What is enlicitide and rosuvastatin studying in this healthy adult trial?

This trial is studying how the body absorbs and processes enlicitide and rosuvastatin, both when taken separately and combined in one tablet. Researchers want to understand drug levels over time to help improve medication use. The study is sponsored by Merck Sharp & Dohme LLC.

Who may be eligible for this healthy adult clinical trial?

Adults aged 18 to 55 who are medically healthy and non-smokers may be eligible. Female participants who can become pregnant are excluded. Use of medications, herbal remedies, or supplements before the study is also restricted. Please review eligibility criteria for more details.

Is there any cost to participate in this healthy adult clinical trial?

Study-related care, including the study drugs and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Phase 1

Age: 18Years - 55Years

All Genders

Healthy Volunteers

ID07300280

A Clinical Study to Evaluate the Relative Bioavailability of Enlicitide and Rosuvastatin Tablets Compared to Their Separate Use in Healthy Adults

Led by Merck Sharp & Dohme LLC · Updated on 2026-05-28

Participants Needed

Research Sites

1 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating two medicines, enlicitide and rosuvastatin, in healthy adults to understand how much of each drug is present in the body over time. The study compares these medicines when taken separately versus combined into one tablet. This phase 1 trial aims to learn about the relative bioavailability of these drugs to improve medication options. Participants will receive either a single dose of enlicitide and rosuvastatin tablets taken together or a single dose of a combined tablet MK-0616A or its formulation B. The study has two parts, with each part involving these different dosing methods to compare how the body processes the drugs. During the study, blood samples will be collected before dosing and at specific times up to 168 hours after to measure drug levels, including total exposure and maximum concentration. Participants will be monitored for any side effects for up to approximately 9 weeks, with treatment discontinuation tracked if side effects occur. The total participation time varies based on the dosing schedule and follow-up assessments.

CONDITIONS

Brief Title

A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039)

Who Can Participate

Age: 18Years - 55Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Medically healthy with no significant medical history
Non-smoker who has not used nicotine or tobacco products for at least 3 months
Age between 18 and 55 years

You will not qualify if you...

Unable or unwilling to stop using any drugs, including prescription, non-prescription medications, herbal remedies, or vitamin supplements starting 14 days before study entry
Female participant of childbearing potential

Research Team

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