Addison

Researchers are evaluating the effects of a cognitive nutritional supplement on attention and focus-related cognitive functions in healthy adults aged 25 to 65 years. This randomized, double-blind, placebo-controlled study in the United States aims to compare the supplement to a placebo over a 12-week period to understand its impact on cognition. Participants will take three capsules of either the cognitive nutritional supplement or a matching placebo daily for 12 weeks. The study is designed with parallel groups, and the supplement is provided in pill form. No additional treatments or devices are involved. During the study, participants will complete cognitive tests at the start, midpoint (week 6), and end (week 12) to evaluate attention and focus. They must avoid alcohol, marijuana/hemp products, and vigorous physical activity 24 hours before each testing day. Researchers will monitor adherence and measure cognitive changes to assess the supplement's effects compared to placebo over the study duration.

Researchers are evaluating how proprietary beverages affect amino acid levels, appetite hormones, and feelings of fullness after a meal in generally healthy adults aged 20 to 50 years. The study compares different test and control beverages to see if these drinks increase essential amino acids and appetite-related responses. Participants include males and females with specific body mass index ranges and regular breakfast habits. Participants will consume various beverages including a carbonated test protein drink, a test protein beverage, a control protein beverage, and a non-carbonated protein beverage. The study uses a randomized, single-blind, crossover design where each participant receives different beverages to compare responses. The beverages are tested to observe their immediate effects on amino acid levels and appetite. During the study, participants will complete visual analog scale questionnaires to rate appetite and undergo blood tests to measure amino acid concentrations up to two hours after beverage consumption. Researchers will monitor hormone responses and satiety feelings, track diet using a smartphone app, and assess safety and adherence throughout. The study aims to measure maximum amino acid levels and appetite responses following beverage intake.

Researchers are evaluating the effects of corn and avocado oils on heart and metabolic health in men and women with mildly to moderately high levels of non-high-density lipoprotein cholesterol (non-HDL-C). The study focuses on how these oils, included as part of controlled feeding diets, influence cardiometabolic risk factors. Participants with hypercholesterolemia aged 18 to 74 years are involved in this randomized, double-blind, controlled feeding crossover trial. Participants will follow two separate 21-day controlled feeding diet periods, each including either corn oil or avocado oil incorporated into yogurt, rolls, and muffins. These two diet periods are separated by a 21-day washout phase where participants return to their usual diet. The study includes seven clinic visits: one screening visit, one baseline visit at the start of the first diet, two visits during each diet period to monitor progress, and a visit at the end of the washout phase marking the start of the second diet period. During the trial, participants will attend clinic visits where blood samples will be taken to measure non-HDL cholesterol changes from baseline to the end of each diet condition. Researchers will also monitor adherence to the diet, health status, and any safety concerns. The total study duration includes the two 21-day diet periods and the washout period, with multiple visits to assess the effects of the oils on cardiometabolic risk factors.

Researchers are evaluating the effects of a dietary supplement containing plant-derived phenolics on body fat composition in generally healthy adults who have risk factors such as high body mass index (BMI), dyslipidemia, or pre-diabetes. The study aims to determine if this supplement can reduce body fat compared to a placebo. This is a randomized, double-blind, placebo-controlled study with three groups. Participants will receive either a dietary supplement containing plant-derived phenolics at two different dose levels or a placebo made of microcrystalline cellulose. The study includes three arms running in parallel, and the treatments are compared over a 24-week period. The supplement and placebo are taken according to the study schedule, but exact dosing details are not specified. During the study, participants will be monitored for changes in body fat mass at 0, 12, and 24 weeks. Researchers will assess body composition and track safety and adherence throughout the study. Participants must follow all study procedures and maintain stable supplement and medication intake during the trial. The study includes multiple visits for assessments and blood draws to evaluate comorbidities and outcomes.

This research aims to evaluate the effects of daily consumption of encapsulated N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT) over four weeks on fat burning in adult women who are overweight or have obesity. The study focuses on whether these plant-derived compounds can increase fat oxidation both at rest and over a 24-hour period, using specialized measurements like indirect calorimetry and stable isotope tracers. It is designed as a pilot study to explore these effects with a controlled, double-blind approach. Participants will be randomly assigned to receive either the active dietary supplement containing plant-derived phenolics or a control supplement with microcrystalline cellulose. They will take the assigned supplement daily for four weeks. The study involves constant monitoring to compare fat oxidation levels between the group taking the active ingredients and the control group by measuring isotope labeling on Day 1 and Day 28 at multiple time points throughout each day. Women participating will undergo assessments including indirect calorimetry and blood tests to measure fat oxidation. They will be asked to use a web-based device to track their diet with an app, maintain their usual diet with some restrictions, and avoid certain supplements. Researchers will monitor their progress closely, including menstrual cycle regularity, medication use, and tobacco history, to ensure safety and adherence. The main outcome is the percentage of a labeled fatty acid oxidized over the study period, measured repeatedly on specified days.

