Application of Intracranial Pressure-Directed Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.
Jun Yang, Junlin Lu, Runting Li...
https://pubmed.ncbi.nlm.nih.gov/35360218/Actively Recruiting
Led by Beijing Tiantan Hospital · Updated on 2023-12-01
5000
Participants Needed
2
Research Sites
4 weeks
Total Duration
Rupture of intracranial aneurysms can cause a serious brain bleeding condition called aneurysmal subarachnoid hemorrhage aSAH, which has a high risk of death and long-term neurological problems. Researchers are studying the long-term outcomes of emergency treatments for this condition to improve diagnosis, treatment effectiveness, and reduce the medical burden and costs. This observational clinical trial is led by Beijing Tiantan Hospital and involves multiple centers using a multidisciplinary approach. The study observes patients who receive either surgical clipping or endovascular coiling, two main emergency treatments for aSAH. Surgical clipping involves placing a clip on the ruptured aneurysm, while endovascular coiling blocks blood flow into the aneurysm to prevent further bleeding. The trial collects detailed information about patients treated with these procedures without altering their care. Participants are followed over two years, with evaluations of neurological outcomes at 10 days, 3 months, 6 months, 12 months, and 24 months after treatment. Researchers also assess cognitive function and monitor for major heart or brain-related events during this time. The study aims to gather long-term data to guide future treatment strategies and improve patient care.
CONDITIONS
Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage
R
Runting Li, MD
X
Xiaolin Chen, MD
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Beijing Tiantan Hospital
Lead Sponsor
Peking University International Hospital
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 days
Participants undergo surgical clipping or endovascular coiling to treat the ruptured aneurysm, followed by immediate post-operative care.
1 visit at 10 days after the procedure
Duration - Up to 24 months
Participants are followed over time to monitor neurological outcomes, cognitive function, and major adverse cardiac or cerebrovascular events.
Visits at 3 months, 6 months, 12 months, and 24 months after the procedure
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/35870093/Beijing Tiantan Hospital
Lead Sponsor
Peking University International Hospital
Collaborating Sponsor