided into three groups. One group will receive routine oral care with sodium bicarbonate mouthwash, while the other two groups will receive oral care with saline or black mulberry syrup mouthwash, respectively. Oral care will be performed four times a day for 14 days. The study involves a randomized controlled design with quadruple masking. Childrens oral health will be assessed using the International Child Mucositis Evaluation Scale ChIMES and the World Health Organization Mucositis Classification on days 1, 2, 4, 8, and 16. Neutrophil counts will also be measured during this period. Researchers will monitor changes in mucositis severity and blood counts throughout the study to evaluate treatment effects and safety during chemotherapy.

Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on Degree of Oral Mucositis in Children Receiving Chemotherapy