Laramie

This research aims to evaluate the safety and effectiveness of duvakitug injection in people with moderately to severely active Crohns Disease. It is a multicenter, randomized, double-blind, placebo-controlled Phase 3 study focused on maintaining treatment benefits. The study includes participants aged 16 to 80 years and is sponsored by Sanofi. Participants receive subcutaneous injections of duvakitug or placebo according to the study protocol. The trial includes a 40-week pivotal maintenance sub-study followed by a 240-week open-label extension sub-study for those who continue. The total treatment duration may be up to 280 weeks, with up to 43 on-site visits throughout the study. During the study, participants will have regular assessments including clinical remission, endoscopic response, and other measures related to Crohns Disease activity. Safety is monitored by tracking adverse events and antidrug antibody levels. There is a 45-day follow-up visit after treatment ends. The study duration may be up to 286 weeks depending on participation in the extension phase.

This research aims to compare two approaches for treating previously untreated amblyopia in children aged 3 to under 13 years. It evaluates whether using glasses and patching at the same time leads to similar improvements in vision as first using glasses alone, followed by patching only if needed. The trial focuses on children with amblyopia caused by differences in eye alignment or prescription errors. Children will be assigned randomly to one of two treatment groups one group will wear glasses full-time and add patching for 2 hours daily only if there is no improvement after glasses alone the other group will wear glasses and patch the weaker eye for 2 hours daily at the same time from the start. Vision tests will be done at baseline and follow-up visits every 8 weeks for up to 56 weeks. Participants will have their distance visual acuity measured with trial frames before and after getting their glasses to confirm eligibility. During the study, vision will be monitored to classify improvement or stability, guiding whether patching is needed in the sequential group. Outcomes include changes in vision clarity after 56 weeks and quality-of-life assessments. Regular visits help track progress and safety until study completion.

Researchers are studying alcohol use in college students aged 18 to 25 to see if personalized goal setting combined with protective behavioral strategies PBS can increase the use of these strategies to reduce risk and harm from drinking. The study compares three groups a control group, a group using PBS only, and a group using both PBS and goal setting. This research aims to find out if using PBS more often leads to less alcohol consumption, fewer negative effects, and more positive consequences related to drinking. Participants receive psychoeducation about PBS and either no additional intervention control, PBS-only intervention where they select three protective strategies and a reminder method, or PBS plus goal-setting where they also set two goals for each chosen strategy. The study lasts two weeks, with participants in all groups completing baseline and follow-up assessments. The PBS-only and PBSGoals groups report on their use of reminder strategies, and the PBSGoals group also reports if they achieved their goals. During the study, participants complete questionnaires about their use of protective strategies, alcohol use, and related positive or negative consequences at the start and after two weeks. They also share their confidence and willingness to change their drinking habits and strategy use. Researchers monitor these outcomes to understand the effects of the interventions. The total participation time is two weeks with assessments at baseline and follow-up.

Researchers are studying whether dynamic visual noise DVN, a brief video of rapidly moving black and white squares, can reduce alcohol cravings and consumption in college students who drink and experience cravings at least once a week. The study also explores whether changes in attentional bias toward alcohol help explain how DVN affects cravings and drinking. This is an interventional trial comparing DVN to static visual noise SVN, a still image of black and white squares used as a control. Participants will be randomly assigned to watch either the DVN or SVN daily for seven days, including during a laboratory visit. The DVN consists of a 30-second video of flickering black and white pixel squares that can be restarted as desired. The SVN is a similar static image shown for at least 30 seconds with the option to continue viewing. This design allows comparison of the two visual noise types and their effects on alcohol cravings and consumption. Participants will visit the lab once for baseline data collection, then watch the assigned visual noise daily for seven days. Daily follow-ups will occur for six days after the lab visit, with a final follow-up after one week. Researchers will measure craving strength, craving frequency, alcohol consumption, and attentional bias toward alcohol at baseline and one week later. Immediate changes in craving strength before and after watching the visual noise will also be assessed. The total study duration for participants is about one week.

Researchers are comparing the rates of surgical and minimally invasive interventions, as well as any harms, in Medicare beneficiaries treated with the MILD procedure versus those treated with interspinous process decompression IPD for lumbar spinal stenosis with neurogenic claudication. This observational study uses Medicare claims data to follow patients for 24 months after their initial procedure starting from January 1, 2017. The purpose is to evaluate outcomes between these two types of procedures without requiring prior patient enrollment or consent. The study includes two groups patients who received MILD, which is a percutaneous image-guided lumbar decompression performed under fluoroscopic guidance through a dorsal approach to the spine, and patients who received IPD, a different device-based decompression procedure. Data on reoperations and complications will be collected for both groups over a 24-month follow-up period using Medicare claims. Enrollment continues until the sponsor decides to stop. Participants involvement is passive as the study uses existing Medicare claims data. Researchers will monitor rates of harms related to the initial procedure and subsequent surgical or minimally invasive interventions over two years. No direct patient visits or interventions are conducted, and the study is exempt from institutional review board oversight. The total study duration extends to December 2026, covering cases treated since early 2017.

Researchers are evaluating how to help cancer survivors maintain physical activity after completing a community-based exercise oncology program. The study focuses on developing an adaptive intervention to support long-term exercise habits. It aims to understand if the intervention is feasible and acceptable, and to see how well survivors meet exercise guidelines six months after finishing the initial program. Participants first join a supervised exercise program that includes group aerobic and resistance sessions twice a week, plus three behavior change discussion sessions. After completing this program, they enter a three-month period without active intervention to live freely. Based on their physical activity at three months, participants are grouped as Responders or Incomplete Responders. They are then randomly assigned to different maintenance interventions, including no further intervention, monthly behavior change sessions, or a combination of monthly sessions plus bi-weekly exercise classes. Throughout the study, physical activity is measured at several points baseline, after the exercise program, three months post-program, and six months post-program. Researchers also assess quality of life and physical fitness, including aerobic capacity and muscular strength. The study includes surveys, focus groups, and interviews to gather feedback on intervention feasibility, implementation, and sustainability. Overall participation spans the initial program plus up to six months of follow-up.