Actively Recruiting
Lung Recruitment Assessed by Two-Dimensional and Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Led by Peking Union Medical College Hospital · Updated on 2026-01-30
50
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating lung recruitment potential in patients with acute respiratory failure who are mechanically ventilated. The study aims to compare and assess the consistency between three methods: recruitment-to-inflation ratio (R/I ratio), two-dimensional electrical impedance tomography (2D-EIT), and three-dimensional electrical impedance tomography (3D-EIT). This observational study seeks to determine if these methods provide consistent predictions for lung recruitment potential during ventilator support. Participants will undergo a standardized positive end-expiratory pressure (PEEP) titration procedure while being monitored simultaneously by 2D- and 3D-EIT. The R/I ratio will be measured at both high and low PEEP levels to evaluate lung recruitment. This process is done under sedation and analgesia, without spontaneous breathing, to optimize mechanical ventilation settings. During the study, patients will be closely monitored for lung recruitment using the mentioned diagnostic tests within 24 hours after enrollment. Data collected includes oxygenation levels and lung responses to PEEP adjustments. The study also includes safety monitoring for hemodynamic stability and contraindications to ensure patient well-being throughout the procedure.
CONDITIONS
Brief Title
Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing
- Oxygenation index less than 300 mmHg
- Patients clinically judged by the attending doctor to require PEEP titration
You will not qualify if you...
- Under 18 years of age
- Pregnancy
- Contraindications for EIT examination such as implantable cardioverter defibrillator, implantable pumps, chest wounds, severe thoracic deformity
- No informed consent obtained
- Hemodynamic instability with intolerance to high PEEP levels
- High-risk conditions like pneumothorax or mediastinal emphysema as determined by the attending doctor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 24 hours post-enrollment
Participants undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- Electrical Impedance Tomography (EIT).
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
H
Huaiwu He
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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