Researchers are evaluating the effects of Dihydroberberine (DHB) supplementation in adults aged 35 to 65 years with pre-diabetes. The study aims to determine if DHB increases the concentration of the hormone GLP-1 in the blood and how it impacts appetite, mood, energy levels, body weight, blood sugar control, and insulin. Participants will be compared to a placebo group to assess any differences caused by DHB. Participants will take either DHB capsules totaling 400 mg daily or placebo capsules containing an inactive substance for six weeks. The capsules are taken orally once a day. The study includes continuous glucose monitoring (CGM) to track blood sugar levels throughout the study period. Participants will also complete self-ratings regarding appetite, mood, and energy. During the study, blood tests will measure changes in GLP-1 levels, blood glucose, insulin, and other markers at baseline and after treatment. Researchers will analyze continuous glucose monitoring data to assess time spent within healthy blood sugar ranges. Participants will be monitored for safety and adherence to study procedures for the six-week duration. The main outcomes focus on changes in GLP-1 peak levels after a single dose and after six weeks of DHB supplementation.

Researchers are evaluating the effects of a 28-day supplementation with Effera human lactoferrin compared to a placebo on gut barrier health in males and females aged 18 to 40 years. The study focuses on gut permeability and gut health, aiming to understand how this dietary supplement may influence these aspects. Samples collected during the study may also be analyzed for lactoferrin absorption and immune biomarkers to provide further insights. Participants will receive either Effera human lactoferrin or a placebo dietary supplement during the 28-day supplementation period. The study is designed as a randomized, double-blind, placebo-controlled, parallel trial. The primary outcome measured is the lactulose to mannitol ratio at the start and after 4 weeks to assess changes in gut permeability. Both groups follow the same schedule and procedures throughout the study. During the study, participants will complete questionnaires about gastrointestinal symptoms and provide various samples for analysis. They will use a smartphone app to record dietary information, and their adherence to study procedures and lifestyle considerations will be monitored. Safety and health assessments, including laboratory tests and clinical evaluations, will be conducted to ensure participant well-being and to measure the study's impact on gut health over the 4-week period.

Researchers are evaluating how nicotinamide adenine dinucleotide (NAD+) and its related metabolites respond to a proprietary nutritional supplement compared to a placebo in generally healthy adults aged 45 to 65 years. The study also looks at markers of health to better understand the supplement's effects. Participants are generally healthy individuals without major medical conditions and within a specific body mass index range. Participants will be randomly assigned to receive either a proprietary nutritional supplement containing 1000 mg of nicotinamide metabolites and plant extracts or a placebo supplement containing 1000 mg of maltodextrin. Both supplements are taken orally once daily for 60 days. The study is designed as a controlled trial to compare these two groups. During the study, participants' blood will be tested to measure NAD+ levels from baseline through day 14, along with other health markers. Researchers will monitor adherence to the daily supplement intake and lifestyle considerations. Participants will also use a personal smartphone with specific operating system requirements to support study procedures. Safety and health status will be assessed throughout the study period.

Researchers are investigating how different cranberry-based fruit juices affect blood sugar, insulin, and GLP-1 levels after eating. The study focuses on adults aged 18 to 45 with certain health criteria and aims to understand how fruit juice consumption influences post-meal metabolic responses. This research is important because fruit juices are commonly consumed for hydration and nutrients, and their liquid form may lead to faster absorption and hormonal changes. Participants will receive various cranberry-based beverages in a randomized, crossover design. These include fruit juices with different sugar levels—zero sugar, two low-sugar formulations, full sugar—and a glucose control beverage. Each participant will consume these beverages during separate visits to compare their effects. During the study, participants will undergo blood glucose measurements over 2 hours after drinking the beverages to assess their metabolic response. They will also be monitored for insulin and GLP-1 changes. The study includes multiple visits with fasting glucose checks and adherence to specific lifestyle guidelines. Safety and health will be evaluated throughout the study period, which includes regular assessments and blood tests.