Long-Term Follow-Up and Care for Patients Who Received Donor Stem Cell Transplants Evaluating Treatment Response, Disease Relapse, and Late Effects After Transplant

What this Trial Is About

This research focuses on patients who have undergone donor stem cell transplants and provides long-term follow-up care and evaluation. It aims to monitor patient responses to treatment, disease relapse, and late effects related to the transplant. The study includes patients aged 10 to 80 years who had their first transplant at least three years before entering the study and were treated under NHLBI protocols. Participants are generally seen every 12 months for various procedures, including physical exams, eye exams, blood and urine tests, bone marrow aspiration and biopsy, tissue biopsies, and several imaging tests such as nuclear scans, MRI, CT, and PET scans. Lung and heart function tests are also part of the evaluation. Disease relapse or transplant-related problems may be managed with standard medical, radiation, or surgical therapies, or patients may be offered experimental treatments. During the study, participants undergo periodic assessments to track their health status and transplant outcomes. These include clinical exams, laboratory tests, biopsies, and imaging to detect complications or disease progression. The study does not provide investigational treatments but offers access to experienced NIH hematologists for managing post-transplant complications. Data collected will help researchers understand long-term transplant effects and support future research. Participation involves annual clinic visits and ongoing monitoring.

Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants