Addison

Researchers are evaluating the effects of a cognitive nutritional supplement on attention and focus in adults aged 25 to 65 years. This 12-week, double-blind, randomized study compares the supplement to a placebo in a general population of men and women in the United States, aiming to assess changes in cognitive functions related to attention and focus. Participants will take either pills of the cognitive nutritional supplement or matching placebo pills daily for 12 weeks. The study is conducted in a parallel design with two groups, where neither participants nor researchers know which treatment is given. Key assessments occur at the start, midpoint week 6, and end week 12 of the study. During the study, participants will use a study-provided iPad to complete various cognitive tests measuring attention and focus, including the Feature Match test and other related assessments at weeks 0, 6, and 12. Dietary intake and nutrient consumption are also monitored through food frequency questionnaires. Safety and adherence are tracked throughout the study period, with participants following specific guidelines on diet, physical activity, and substance use to ensure consistent testing conditions.

Researchers are investigating whether using dietary supplements for more than one year is linked to differences between biological age and actual age, as well as variations in metabolic health and physical fitness. This observational study focuses on generally healthy adults aged 40 and older who have been long-term users of certain supplements. The study compares data from supplement users to non-users and those using single multivitaminmineral or multiple supplements, using a convenience sample and national health survey data. Participants in this study do not receive any intervention but are observed as part of an observational cohort. Information is collected through biomarker analysis, questionnaires, physical exams, and tests that assess physical function. Supplement users provide data at one time point, and comparison data for other groups come from the National Health and Nutrition Examination Survey NHANES. During the study visit, participants undergo assessments including blood pressure, heart rate, body measurements, muscle strength, flexibility, balance, quality of life questionnaires, cognition, and social connection surveys. Participants must fast overnight and be able to travel to the test site. The main outcome measured is the difference between biological and chronological age calculated using a validated tool. This single assessment is conducted at baseline with no further follow-up, and the total participation time is one visit.

Researchers are evaluating the effects of corn oil and avocado oil on heart and metabolic health in adults with mildly to moderately high levels of non-HDL cholesterol. The study focuses on how these oils, included in controlled diets, influence factors related to heart disease risk. This is a randomized, double-blind, controlled feeding crossover trial involving men and women aged 18 to 74 with specific cholesterol levels. Participants will consume controlled diets containing either corn oil or avocado oil for two separate 21-day periods, separated by a 21-day washout phase where they eat their regular diet. Each oil is provided in three daily servings incorporated into yogurt, dinner rolls, and muffins, delivering 4 tablespoons per day. The study includes a screening visit, baseline visit, multiple visits during each diet phase, and a visit at the end of the washout period before the second diet begins. Throughout the study, participants will visit the clinic seven times for assessments including blood draws to measure cholesterol types, triglycerides, insulin resistance, and other metabolic markers. Researchers will monitor adherence to the diets, physical activity, and health status. The primary outcome is the change in non-HDL cholesterol from baseline to the end of each diet condition, with additional measures of other cholesterol types and insulin sensitivity. The total duration of participation covers about 10 weeks including all visits and diet phases.

Researchers are evaluating the relative bioavailability of coenzyme Q10 CoQ10 from two different CoQ10 products in healthy men and women aged 21 to 65. The study compares a CoQ10 product designed for enhanced absorption with a standard CoQ10 product. This research aims to understand how each product is absorbed and processed by the body over time. Participants will receive two 50 mg capsules of either the high absorption CoQ10 product or the standard CoQ10 product, each providing a total of 100 mg. The study uses a randomized, double-blind crossover design where each participant takes both products on separate occasions, with 7 to 14 days between conditions. At the start of each test visit, participants consume the study product with water and a standardized breakfast, followed by blood sample collection over 10 hours. Standardized lunch, dinner, and snacks are provided during the test visits, and a blood draw is done the next morning 24 hours after ingestion. Participants will visit the clinic five times one screening visit and four test visits spread over two testing periods. During each test period, blood samples are collected to measure CoQ10 levels at various time points. Researchers will assess measures such as the incremental area under the curve iAUC, maximum concentration Cmax, and time to maximum concentration Tmax to evaluate the absorption of each product. The total study duration per participant is approximately 2 to 4 weeks, including the screening and test visits.

