Chronic viral coinfections differentially affect the likelihood of developing long COVID.
Michael J Peluso, Tyler-Marie Deveau, Sadie E Munter...
https://pubmed.ncbi.nlm.nih.gov/36454631Actively Recruiting
Age: 18Years - 100Years
All Genders
ID04362150
Long-term Impact of Infection With Novel Coronavirus (LIINC): An Observational Study
Led by University of California, San Francisco · Updated on 2025-06-12
800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying individuals who have recovered from COVID-19 to understand the long-term effects of the infection. This observational study focuses on how the virus affects the immune system and other health factors over time, including differences based on age, gender, and race. The study aims to create a detailed collection of clinical data and biological samples to explore immune responses and health variations among participants. Volunteers who tested positive for COVID-19 and have recovered from the acute phase of the illness participate in this study. Participants attend visits at the hospital starting with a baseline visit, followed by monthly visits for three months, and then every three months for up to two years. Each visit involves interviews, saliva collection, and blood draws. Personal identifiers are removed from the collected specimens to maintain privacy. Participants are involved in detailed interviews and provide biological samples at scheduled visits lasting from 20 to 90 minutes. Researchers collect information about demographics, previous hospitalizations, and monitor long COVID symptoms at multiple time points up to 24 months after infection. The study assesses immune activation, inflammation, and changes in immune function while focusing on participant safety and privacy throughout the process.
CONDITIONS
Brief Title
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
Who Can Participate
Age: 18Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
- Willing and able to provide written informed consent
- Age 18 years or older
- History of SARS-CoV-2 infection confirmed by laboratory positive test or reliable participant report
- At least 21 days have passed since the first positive test or symptom onset, whichever is earlier
You will not qualify if you...
- Chronic anemia with hemoglobin less than 9 g/dL (excluding anemia during acute illness)
- Serious medical or psychiatric illness that interferes with study participation or informed consent
- Active drug or alcohol use or dependence interfering with adherence or consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 2 years
Participants who have recovered from COVID-19 are observed to investigate long-term clinical consequences of infection, including immune function and medical conditions.
1 baseline visit, monthly visits for 3 months, then visits every 3 months
Trial Site Locations
Total: 1 location
1
Zuckerberg San Francisco General Hospital (ZSFG)
San Francisco, California, United States, 94110
Actively Recruiting
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Research Team
R
Rebecca Hoh
M
Michael J Peluso, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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