Effects of 24-Week Walnut Consumption on Brain Blood Flow and Cognitive Function in Adults with Abdominal Obesity Aged 45 to 75

What this Trial Is About

Researchers are evaluating the long-term effects of walnut consumption on brain function in abdominally obese men and postmenopausal women aged 45 to 75 years. The study focuses on how walnuts may improve brain vascular function and insulin sensitivity, which are important for cognitive health and appetite regulation. This interventional study is designed to assess these effects over 24 weeks with a randomized, controlled parallel design. Participants will be assigned to either consume 50 grams of raw walnuts daily or refrain from nut consumption as a control for 24 weeks. The walnut intake corresponds to about 15% of daily energy. The study will measure cerebral blood flow responses before and after intranasal insulin administration using MRI-perfusion techniques. Secondary assessments include cognitive performance and brain reward activity related to appetite. During the study, participants will visit the research facility at baseline and after 24 weeks for assessments including MRI scans, cognitive tests, and evaluations of brain activity and vascular function. Researchers will track changes in cerebral blood flow and brain insulin sensitivity to compare the walnut and control groups. The study is sponsored by Maastricht University Medical Center and aims to provide insights into dietary influences on brain health in abdominal obesity.

Long-Term Effects of Walnut Consumption on Brain Function