Actively Recruiting
A Longitudinal Study to Identify Mechanisms of Menopause on Cardiovascular Disease Risk
Led by University of Copenhagen · Updated on 2023-05-10
200
Participants Needed
1
Research Sites
1180 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
With the cessation of estrogen production at menopause, the risk of cardiovascular disease like arthrosclerosis, myocardial infarction and stroke increases dramatically. Physical activity is the single most powerful "drug" for maintaining and improving cardiovascular health, but recent data suggest that the positive effect of physical activity is lost at menopause. In this project the investigators will follow a cohort of 200 women from before the women enter menopause and until at least 10 years past menopause. By advanced invasive methodologies the investigators will monitor the changes that occur in the blood vessels of the circulation, the heart and the brain and combine this with microRNA sequencing of blood and tissue samples.
CONDITIONS
Official Title
A Longitudinal Study to Identify Mechanisms of Menopause on Cardiovascular Disease Risk
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal ECG
- Regular menstruation
You will not qualify if you...
- Participation in other clinical projects
- Smokes or has smoked within the last 10 years
- On hormone therapy
- Has chronic diseases not expected for the study groups, including heart problems, atrial fibrillation, cancer, immune diseases, and previous strokes with significant effects
- Being treated with oral steroids
- Has alcohol or drug abuse or is being treated with disulfiram (Antabus)
- Unable to understand informed consent or study procedures
- Pregnancy or breastfeeding
- Systolic blood pressure 64 140 mmHg and/or diastolic blood pressure 64 90 mmHg
- Ovariectomy
- BMI greater than 28
AI-Screening
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Trial Site Locations
Total: 1 location
1
Deparment of Nutrition, Exercise and Sports
Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
L
Lasse Gliemann, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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