Actively Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Led by Massive Bio, Inc. · Updated on 2025-10-28
50000
Participants Needed
68
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of an Artificial Intelligence-based tool to help match patients with advanced solid and blood cancers to appropriate clinical trials. This international registry study includes both adult and pediatric patients who have already been considered for clinical trial enrollment by their primary healthcare providers. The study aims to assess the feasibility, clinical usefulness, financial impact, and patient outcomes related to this AI-driven matching approach. The intervention involves a specialized software application that connects with existing electronic health records to extract and analyze individual patient data. This data is compared with a database of available clinical trials using machine learning algorithms to dynamically identify the best matches based on trial availability and patient characteristics. The study is observational and non-interventional, with treatment decisions made by the patient's healthcare team supported by virtual tumor boards and AI reports. Data collection occurs every three months over about 36 months, including 24 months of patient enrollment and 12 months of follow-up. Participants will voluntarily enroll and continue receiving care as usual. Researchers will collect and analyze clinical data, biomarker information, and enrollment barriers to evaluate how many eligible patients actually enroll in trials and the impact on survival outcomes. The primary outcome is the proportion of patients eligible for versus actually enrolling in clinical trials, with secondary outcomes including overall survival, progression-free survival, and virtual tumor board use. The study plans to enroll over 50,000 patients worldwide to gather real-world evidence on this AI-assisted trial matching process.
CONDITIONS
Brief Title
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with solid and hematological malignancies
- Patients with cancer-related biomarkers or gene variants determined by local lab, external vendor, or next generation sequencing
- Decision to consider clinical trial enrollment by primary provider and/or patient
You will not qualify if you...
- Eastern Cooperative Oncology Group Performance Status greater than 2
- Abnormal organ function
- Enrollment in hospice care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - Approximately 36 months
Participants are observed prospectively with clinical data extracted from electronic health records and matched to clinical trials using AI algorithms. No protocol-mandated tests or procedures are required.
Data collection every 3 months
Trial Site Locations
Total: 68 locations
1
Massive Bio SYNERGY-AI site
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Massive Bio SYNERGY-AI site
Mobile, Alabama, United States, 36604
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3
Massive Bio SYNERGY-AI site
Scottsdale, Arizona, United States, 85260
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4
Massive Bio SYNERGY-AI site
Little Rock, Arkansas, United States, 72205
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5
Massive Bio SYNERGY-AI site
Duarte, California, United States, 91010
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6
Massive Bio SYNERGY-AI site
Irvine, California, United States, 92618
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7
Massive Bio SYNERGY-AI site
La Jolla, California, United States, 92093
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8
Massive Bio SYNERGY-AI site
Orange, California, United States, 92868
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9
Massive Bio SYNERGY-AI site
San Francisco, California, United States, 94143
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10
Massive Bio SYNERGY-AI site
Stanford, California, United States, 94305
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11
Massive Bio SYNERGY-AI site
Aurora, Colorado, United States, 80045
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12
Massive Bio SYNERGY-AI site
Denver, Colorado, United States, 80218
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13
Massive Bio SYNERGY-AI site
Littleton, Colorado, United States, 80129
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14
Massive Bio SYNERGY-AI site
Hartford, Connecticut, United States, 06102
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15
Massive Bio SYNERGY-AI site
Norwalk, Connecticut, United States, 06856
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16
Massive Bio SYNERGY-AI site
Newark, Delaware, United States, 19713
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17
Massive Bio SYNERGY-AI site
Jacksonville, Florida, United States, 32224
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18
Massive Bio SYNERGY-AI site
Miami, Florida, United States, 33136
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19
Massive Bio SYNERGY-AI site
Tampa, Florida, United States, 33612
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20
Massive Bio SYNERGY-AI site
Atlanta, Georgia, United States, 30322
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21
Massive Bio SYNERGY-AI site
Savannah, Georgia, United States, 31405
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22
Massive Bio SYNERGY-AI site
Boise, Idaho, United States, 83706
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23
Massive Bio SYNERGY-AI site
Chicago, Illinois, United States, 60611
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24
Massive Bio SYNERGY-AI site
Iowa City, Iowa, United States, 52242
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25
