Ordu Merkez

Researchers are evaluating which of three common root-canal rinsing methods best reduces bacteria in adults needing root-canal treatment. The study focuses on comparing a chitosan solution alone, sodium hypochlorite followed by chitosan, and sodium hypochlorite followed by EDTA to see which method lowers bacterial levels most effectively inside the root canal. Participants are randomly assigned to one of three groups: chitosan only; sodium hypochlorite followed by chitosan; or sodium hypochlorite followed by EDTA. Each rinse involves delivering 10 mL of the solution over 30 seconds, leaving it in place for an additional 30 seconds, totaling 60 seconds of contact, followed by a 5 mL sterile saline flush. Treatment is provided during a standard root-canal procedure under local anesthesia. Participants attend two clinic visits. The first includes root-canal treatment and painless collection of samples from inside the canal before and after rinsing to measure bacterial load changes. About one week later, a second visit checks healing and completes the tooth filling. Participants record any pain or discomfort for three days after treatment in a diary or by phone. The study involves about 90 adults and includes routine dental care procedures with no cost to participants, who can withdraw anytime and ask questions throughout the trial.

Researchers are evaluating a family-centered comfort intervention for children aged 5 to 10 years who are hospitalized in a Pediatric Intensive Care Unit (PICU). The study aims to determine if adding this intervention to routine nursing care improves child comfort, anxiety, fear, and sleep, as well as parental anxiety and satisfaction. This is a randomized controlled trial based on Kolcaba's Comfort Theory, comparing the new intervention to standard care. The intervention includes listening to the mother's voice through storytelling, dimming the environmental lighting, and using a weighted blanket, all delivered by the researcher alongside routine care. Children in the control group will receive only routine nursing care. Assessments are scheduled at baseline, 24 hours after admission, and 12 hours after the intervention's completion. Participants will undergo evaluations of comfort using the COMFORT-B Behavioral Comfort Scale, along with measures of anxiety, fear, and sleep parameters. Parental outcomes such as state anxiety and satisfaction with care will also be recorded. The study involves monitoring these outcomes at specified times to compare the effects of the intervention against standard care during the PICU stay.

This research aims to investigate and compare changes in oxidative stress markers in patients with chronic apical periodontitis treated in a single session using different root canal pastes. The study focuses on whether oxidative stress markers in saliva change after root canal treatment and if these changes differ between patients treated with bioceramic-based versus epoxy resin-based root canal sealers. The trial includes systemically healthy patients diagnosed with chronic apical periodontitis in a tooth with two or more roots. Participants will undergo a single session root canal treatment using the VDW Gold Reciproc device and reciprocal files. Samples from the root canal will be collected using Hedström files during the procedure. The study compares periapical index (PAI) scores from X-rays taken before treatment with oxidative stress markers measured before and 30 days after treatment, for both the bioceramic and epoxyamine groups. During the study, saliva samples will be collected twice: once during the root canal treatment session and once 30 days later. Patients will be informed about all procedures and asked to provide informed consent. Researchers will monitor changes in oxidative stress markers biochemically and correlate these with radiographic evaluations. The total observation period is approximately three months, including treatment and follow-up assessments.

The EU-ROP registry is a European-wide, multicenter, non-interventional observational study focused on infants born prematurely who develop retinopathy of prematurity (ROP) that requires treatment. This registry aims to collect clinical routine data without performing any study-specific tests or interventions. Its purpose is to gather extensive information on the clinical features, disease progression, treatment approaches, follow-up, and long-term outcomes of severe ROP across different European countries. Infants who develop treatment-requiring ROP and receive any kind of treatment at participating centers are included in the registry. The study does not limit the number of centers or patients enrolled. Data collected includes baseline characteristics, treatment details at initial and any subsequent treatments, and disease stage through follow-up. Participants are involved through routine clinical care, with data recorded from birth through treatment and follow-up, which may extend up to about one year postnatal age. Researchers analyze treatment parameters at various points, such as initial treatment around 12 weeks and re-treatment up to 20 to 30 weeks. The registry tracks the natural history and clinical outcomes of ROP using routine clinical information without additional procedures.

Researchers are evaluating the use of regional analgesia techniques combined with pectointercostal fascial plane block (PIFB) to improve the quality of recovery after open-heart surgery performed through median sternotomy. The study aims to compare the effectiveness of recto-intercostal fascial plane block (RIFB) against the rectus sheath block (RSB) in providing pain relief and enhancing recovery, hypothesizing that RIFB will be at least as effective as RSB and offer more flexibility in clinical use. This trial focuses on patients undergoing elective on-pump cardiac surgery with the goal of improving postoperative pain management and recovery quality.

This research aims to evaluate the impact of sexual counseling based on the Extended Plissit Model on sexual function, marital adjustment, sexual quality of life, and mental health aspects such as depression, anxiety, and stress during pregnancy and postpartum. The study focuses on pregnant women between 16 and 20 weeks of gestation, addressing common declines in sexual activity and quality during pregnancy and after childbirth, as well as the cultural taboos and misconceptions that affect open discussions about sexual health in the country. Participants will be randomly assigned to an intervention or control group. The intervention group will receive sexual counseling in two face-to-face group sessions up to pregnancy week 22. Data will be collected before any intervention, after week 37 before delivery, and again three months postpartum. The counseling covers both pregnancy and postpartum periods, aiming to improve sexual health and marital harmony through education and support. During the study, participants will complete assessments including the Female Sexual Function Scale, Depression Anxiety Stress-21 Scale, Sexual Life Quality Scale for women, and Marital Adjustment Scale from pregnancy week 20 until three months postpartum. Researchers will monitor changes in sexual function, mental health, relationship quality, and overall sexual life quality. The study includes follow-up after delivery to evaluate longer-term effects of the counseling on participants' wellbeing and relationships.

Researchers are conducting a prospective, multicenter, real-world observational study to assess the use of atezolizumab as a first-line treatment in patients with stage IV non-small cell lung cancer (NSCLC) who have high PD-L1 tumor cell expression (50% or greater) and no targetable mutations. The goal is to understand how this treatment performs in routine clinical practice in Türkiye, focusing on survival, treatment response, and safety outcomes in this specific patient group. The study does not impose any additional procedures or interventions beyond standard care. Patients receive atezolizumab as prescribed in routine clinical practice, with data collected from their medical records, including imaging, lab results, performance status, treatment exposure, and safety monitoring. No specific treatment schedule is mandated, and care follows local standards at each participating center. Participants will be monitored using information gathered during regular medical visits, with researchers analyzing survival outcomes and safety trends up to 24 months. Approximately 150 patients are expected to be enrolled, allowing for an understanding of real-world treatment patterns and long-term results in this population.