Researchers are studying the effects of daily consumption of encapsulated N-trans-caffeoyl tyramine NCT and N-trans-feruloyl tyramine NFT over four weeks on fat burning in adult women with overweight or obesity. The trial aims to compare fat oxidation at rest and over a 24-hour period between women receiving the active supplement and those given a control product. This pilot study is sponsored by Brightseed and uses a randomized, double-blind design to ensure reliable results. Participants will receive either a dietary supplement containing plant-derived phenolics or a placebo made of microcrystalline cellulose. The supplement dose is 120 mg per day, taken daily for four weeks. The study design involves two groups with treatments given in a blinded manner, meaning neither participants nor researchers know who receives the active supplement or placebo until the study ends. During the trial, women will undergo measurements on day 1 and day 28, including fat oxidation assessed by a special stable isotope tracer test at multiple time points across 24 hours, and indirect calorimetry to measure energy use. Other assessments include cardiometabolic health parameters and body weight changes. Participants will keep diet records using a personal device app and follow study procedures closely. The entire study participation lasts about four weeks, with safety and adherence monitored throughout.

Researchers are evaluating the effects of Dihydroberberine DHB supplementation in adults with pre-diabetes. The study aims to find out if DHB increases the blood levels of GLP-1, a hormone involved in blood sugar control, and how it affects appetite, mood, energy, body weight, blood sugar, and insulin. Participants will be compared to a placebo group to see if DHB has any measurable impact. Participants will take either DHB or a placebo daily for 6 weeks. The DHB group will receive four 100 mg capsules each day, totaling 400 mg daily, while the placebo group will receive four capsules containing an inactive substance. The study includes several visits during which blood and other markers related to GLP-1, glucose, and insulin will be tested after a single dose and after 6 weeks of supplementation. During the study, participants will wear continuous glucose monitors CGMs to track blood sugar levels and spend time in healthy glucose ranges. They will also rate their appetite, mood, and energy using visual scales. Researchers will assess changes in GLP-1 levels, blood sugar control, insulin resistance, and subjective feelings related to appetite and mood. The total study duration for each participant is about 6 weeks, with various laboratory tests, glucose monitoring, and questionnaires completed during this time.

Researchers are evaluating the effects of a 28-day supplementation with effera human lactoferrin compared to a placebo on gut barrier health in both males and females aged 18 to 40 years. The study aims to understand how this dietary supplement may impact indicators of gut permeability and overall gut health. Samples collected during the study will also be used to analyze lactoferrin absorption and immune biomarkers. Participants will be randomly assigned to receive either effera human lactoferrin or a placebo supplement in a double-blind manner. The study is designed as a parallel, placebo-controlled trial with masking to reduce bias. The intervention lasts for 28 days, and the primary measurement is the lactulose to mannitol ratio, which assesses gut permeability. Secondary outcomes include various markers of gut barrier function. Throughout the study, participants will be monitored for changes in gut permeability and gut barrier markers over four weeks. They will provide diet records using a smartphone app and undergo assessments including urine sample collections. The study includes safety monitoring and requires participants to adhere to lifestyle guidelines and study procedures. Overall participation lasts about one month, during which researchers will collect data to evaluate the supplements effects.

Researchers are investigating how different cranberry-based fruit juices affect blood sugar and insulin levels after eating. The study focuses on the immediate metabolic responses to these beverages, which may help clarify their role in diet and metabolic health. This trial is a randomized, controlled crossover design sponsored by Ocean Spray Cranberries, Inc., evaluating various fruit juice formulations in healthy adults. Participants will consume six different study beverages one at a time in a set order. Each visit involves drinking one type of fruit juice, followed by a 3 to 7-day break before the next beverage. The beverages include versions with zero sugar, low sugar two formulations, full sugar two formulations, and a glucose control drink. This crossover design allows each participant to experience all study products. During the study visits, participants will have blood samples taken to measure glucose, insulin, and GLP-1 hormone responses over 2 hours after consuming each beverage. Researchers will track blood sugar and insulin levels at multiple time points to assess changes and peak concentrations. The total participation period includes multiple visits spaced by wash-out periods, ensuring detailed monitoring of metabolic responses to the different juices.