Massive Bio SYNERGY-AI site
New Orleans, Louisiana, United States, 70112
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26
Massive Bio SYNERGY-AI site
Scarborough, Maine, United States, 04074
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27
Massive Bio SYNERGY-AI site
Baltimore, Maryland, United States, 21218
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28
Massive Bio SYNERGY-AI site
Bethesda, Maryland, United States, 20892
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29
Massive Bio SYNERGY-AI site
Silver Spring, Maryland, United States, 20904
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30
Massive Bio SYNERGY-AI site
Towson, Maryland, United States, 21204
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31
Massive Bio SYNERGY-AI site
Worcester, Massachusetts, United States, 01655
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32
Massive Bio SYNERGY-AI site
Ann Arbor, Michigan, United States, 48109
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33
Massive Bio SYNERGY-AI site
Lansing, Michigan, United States, 48912
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34
Massive Bio SYNERGY-AI site
Duluth, Minnesota, United States, 55805
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35
Massive Bio SYNERGY-AI site
Hattiesburg, Mississippi, United States, 39401
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36
Massive Bio SYNERGY-AI site
Kansas City, Missouri, United States, 64111
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37
Massive Bio SYNERGY-AI site
St Louis, Missouri, United States, 63110
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38
Massive Bio SYNERGY-AI site
Billings, Montana, United States, 59102
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39
Massive Bio SYNERGY-AI site
Omaha, Nebraska, United States, 68124
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40
Massive Bio SYNERGY-AI site
New Brunswick, New Jersey, United States, 08901
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41
Massive Bio SYNERGY-AI site
Albuquerque, New Mexico, United States, 87131
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42
Massive Bio SYNERGY-AI site
Buffalo, New York, United States, 14263
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43
Massive Bio SYNERGY-AI site
Hempstead, New York, United States, 11042
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44
Massive Bio SYNERGY-AI site
Manhasset, New York, United States, 11030
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45
Massive Bio SYNERGY-AI site
New York, New York, United States, 10006
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46
Massive Bio SYNERGY-AI site
Staten Island, New York, United States, 10314
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47
Massive Bio SYNERGY-AI site
Chapel Hill, North Carolina, United States, 27514
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48
Massive Bio SYNERGY-AI site
Winston-Salem, North Carolina, United States, 27157
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49
Massive Bio SYNERGY-AI site
Fargo, North Dakota, United States, 58102
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50
Massive Bio SYNERGY-AI site
Cincinnati, Ohio, United States, 45219
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51
Massive Bio SYNERGY-AI site
Columbus, Ohio, United States, 43210
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52
Massive Bio SYNERGY-AI site
Mayfield Heights, Ohio, United States, 44124
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53
Massive Bio SYNERGY-AI site
Tulsa, Oklahoma, United States, 74146
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54
Massive Bio SYNERGY-AI site
Portland, Oregon, United States, 97239
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55
Massive Bio SYNERGY-AI site
Philadelphia, Pennsylvania, United States, 19044
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56
Massive Bio SYNERGY-AI site
Providence, Rhode Island, United States, 02903
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57
Massive Bio SYNERGY-AI site
Greenville, South Carolina, United States, 29605
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58
Massive Bio SYNERGY-AI site
Memphis, Tennessee, United States, 38105
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59
Massive Bio SYNERGY-AI site
Nashville, Tennessee, United States, 37203
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60
Massive Bio SYNERGY-AI site
Dallas, Texas, United States, 75246
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61
Massive Bio SYNERGY-AI site
Houston, Texas, United States, 77030
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62
Massive Bio SYNERGY-AI site
Temple, Texas, United States, 76508
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63
Massive Bio SYNERGY-AI site
Salt Lake City, Utah, United States, 84112
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64
Massive Bio SYNERGY-AI site
Charlottesville, Virginia, United States, 22908
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65
Massive Bio SYNERGY-AI site
Seattle, Washington, United States, 98109
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66
Massive Bio SYNERGY-AI site
Morgantown, West Virginia, United States, 26506
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67
Massive Bio SYNERGY-AI site
Milwaukee, Wisconsin, United States, 53226
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68
Massive Bio SYNERGY-AI site
San Juan, Puerto Rico, 00917
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Research Team
F
Fiona Evans, MS
D
Diego Barrenechea, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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